Analysis of clinicopathologic factors predicting para-aortic lymph node metastasis in endometrial cancer

Hiroyuki Nomura, Daisuke Aoki, N. Suzuki, N. Susumu, A. Suzuki, Y. Tamada, Fumio Kataoka, A. Higashiguchi, S. Ezawa, S. Nozawa

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The purposes of this study were to compare the relationships between para-aortic lymph node metastasis and various clinicopathologic factors to evaluate whether para-aortic lymph node dissection is necessary when treating endometrial cancer. A retrospective study was performed on 841 patients with endometrial cancer, who underwent the initial surgery at the Keio University Hospital. Clinicopathologic factors related to para-aortic lymph node metastasis significant on a univariate analysis were analyzed in a multivariate fashion using a logistic model. According to the multivariate analysis, the clinicopathologic factor most strongly related to the existence of para-aortic lymph node metastasis was positive pelvic lymph node metastasis (P < 0.01). Among the 155 patients who underwent pelvic and para-aortic lymph node dissection, the difference of 5-year overall survival by the presence of retroperitoneal lymph node metastasis was examined by Kaplan-Meier method. The prognosis was poor even if para-aortic lymph node dissection was performed in cases of positive para-aortic lymph node metastasis. In conclusion, when deciding whether to perform para-aortic lymph node dissection in patients with endometrial cancer, it is necessary to consider the pelvic lymph nodal status. If there is no pelvic lymph node metastasis, it could not be necessary to perform para-aortic lymph node dissection.

Original languageEnglish
Pages (from-to)799-804
Number of pages6
JournalInternational Journal of Gynecological Cancer
Volume16
Issue number2
DOIs
Publication statusPublished - 2006 Mar

Fingerprint

Endometrial Neoplasms
Statistical Factor Analysis
Lymph Nodes
Lymph Node Excision
Neoplasm Metastasis
Lymph
Multivariate Analysis
Retrospective Studies
Logistic Models
Survival

Keywords

  • Endometrial cancer
  • Para-aortic lymph node dissection
  • Para-aortic lymph node metastasis
  • Pelvic lymph node metastasis

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology
  • Cancer Research

Cite this

Analysis of clinicopathologic factors predicting para-aortic lymph node metastasis in endometrial cancer. / Nomura, Hiroyuki; Aoki, Daisuke; Suzuki, N.; Susumu, N.; Suzuki, A.; Tamada, Y.; Kataoka, Fumio; Higashiguchi, A.; Ezawa, S.; Nozawa, S.

In: International Journal of Gynecological Cancer, Vol. 16, No. 2, 03.2006, p. 799-804.

Research output: Contribution to journalArticle

Nomura, Hiroyuki ; Aoki, Daisuke ; Suzuki, N. ; Susumu, N. ; Suzuki, A. ; Tamada, Y. ; Kataoka, Fumio ; Higashiguchi, A. ; Ezawa, S. ; Nozawa, S. / Analysis of clinicopathologic factors predicting para-aortic lymph node metastasis in endometrial cancer. In: International Journal of Gynecological Cancer. 2006 ; Vol. 16, No. 2. pp. 799-804.
@article{d8b88b0184bb47c485039c89ebdfea85,
title = "Analysis of clinicopathologic factors predicting para-aortic lymph node metastasis in endometrial cancer",
abstract = "The purposes of this study were to compare the relationships between para-aortic lymph node metastasis and various clinicopathologic factors to evaluate whether para-aortic lymph node dissection is necessary when treating endometrial cancer. A retrospective study was performed on 841 patients with endometrial cancer, who underwent the initial surgery at the Keio University Hospital. Clinicopathologic factors related to para-aortic lymph node metastasis significant on a univariate analysis were analyzed in a multivariate fashion using a logistic model. According to the multivariate analysis, the clinicopathologic factor most strongly related to the existence of para-aortic lymph node metastasis was positive pelvic lymph node metastasis (P < 0.01). Among the 155 patients who underwent pelvic and para-aortic lymph node dissection, the difference of 5-year overall survival by the presence of retroperitoneal lymph node metastasis was examined by Kaplan-Meier method. The prognosis was poor even if para-aortic lymph node dissection was performed in cases of positive para-aortic lymph node metastasis. In conclusion, when deciding whether to perform para-aortic lymph node dissection in patients with endometrial cancer, it is necessary to consider the pelvic lymph nodal status. If there is no pelvic lymph node metastasis, it could not be necessary to perform para-aortic lymph node dissection.",
keywords = "Endometrial cancer, Para-aortic lymph node dissection, Para-aortic lymph node metastasis, Pelvic lymph node metastasis",
author = "Hiroyuki Nomura and Daisuke Aoki and N. Suzuki and N. Susumu and A. Suzuki and Y. Tamada and Fumio Kataoka and A. Higashiguchi and S. Ezawa and S. Nozawa",
year = "2006",
month = "3",
doi = "10.1111/j.1525-1438.2006.00529.x",
language = "English",
volume = "16",
pages = "799--804",
journal = "International Journal of Gynecological Cancer",
issn = "1048-891X",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Analysis of clinicopathologic factors predicting para-aortic lymph node metastasis in endometrial cancer

AU - Nomura, Hiroyuki

AU - Aoki, Daisuke

AU - Suzuki, N.

AU - Susumu, N.

AU - Suzuki, A.

AU - Tamada, Y.

AU - Kataoka, Fumio

AU - Higashiguchi, A.

AU - Ezawa, S.

AU - Nozawa, S.

PY - 2006/3

Y1 - 2006/3

N2 - The purposes of this study were to compare the relationships between para-aortic lymph node metastasis and various clinicopathologic factors to evaluate whether para-aortic lymph node dissection is necessary when treating endometrial cancer. A retrospective study was performed on 841 patients with endometrial cancer, who underwent the initial surgery at the Keio University Hospital. Clinicopathologic factors related to para-aortic lymph node metastasis significant on a univariate analysis were analyzed in a multivariate fashion using a logistic model. According to the multivariate analysis, the clinicopathologic factor most strongly related to the existence of para-aortic lymph node metastasis was positive pelvic lymph node metastasis (P < 0.01). Among the 155 patients who underwent pelvic and para-aortic lymph node dissection, the difference of 5-year overall survival by the presence of retroperitoneal lymph node metastasis was examined by Kaplan-Meier method. The prognosis was poor even if para-aortic lymph node dissection was performed in cases of positive para-aortic lymph node metastasis. In conclusion, when deciding whether to perform para-aortic lymph node dissection in patients with endometrial cancer, it is necessary to consider the pelvic lymph nodal status. If there is no pelvic lymph node metastasis, it could not be necessary to perform para-aortic lymph node dissection.

AB - The purposes of this study were to compare the relationships between para-aortic lymph node metastasis and various clinicopathologic factors to evaluate whether para-aortic lymph node dissection is necessary when treating endometrial cancer. A retrospective study was performed on 841 patients with endometrial cancer, who underwent the initial surgery at the Keio University Hospital. Clinicopathologic factors related to para-aortic lymph node metastasis significant on a univariate analysis were analyzed in a multivariate fashion using a logistic model. According to the multivariate analysis, the clinicopathologic factor most strongly related to the existence of para-aortic lymph node metastasis was positive pelvic lymph node metastasis (P < 0.01). Among the 155 patients who underwent pelvic and para-aortic lymph node dissection, the difference of 5-year overall survival by the presence of retroperitoneal lymph node metastasis was examined by Kaplan-Meier method. The prognosis was poor even if para-aortic lymph node dissection was performed in cases of positive para-aortic lymph node metastasis. In conclusion, when deciding whether to perform para-aortic lymph node dissection in patients with endometrial cancer, it is necessary to consider the pelvic lymph nodal status. If there is no pelvic lymph node metastasis, it could not be necessary to perform para-aortic lymph node dissection.

KW - Endometrial cancer

KW - Para-aortic lymph node dissection

KW - Para-aortic lymph node metastasis

KW - Pelvic lymph node metastasis

UR - http://www.scopus.com/inward/record.url?scp=33646051252&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646051252&partnerID=8YFLogxK

U2 - 10.1111/j.1525-1438.2006.00529.x

DO - 10.1111/j.1525-1438.2006.00529.x

M3 - Article

VL - 16

SP - 799

EP - 804

JO - International Journal of Gynecological Cancer

JF - International Journal of Gynecological Cancer

SN - 1048-891X

IS - 2

ER -