Analysis for the subcellular distribution of oligonucleotide/lipid complexes.

Toshinori Sato, H. Nishi, Y. Okahata, Y. Shoji, J. Shimada

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We synthesized a lipoglutamide having tetraethylene glycol tails (PEG lipid), and prepared a DNA/PEG lipid complex. Observation by a confocal laser scanning fluorescence microscope showed that the oligonucleotide/PEG lipid complex distributed in cytoplasmic region. On the other hand, a oligonucleotide/lipofectin complex distributed in nucleus. Interactions of the oligonucleotide complexes with isolated nucleus were also investigated, and mechanisms of the subcellular distributions were discussed.

Original languageEnglish
Pages (from-to)303-304
Number of pages2
JournalNucleic acids symposium series
Issue number37
Publication statusPublished - 1997
Externally publishedYes

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Oligonucleotides
Lipids
Glycols
Lasers
Fluorescence
Observation
DNA
1,2-dielaidoylphosphatidylethanolamine

Cite this

Sato, T., Nishi, H., Okahata, Y., Shoji, Y., & Shimada, J. (1997). Analysis for the subcellular distribution of oligonucleotide/lipid complexes. Nucleic acids symposium series, (37), 303-304.

Analysis for the subcellular distribution of oligonucleotide/lipid complexes. / Sato, Toshinori; Nishi, H.; Okahata, Y.; Shoji, Y.; Shimada, J.

In: Nucleic acids symposium series, No. 37, 1997, p. 303-304.

Research output: Contribution to journalArticle

Sato, T, Nishi, H, Okahata, Y, Shoji, Y & Shimada, J 1997, 'Analysis for the subcellular distribution of oligonucleotide/lipid complexes.', Nucleic acids symposium series, no. 37, pp. 303-304.
Sato, Toshinori ; Nishi, H. ; Okahata, Y. ; Shoji, Y. ; Shimada, J. / Analysis for the subcellular distribution of oligonucleotide/lipid complexes. In: Nucleic acids symposium series. 1997 ; No. 37. pp. 303-304.
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