An inverse association between serum gamma glutamyl transpeptidase activity and Breslow's lifestyle index; its practical application for screening of subjects with unhealthy lifestyles

Hirokazu Yokoyama, Hideki Ohgo, Hiroshi Hirose, Susumu Moriya, Toshifumi Hibi, Ikuo Saito

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We examined whether serum γGTP activity (γGTP) is associated with Breslow's lifestyle index and whether it could be used as a tool to detect subjects with unhealthy lifestyles. To that effect, 724 male Japanese workers excluding patients suffering from hepatitis virus infection, autoimmune liver diseases and apparently active bile duct diseases were cross-sectionally examined. γGTP was inversely associated with the total score of Breslow's index for all subjects (λ=30.643) and in subjects aged 40 or more (λ=37.073). The association was consistent even after adjustments of subjects' ages and levels of triglycerides, total cholesterol and uric acid (p=0.0001). Among the seven lifestyle factors comprising Breslow's index, improper habits of drinking (p<0.0001), smoking (p=0.0204), exercise (p=0.0189) and body weight control (p<0.0001), were associated with increased γGTP. Even in a survey in which subjects who had proper habits of drinking and body weight control were selectively examined, improper habits of smoking and exercise still tended to be associated with increased γGTP. Receiver operating characteristic curves indicated that γGTP was beneficial for detecting subjects who scored two or less on Breslow's index, at least in subjects aged 40 or more. γGTP was associated with insulin resistance level estimated by the homeostasis model assessment (p<0.0001), which was inversely associated with Breslow's index (p=0.0040). γGTP could be used as an objective substitute of Breslow's index, allowing us to identify subjects with low scores on Breslow's index, at least after sorting subjects properly. Such screening would enable interventions to correct subjects' unhealthy lifestyles, helping to solve lifestyle-related disease issues.

Original languageEnglish
Pages (from-to)198-206
Number of pages9
JournalJournal of Occupational Health
Volume48
Issue number3
DOIs
Publication statusPublished - 2006 May

Fingerprint

gamma-Glutamyltransferase
Guanosine Triphosphate
Life Style
Screening
Serum
Weight control
Habits
Drinking
Bile Duct Diseases
Smoking
Body Weight
Exercise
Social Adjustment
Hepatitis Viruses
Virus Diseases
Uric Acid
Viruses
Sorting
ROC Curve
Liver

Keywords

  • γGTP
  • Breslow's index
  • Ethanol
  • Insulin resistance
  • Lifestyle-related diseases

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Toxicology

Cite this

@article{857513ba6413406688f68fdfff460ec5,
title = "An inverse association between serum gamma glutamyl transpeptidase activity and Breslow's lifestyle index; its practical application for screening of subjects with unhealthy lifestyles",
abstract = "We examined whether serum γGTP activity (γGTP) is associated with Breslow's lifestyle index and whether it could be used as a tool to detect subjects with unhealthy lifestyles. To that effect, 724 male Japanese workers excluding patients suffering from hepatitis virus infection, autoimmune liver diseases and apparently active bile duct diseases were cross-sectionally examined. γGTP was inversely associated with the total score of Breslow's index for all subjects (λ=30.643) and in subjects aged 40 or more (λ=37.073). The association was consistent even after adjustments of subjects' ages and levels of triglycerides, total cholesterol and uric acid (p=0.0001). Among the seven lifestyle factors comprising Breslow's index, improper habits of drinking (p<0.0001), smoking (p=0.0204), exercise (p=0.0189) and body weight control (p<0.0001), were associated with increased γGTP. Even in a survey in which subjects who had proper habits of drinking and body weight control were selectively examined, improper habits of smoking and exercise still tended to be associated with increased γGTP. Receiver operating characteristic curves indicated that γGTP was beneficial for detecting subjects who scored two or less on Breslow's index, at least in subjects aged 40 or more. γGTP was associated with insulin resistance level estimated by the homeostasis model assessment (p<0.0001), which was inversely associated with Breslow's index (p=0.0040). γGTP could be used as an objective substitute of Breslow's index, allowing us to identify subjects with low scores on Breslow's index, at least after sorting subjects properly. Such screening would enable interventions to correct subjects' unhealthy lifestyles, helping to solve lifestyle-related disease issues.",
keywords = "γGTP, Breslow's index, Ethanol, Insulin resistance, Lifestyle-related diseases",
author = "Hirokazu Yokoyama and Hideki Ohgo and Hiroshi Hirose and Susumu Moriya and Toshifumi Hibi and Ikuo Saito",
year = "2006",
month = "5",
doi = "10.1539/joh.48.198",
language = "English",
volume = "48",
pages = "198--206",
journal = "Journal of Occupational Health",
issn = "1341-9145",
publisher = "Japan Society for Occupational Health",
number = "3",

}

TY - JOUR

T1 - An inverse association between serum gamma glutamyl transpeptidase activity and Breslow's lifestyle index; its practical application for screening of subjects with unhealthy lifestyles

AU - Yokoyama, Hirokazu

AU - Ohgo, Hideki

AU - Hirose, Hiroshi

AU - Moriya, Susumu

AU - Hibi, Toshifumi

AU - Saito, Ikuo

PY - 2006/5

Y1 - 2006/5

N2 - We examined whether serum γGTP activity (γGTP) is associated with Breslow's lifestyle index and whether it could be used as a tool to detect subjects with unhealthy lifestyles. To that effect, 724 male Japanese workers excluding patients suffering from hepatitis virus infection, autoimmune liver diseases and apparently active bile duct diseases were cross-sectionally examined. γGTP was inversely associated with the total score of Breslow's index for all subjects (λ=30.643) and in subjects aged 40 or more (λ=37.073). The association was consistent even after adjustments of subjects' ages and levels of triglycerides, total cholesterol and uric acid (p=0.0001). Among the seven lifestyle factors comprising Breslow's index, improper habits of drinking (p<0.0001), smoking (p=0.0204), exercise (p=0.0189) and body weight control (p<0.0001), were associated with increased γGTP. Even in a survey in which subjects who had proper habits of drinking and body weight control were selectively examined, improper habits of smoking and exercise still tended to be associated with increased γGTP. Receiver operating characteristic curves indicated that γGTP was beneficial for detecting subjects who scored two or less on Breslow's index, at least in subjects aged 40 or more. γGTP was associated with insulin resistance level estimated by the homeostasis model assessment (p<0.0001), which was inversely associated with Breslow's index (p=0.0040). γGTP could be used as an objective substitute of Breslow's index, allowing us to identify subjects with low scores on Breslow's index, at least after sorting subjects properly. Such screening would enable interventions to correct subjects' unhealthy lifestyles, helping to solve lifestyle-related disease issues.

AB - We examined whether serum γGTP activity (γGTP) is associated with Breslow's lifestyle index and whether it could be used as a tool to detect subjects with unhealthy lifestyles. To that effect, 724 male Japanese workers excluding patients suffering from hepatitis virus infection, autoimmune liver diseases and apparently active bile duct diseases were cross-sectionally examined. γGTP was inversely associated with the total score of Breslow's index for all subjects (λ=30.643) and in subjects aged 40 or more (λ=37.073). The association was consistent even after adjustments of subjects' ages and levels of triglycerides, total cholesterol and uric acid (p=0.0001). Among the seven lifestyle factors comprising Breslow's index, improper habits of drinking (p<0.0001), smoking (p=0.0204), exercise (p=0.0189) and body weight control (p<0.0001), were associated with increased γGTP. Even in a survey in which subjects who had proper habits of drinking and body weight control were selectively examined, improper habits of smoking and exercise still tended to be associated with increased γGTP. Receiver operating characteristic curves indicated that γGTP was beneficial for detecting subjects who scored two or less on Breslow's index, at least in subjects aged 40 or more. γGTP was associated with insulin resistance level estimated by the homeostasis model assessment (p<0.0001), which was inversely associated with Breslow's index (p=0.0040). γGTP could be used as an objective substitute of Breslow's index, allowing us to identify subjects with low scores on Breslow's index, at least after sorting subjects properly. Such screening would enable interventions to correct subjects' unhealthy lifestyles, helping to solve lifestyle-related disease issues.

KW - γGTP

KW - Breslow's index

KW - Ethanol

KW - Insulin resistance

KW - Lifestyle-related diseases

UR - http://www.scopus.com/inward/record.url?scp=33750529770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750529770&partnerID=8YFLogxK

U2 - 10.1539/joh.48.198

DO - 10.1539/joh.48.198

M3 - Article

C2 - 16788281

AN - SCOPUS:33750529770

VL - 48

SP - 198

EP - 206

JO - Journal of Occupational Health

JF - Journal of Occupational Health

SN - 1341-9145

IS - 3

ER -