Analysis of comorbid factors that increase the COPD assessment test scores

Masaki Miyazaki, Hidetoshi Nakamura, Shotaro Chubachi, Mamoru Sasaki, Mizuha Haraguchi, Shuichi Yoshida, Keishi Tsuduki, Toru Shirahata, Saeko Takahashi, Naoto Minematsu, Hidefumi Koh, Morio Nakamura, Fumio Sakamaki, Takeshi Terashima, Koichi Sayama, Paul W. Jones, Koichiro Asano, Tomoko Betsuyaku, Takashi Inoue, Naoki Miyao & 5 others Kazumi Nishio, Hiroki Tateno, Yoshitaka Oyamada, Tatsu Matsuzaki, Akira Umeda

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Background: The chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) is a concise health status measure for COPD. COPD patients have a variety of comorbidities, but little is known about their impact on quality of life. This study was designed to investigate comorbid factors that may contribute to high CAT scores.Methods: An observational study at Keio University and affiliated hospitals enrolled 336 COPD patients and 67 non-COPD subjects. Health status was assessed by the CAT, the St. Georges Respiratory Questionnaire (SGRQ), and all components of the Medical Outcomes Study Short-Form 36-Item (SF-36) version 2, which is a generic measure of health. Comorbidities were identified based on patients' reports, physicians' records, and questionnaires, including the Frequency Scale for the Symptoms of Gastro-esophageal reflux disease (GERD) and the Hospital Anxiety and Depression Scale. Dual X-ray absorptiometry measurements of bone mineral density were performed.Results: The CAT showed moderate-good correlations with the SGRQ and all components of the SF-36. The presence of GERD, depression, arrhythmia, and anxiety was significantly associated with a high CAT score in the COPD patients.Conclusions: Symptomatic COPD patients have a high prevalence of comorbidities. A high CAT score should alert the clinician to a higher likelihood of certain comorbidities such as GERD and depression, because these diseases may co-exist unrecognized. Trial registration: Clinical trial registered with UMIN (UMIN000003470).

Original languageEnglish
Article number13
JournalRespiratory Research
Volume15
Issue number1
DOIs
Publication statusPublished - 2014 Feb 6

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Chronic Obstructive Pulmonary Disease
Statistical Factor Analysis
Esophageal Diseases
Comorbidity
Gastroesophageal Reflux
Depression
Health Status
Anxiety
Obstructive Lung Diseases
Photon Absorptiometry
Bone Density
Observational Studies
Cardiac Arrhythmias
Quality of Life
Outcome Assessment (Health Care)
Clinical Trials
Physicians
Health

Keywords

  • Chronic obstructive pulmonary disease
  • Comorbidity
  • Depression
  • Gastro-esophageal reflux
  • Health status
  • Osteoporosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Miyazaki, M., Nakamura, H., Chubachi, S., Sasaki, M., Haraguchi, M., Yoshida, S., ... Umeda, A. (2014). Analysis of comorbid factors that increase the COPD assessment test scores. Respiratory Research, 15(1), [13]. https://doi.org/10.1186/1465-9921-15-13

Analysis of comorbid factors that increase the COPD assessment test scores. / Miyazaki, Masaki; Nakamura, Hidetoshi; Chubachi, Shotaro; Sasaki, Mamoru; Haraguchi, Mizuha; Yoshida, Shuichi; Tsuduki, Keishi; Shirahata, Toru; Takahashi, Saeko; Minematsu, Naoto; Koh, Hidefumi; Nakamura, Morio; Sakamaki, Fumio; Terashima, Takeshi; Sayama, Koichi; Jones, Paul W.; Asano, Koichiro; Betsuyaku, Tomoko; Inoue, Takashi; Miyao, Naoki; Nishio, Kazumi; Tateno, Hiroki; Oyamada, Yoshitaka; Matsuzaki, Tatsu; Umeda, Akira.

In: Respiratory Research, Vol. 15, No. 1, 13, 06.02.2014.

Research output: Contribution to journalArticle

Miyazaki, M, Nakamura, H, Chubachi, S, Sasaki, M, Haraguchi, M, Yoshida, S, Tsuduki, K, Shirahata, T, Takahashi, S, Minematsu, N, Koh, H, Nakamura, M, Sakamaki, F, Terashima, T, Sayama, K, Jones, PW, Asano, K, Betsuyaku, T, Inoue, T, Miyao, N, Nishio, K, Tateno, H, Oyamada, Y, Matsuzaki, T & Umeda, A 2014, 'Analysis of comorbid factors that increase the COPD assessment test scores', Respiratory Research, vol. 15, no. 1, 13. https://doi.org/10.1186/1465-9921-15-13
Miyazaki, Masaki ; Nakamura, Hidetoshi ; Chubachi, Shotaro ; Sasaki, Mamoru ; Haraguchi, Mizuha ; Yoshida, Shuichi ; Tsuduki, Keishi ; Shirahata, Toru ; Takahashi, Saeko ; Minematsu, Naoto ; Koh, Hidefumi ; Nakamura, Morio ; Sakamaki, Fumio ; Terashima, Takeshi ; Sayama, Koichi ; Jones, Paul W. ; Asano, Koichiro ; Betsuyaku, Tomoko ; Inoue, Takashi ; Miyao, Naoki ; Nishio, Kazumi ; Tateno, Hiroki ; Oyamada, Yoshitaka ; Matsuzaki, Tatsu ; Umeda, Akira. / Analysis of comorbid factors that increase the COPD assessment test scores. In: Respiratory Research. 2014 ; Vol. 15, No. 1.
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AU - Miyazaki, Masaki

AU - Nakamura, Hidetoshi

AU - Chubachi, Shotaro

AU - Sasaki, Mamoru

AU - Haraguchi, Mizuha

AU - Yoshida, Shuichi

AU - Tsuduki, Keishi

AU - Shirahata, Toru

AU - Takahashi, Saeko

AU - Minematsu, Naoto

AU - Koh, Hidefumi

AU - Nakamura, Morio

AU - Sakamaki, Fumio

AU - Terashima, Takeshi

AU - Sayama, Koichi

AU - Jones, Paul W.

AU - Asano, Koichiro

AU - Betsuyaku, Tomoko

AU - Inoue, Takashi

AU - Miyao, Naoki

AU - Nishio, Kazumi

AU - Tateno, Hiroki

AU - Oyamada, Yoshitaka

AU - Matsuzaki, Tatsu

AU - Umeda, Akira

PY - 2014/2/6

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N2 - Background: The chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) is a concise health status measure for COPD. COPD patients have a variety of comorbidities, but little is known about their impact on quality of life. This study was designed to investigate comorbid factors that may contribute to high CAT scores.Methods: An observational study at Keio University and affiliated hospitals enrolled 336 COPD patients and 67 non-COPD subjects. Health status was assessed by the CAT, the St. Georges Respiratory Questionnaire (SGRQ), and all components of the Medical Outcomes Study Short-Form 36-Item (SF-36) version 2, which is a generic measure of health. Comorbidities were identified based on patients' reports, physicians' records, and questionnaires, including the Frequency Scale for the Symptoms of Gastro-esophageal reflux disease (GERD) and the Hospital Anxiety and Depression Scale. Dual X-ray absorptiometry measurements of bone mineral density were performed.Results: The CAT showed moderate-good correlations with the SGRQ and all components of the SF-36. The presence of GERD, depression, arrhythmia, and anxiety was significantly associated with a high CAT score in the COPD patients.Conclusions: Symptomatic COPD patients have a high prevalence of comorbidities. A high CAT score should alert the clinician to a higher likelihood of certain comorbidities such as GERD and depression, because these diseases may co-exist unrecognized. Trial registration: Clinical trial registered with UMIN (UMIN000003470).

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KW - Chronic obstructive pulmonary disease

KW - Comorbidity

KW - Depression

KW - Gastro-esophageal reflux

KW - Health status

KW - Osteoporosis

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