Analysis for the subcellular distribution of oligonucleotide/lipid complexes.

Toshinori Sato, H. Nishi, Y. Okahata, Y. Shoji, J. Shimada

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Abstract

We synthesized a lipoglutamide having tetraethylene glycol tails (PEG lipid), and prepared a DNA/PEG lipid complex. Observation by a confocal laser scanning fluorescence microscope showed that the oligonucleotide/PEG lipid complex distributed in cytoplasmic region. On the other hand, a oligonucleotide/lipofectin complex distributed in nucleus. Interactions of the oligonucleotide complexes with isolated nucleus were also investigated, and mechanisms of the subcellular distributions were discussed.

Original languageEnglish
Pages (from-to)303-304
Number of pages2
JournalNucleic acids symposium series
Issue number37
Publication statusPublished - 1997
Externally publishedYes

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Sato, T., Nishi, H., Okahata, Y., Shoji, Y., & Shimada, J. (1997). Analysis for the subcellular distribution of oligonucleotide/lipid complexes. Nucleic acids symposium series, (37), 303-304.