Analysis for the subcellular distribution of oligonucleotide/lipid complexes.

T. Sato, H. Nishi, Y. Okahata, Y. Shoji, J. Shimada

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We synthesized a lipoglutamide having tetraethylene glycol tails (PEG lipid), and prepared a DNA/PEG lipid complex. Observation by a confocal laser scanning fluorescence microscope showed that the oligonucleotide/PEG lipid complex distributed in cytoplasmic region. On the other hand, a oligonucleotide/lipofectin complex distributed in nucleus. Interactions of the oligonucleotide complexes with isolated nucleus were also investigated, and mechanisms of the subcellular distributions were discussed.

Original languageEnglish
Pages (from-to)303-304
Number of pages2
JournalNucleic acids symposium series
Issue number37
Publication statusPublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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