Analysis of diagnosing lung cancer in patients with idiopathic interstitial pneumonia by CT and 18F-FDG-PET/CT

Issei Yamada, Kumiya Sugiyama, Izumi Kishiro, Kanae Shiobara, Taichi Shiobara, Mineaki Watanabe, Fumiya Fukushima, Hirokuni Hirata, Hiroaki Arakawa, Masafumi Arima, Yasutsugu Fukushima, Koji Murakami, Takeshi Fukuda

Research output: Contribution to journal › Article

Abstract

Objective: Idiopathic interstitial pneumonia (IIP) is often complicated by lung cancer. Lung cancer may be often indistinguishable from inflammation on computed tomography (CT). Design: We examined the comparison of usefulness between CT and 18F-fluorodeoxyglucose positron emission tomography/CT (18F-FDG-PET/CT) in those lesions. Materials and Methods: Subjects were 75 patients with IIP who were suspected of having lung cancer and underwent 18FFDG- PET/CT over a 5-year period. Fifty-four patients were diagnosed with lung cancer, including 5 patients with synchronous double lung cancer, and 21 with other disease. The relationship between the interpretation of CT and 18F-FDG-PET/CT by certified radiological specialists and final diagnosis was analyzed. Results: For the interpretation of CT, sensitivity was 81.4% and specificity 76.2%, while that for 18F-FDG-PET/CT was 88.1% and 90.5%, respectively. Of 59 lung cancer lesions, 52 (88.1%) were interpreted as "definitive lung cancer" and 58 (98.3%) as "suspected or definitive lung cancer" on either CT or 18F-FDG-PET/CT. One lesion was missed by both modalities. Conclusion: In diagnosing lung cancer associated with IIP, high sensitivities were shown in both 18F-FDG-PET/CT and CT. However, some lesions were erroneously diagnosed on CT. When lung cancer was suspected clinically, 18F-FDG- PET/CT should be considered, because 18F-FDG-PET/CT is non-invasive and shows high specificity.

Original languageEnglish
Pages (from-to)167-171
Number of pages5
JournalInternational Medical Journal
Volume20
Issue number2
Publication statusPublished - 2013 Apr
Externally publishedYes

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Idiopathic Interstitial Pneumonias
Fluorodeoxyglucose F18
Lung Neoplasms
Tomography

Keywords

  • F-fluorodeoxyglucose positron emission tomography
  • Computed tomography
  • Idiopathic interstitial pneumonia
  • Idiopathicpulmonary fibrosis
  • Lung cancer

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Yamada, I., Sugiyama, K., Kishiro, I., Shiobara, K., Shiobara, T., Watanabe, M., ... Fukuda, T. (2013). Analysis of diagnosing lung cancer in patients with idiopathic interstitial pneumonia by CT and 18F-FDG-PET/CT. International Medical Journal, 20(2), 167-171.

Analysis of diagnosing lung cancer in patients with idiopathic interstitial pneumonia by CT and 18F-FDG-PET/CT. / Yamada, Issei; Sugiyama, Kumiya; Kishiro, Izumi; Shiobara, Kanae; Shiobara, Taichi; Watanabe, Mineaki; Fukushima, Fumiya; Hirata, Hirokuni; Arakawa, Hiroaki; Arima, Masafumi; Fukushima, Yasutsugu; Murakami, Koji; Fukuda, Takeshi.

In: International Medical Journal, Vol. 20, No. 2, 04.2013, p. 167-171.

Research output: Contribution to journal › Article

Yamada, I, Sugiyama, K, Kishiro, I, Shiobara, K, Shiobara, T, Watanabe, M, Fukushima, F, Hirata, H, Arakawa, H, Arima, M, Fukushima, Y, Murakami, K & Fukuda, T 2013, 'Analysis of diagnosing lung cancer in patients with idiopathic interstitial pneumonia by CT and 18F-FDG-PET/CT', International Medical Journal, vol. 20, no. 2, pp. 167-171.
Yamada I, Sugiyama K, Kishiro I, Shiobara K, Shiobara T, Watanabe M et al. Analysis of diagnosing lung cancer in patients with idiopathic interstitial pneumonia by CT and 18F-FDG-PET/CT. International Medical Journal. 2013 Apr;20(2):167-171.
Yamada, Issei ; Sugiyama, Kumiya ; Kishiro, Izumi ; Shiobara, Kanae ; Shiobara, Taichi ; Watanabe, Mineaki ; Fukushima, Fumiya ; Hirata, Hirokuni ; Arakawa, Hiroaki ; Arima, Masafumi ; Fukushima, Yasutsugu ; Murakami, Koji ; Fukuda, Takeshi. / Analysis of diagnosing lung cancer in patients with idiopathic interstitial pneumonia by CT and 18F-FDG-PET/CT. In: International Medical Journal. 2013 ; Vol. 20, No. 2. pp. 167-171.
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abstract = "Objective: Idiopathic interstitial pneumonia (IIP) is often complicated by lung cancer. Lung cancer may be often indistinguishable from inflammation on computed tomography (CT). Design: We examined the comparison of usefulness between CT and 18F-fluorodeoxyglucose positron emission tomography/CT (18F-FDG-PET/CT) in those lesions. Materials and Methods: Subjects were 75 patients with IIP who were suspected of having lung cancer and underwent 18FFDG- PET/CT over a 5-year period. Fifty-four patients were diagnosed with lung cancer, including 5 patients with synchronous double lung cancer, and 21 with other disease. The relationship between the interpretation of CT and 18F-FDG-PET/CT by certified radiological specialists and final diagnosis was analyzed. Results: For the interpretation of CT, sensitivity was 81.4{\%} and specificity 76.2{\%}, while that for 18F-FDG-PET/CT was 88.1{\%} and 90.5{\%}, respectively. Of 59 lung cancer lesions, 52 (88.1{\%}) were interpreted as {"}definitive lung cancer{"} and 58 (98.3{\%}) as {"}suspected or definitive lung cancer{"} on either CT or 18F-FDG-PET/CT. One lesion was missed by both modalities. Conclusion: In diagnosing lung cancer associated with IIP, high sensitivities were shown in both 18F-FDG-PET/CT and CT. However, some lesions were erroneously diagnosed on CT. When lung cancer was suspected clinically, 18F-FDG- PET/CT should be considered, because 18F-FDG-PET/CT is non-invasive and shows high specificity.",
keywords = "F-fluorodeoxyglucose positron emission tomography, Computed tomography, Idiopathic interstitial pneumonia, Idiopathicpulmonary fibrosis, Lung cancer",
author = "Issei Yamada and Kumiya Sugiyama and Izumi Kishiro and Kanae Shiobara and Taichi Shiobara and Mineaki Watanabe and Fumiya Fukushima and Hirokuni Hirata and Hiroaki Arakawa and Masafumi Arima and Yasutsugu Fukushima and Koji Murakami and Takeshi Fukuda",
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T1 - Analysis of diagnosing lung cancer in patients with idiopathic interstitial pneumonia by CT and 18F-FDG-PET/CT

AU - Yamada, Issei

AU - Sugiyama, Kumiya

AU - Kishiro, Izumi

AU - Shiobara, Kanae

AU - Shiobara, Taichi

AU - Watanabe, Mineaki

AU - Fukushima, Fumiya

AU - Hirata, Hirokuni

AU - Arakawa, Hiroaki

AU - Arima, Masafumi

AU - Fukushima, Yasutsugu

AU - Murakami, Koji

AU - Fukuda, Takeshi

PY - 2013/4

Y1 - 2013/4

N2 - Objective: Idiopathic interstitial pneumonia (IIP) is often complicated by lung cancer. Lung cancer may be often indistinguishable from inflammation on computed tomography (CT). Design: We examined the comparison of usefulness between CT and 18F-fluorodeoxyglucose positron emission tomography/CT (18F-FDG-PET/CT) in those lesions. Materials and Methods: Subjects were 75 patients with IIP who were suspected of having lung cancer and underwent 18FFDG- PET/CT over a 5-year period. Fifty-four patients were diagnosed with lung cancer, including 5 patients with synchronous double lung cancer, and 21 with other disease. The relationship between the interpretation of CT and 18F-FDG-PET/CT by certified radiological specialists and final diagnosis was analyzed. Results: For the interpretation of CT, sensitivity was 81.4% and specificity 76.2%, while that for 18F-FDG-PET/CT was 88.1% and 90.5%, respectively. Of 59 lung cancer lesions, 52 (88.1%) were interpreted as "definitive lung cancer" and 58 (98.3%) as "suspected or definitive lung cancer" on either CT or 18F-FDG-PET/CT. One lesion was missed by both modalities. Conclusion: In diagnosing lung cancer associated with IIP, high sensitivities were shown in both 18F-FDG-PET/CT and CT. However, some lesions were erroneously diagnosed on CT. When lung cancer was suspected clinically, 18F-FDG- PET/CT should be considered, because 18F-FDG-PET/CT is non-invasive and shows high specificity.

AB - Objective: Idiopathic interstitial pneumonia (IIP) is often complicated by lung cancer. Lung cancer may be often indistinguishable from inflammation on computed tomography (CT). Design: We examined the comparison of usefulness between CT and 18F-fluorodeoxyglucose positron emission tomography/CT (18F-FDG-PET/CT) in those lesions. Materials and Methods: Subjects were 75 patients with IIP who were suspected of having lung cancer and underwent 18FFDG- PET/CT over a 5-year period. Fifty-four patients were diagnosed with lung cancer, including 5 patients with synchronous double lung cancer, and 21 with other disease. The relationship between the interpretation of CT and 18F-FDG-PET/CT by certified radiological specialists and final diagnosis was analyzed. Results: For the interpretation of CT, sensitivity was 81.4% and specificity 76.2%, while that for 18F-FDG-PET/CT was 88.1% and 90.5%, respectively. Of 59 lung cancer lesions, 52 (88.1%) were interpreted as "definitive lung cancer" and 58 (98.3%) as "suspected or definitive lung cancer" on either CT or 18F-FDG-PET/CT. One lesion was missed by both modalities. Conclusion: In diagnosing lung cancer associated with IIP, high sensitivities were shown in both 18F-FDG-PET/CT and CT. However, some lesions were erroneously diagnosed on CT. When lung cancer was suspected clinically, 18F-FDG- PET/CT should be considered, because 18F-FDG-PET/CT is non-invasive and shows high specificity.

KW - F-fluorodeoxyglucose positron emission tomography

KW - Computed tomography

KW - Idiopathic interstitial pneumonia

KW - Idiopathicpulmonary fibrosis

KW - Lung cancer

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M3 - Article

VL - 20

SP - 167

EP - 171

JO - International Medical Journal

JF - International Medical Journal

SN - 1341-2051

IS - 2

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