Analysis of clinical features of community-acquired pneumonia caused by pediatric respiratory syncytial virus and human metapneumovirus

Takafumi Okada, Keita Matsubara, Takahiro Matsushima, Osamu Komiyama, Nahoko Chiba, Keiko Hamano, Miyuki Morozumi, Kimiko Ubukata, Keisuke Sunakawa, Satoshi Iwata

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We retrospectively reviewed the background, clinical features, blood tests, and complications in the 720 children seen for acute respiratory tract infection from July 2004 to December 2005. Of these, 75 (10.5%) were diagnosed with pneumonia due to respiratory syncytial virus (RSV) and 19 (2.6%) with pneumonia due to human metapneumovirus (hMPV) based on multiplex PCR analysis of nasopharyngeal samples. RSV was PCR-positive mostly in winter, -from November to January-, and hMPV mostly in spring, -from March to June. The mean RSV pneumonia group age was 1.3 +/- 1.4 years and in the hMPV pneumonia group 3.0 +/- 3.1 years, showing a statistically significant differences in the age of virus onset. Clinically the RSV group showed more rhinorrhea and wheezing (p < 0.05) and the hMPV group a higher maximum body temperature and a longer wheezing duration (p < 0.05). Fever, cough, vomiting, diarrhea, fever frequency, and C-reactive protein level were similar in both groups (p > 0.05). Complication prevalence was 49.3% in the RSV group and 42.1% in the hMPV group. Acute otitis media was seen more often in the RSV group (32.0%) and febrile convulsion more often in the hMPV group (15.8%) (p > 0.05). These findings may be helpful in clinically diagnosing community-acquired pneumonia due to RSV or hMPV.

Original languageEnglish
Pages (from-to)42-47
Number of pages6
JournalKansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases
Volume84
Issue number1
Publication statusPublished - 2010 Jan
Externally publishedYes

Fingerprint

Metapneumovirus
Respiratory Syncytial Viruses
Pneumonia
Pediatrics
Febrile Seizures
Multiplex Polymerase Chain Reaction
Respiratory Sounds
Otitis Media
Hematologic Tests
Age of Onset
Respiratory Tract Infections
Age Groups
Viruses
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Analysis of clinical features of community-acquired pneumonia caused by pediatric respiratory syncytial virus and human metapneumovirus. / Okada, Takafumi; Matsubara, Keita; Matsushima, Takahiro; Komiyama, Osamu; Chiba, Nahoko; Hamano, Keiko; Morozumi, Miyuki; Ubukata, Kimiko; Sunakawa, Keisuke; Iwata, Satoshi.

In: Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases, Vol. 84, No. 1, 01.2010, p. 42-47.

Research output: Contribution to journalArticle

Okada, Takafumi ; Matsubara, Keita ; Matsushima, Takahiro ; Komiyama, Osamu ; Chiba, Nahoko ; Hamano, Keiko ; Morozumi, Miyuki ; Ubukata, Kimiko ; Sunakawa, Keisuke ; Iwata, Satoshi. / Analysis of clinical features of community-acquired pneumonia caused by pediatric respiratory syncytial virus and human metapneumovirus. In: Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases. 2010 ; Vol. 84, No. 1. pp. 42-47.
@article{66bfd1bd3d4e46728a69a9ed4478adcb,
title = "Analysis of clinical features of community-acquired pneumonia caused by pediatric respiratory syncytial virus and human metapneumovirus",
abstract = "We retrospectively reviewed the background, clinical features, blood tests, and complications in the 720 children seen for acute respiratory tract infection from July 2004 to December 2005. Of these, 75 (10.5{\%}) were diagnosed with pneumonia due to respiratory syncytial virus (RSV) and 19 (2.6{\%}) with pneumonia due to human metapneumovirus (hMPV) based on multiplex PCR analysis of nasopharyngeal samples. RSV was PCR-positive mostly in winter, -from November to January-, and hMPV mostly in spring, -from March to June. The mean RSV pneumonia group age was 1.3 +/- 1.4 years and in the hMPV pneumonia group 3.0 +/- 3.1 years, showing a statistically significant differences in the age of virus onset. Clinically the RSV group showed more rhinorrhea and wheezing (p < 0.05) and the hMPV group a higher maximum body temperature and a longer wheezing duration (p < 0.05). Fever, cough, vomiting, diarrhea, fever frequency, and C-reactive protein level were similar in both groups (p > 0.05). Complication prevalence was 49.3{\%} in the RSV group and 42.1{\%} in the hMPV group. Acute otitis media was seen more often in the RSV group (32.0{\%}) and febrile convulsion more often in the hMPV group (15.8{\%}) (p > 0.05). These findings may be helpful in clinically diagnosing community-acquired pneumonia due to RSV or hMPV.",
author = "Takafumi Okada and Keita Matsubara and Takahiro Matsushima and Osamu Komiyama and Nahoko Chiba and Keiko Hamano and Miyuki Morozumi and Kimiko Ubukata and Keisuke Sunakawa and Satoshi Iwata",
year = "2010",
month = "1",
language = "English",
volume = "84",
pages = "42--47",
journal = "Nippon Densenbyo Gakkai zasshi",
issn = "0387-5911",
publisher = "Nihon Kansensho Gakkai",
number = "1",

}

TY - JOUR

T1 - Analysis of clinical features of community-acquired pneumonia caused by pediatric respiratory syncytial virus and human metapneumovirus

AU - Okada, Takafumi

AU - Matsubara, Keita

AU - Matsushima, Takahiro

AU - Komiyama, Osamu

AU - Chiba, Nahoko

AU - Hamano, Keiko

AU - Morozumi, Miyuki

AU - Ubukata, Kimiko

AU - Sunakawa, Keisuke

AU - Iwata, Satoshi

PY - 2010/1

Y1 - 2010/1

N2 - We retrospectively reviewed the background, clinical features, blood tests, and complications in the 720 children seen for acute respiratory tract infection from July 2004 to December 2005. Of these, 75 (10.5%) were diagnosed with pneumonia due to respiratory syncytial virus (RSV) and 19 (2.6%) with pneumonia due to human metapneumovirus (hMPV) based on multiplex PCR analysis of nasopharyngeal samples. RSV was PCR-positive mostly in winter, -from November to January-, and hMPV mostly in spring, -from March to June. The mean RSV pneumonia group age was 1.3 +/- 1.4 years and in the hMPV pneumonia group 3.0 +/- 3.1 years, showing a statistically significant differences in the age of virus onset. Clinically the RSV group showed more rhinorrhea and wheezing (p < 0.05) and the hMPV group a higher maximum body temperature and a longer wheezing duration (p < 0.05). Fever, cough, vomiting, diarrhea, fever frequency, and C-reactive protein level were similar in both groups (p > 0.05). Complication prevalence was 49.3% in the RSV group and 42.1% in the hMPV group. Acute otitis media was seen more often in the RSV group (32.0%) and febrile convulsion more often in the hMPV group (15.8%) (p > 0.05). These findings may be helpful in clinically diagnosing community-acquired pneumonia due to RSV or hMPV.

AB - We retrospectively reviewed the background, clinical features, blood tests, and complications in the 720 children seen for acute respiratory tract infection from July 2004 to December 2005. Of these, 75 (10.5%) were diagnosed with pneumonia due to respiratory syncytial virus (RSV) and 19 (2.6%) with pneumonia due to human metapneumovirus (hMPV) based on multiplex PCR analysis of nasopharyngeal samples. RSV was PCR-positive mostly in winter, -from November to January-, and hMPV mostly in spring, -from March to June. The mean RSV pneumonia group age was 1.3 +/- 1.4 years and in the hMPV pneumonia group 3.0 +/- 3.1 years, showing a statistically significant differences in the age of virus onset. Clinically the RSV group showed more rhinorrhea and wheezing (p < 0.05) and the hMPV group a higher maximum body temperature and a longer wheezing duration (p < 0.05). Fever, cough, vomiting, diarrhea, fever frequency, and C-reactive protein level were similar in both groups (p > 0.05). Complication prevalence was 49.3% in the RSV group and 42.1% in the hMPV group. Acute otitis media was seen more often in the RSV group (32.0%) and febrile convulsion more often in the hMPV group (15.8%) (p > 0.05). These findings may be helpful in clinically diagnosing community-acquired pneumonia due to RSV or hMPV.

UR - http://www.scopus.com/inward/record.url?scp=77949902689&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949902689&partnerID=8YFLogxK

M3 - Article

VL - 84

SP - 42

EP - 47

JO - Nippon Densenbyo Gakkai zasshi

JF - Nippon Densenbyo Gakkai zasshi

SN - 0387-5911

IS - 1

ER -