TY - GEN
T1 - Analysis of elasticity and deformability of erythrocytes using micro-channel flow system and atomic force microscope
AU - Minamitani, Haruyuki
AU - Tsukada, Kosuke
AU - Kawamura, Tomoni
AU - Sekizuka, Eiichi
AU - Oshio, Chikara
N1 - Publisher Copyright:
© 2000 IEEE.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2000
Y1 - 2000
N2 - Mechanical properties of erythrocytes under diabetic and some other physico-chemical conditions were measured by using transparent micro-channel flow system for the analysis of erythrocyte deformability and also by using atomic force microscope (AFM) for the analysis of microscopic elasticity of the erythrocyte cell membrane respectively. Deformability of diabetic erythrocytes was significantly lower than that of healthy controls, especially at higher shear rate. The spring constant and the Young's modulus of diabetic erythrocytes were much higher than those of healthy controls. These erythrocytes were obviously stiffened to be hard to deform themselves in the capillary flow passage that may follow to the growth of microangiopathy.
AB - Mechanical properties of erythrocytes under diabetic and some other physico-chemical conditions were measured by using transparent micro-channel flow system for the analysis of erythrocyte deformability and also by using atomic force microscope (AFM) for the analysis of microscopic elasticity of the erythrocyte cell membrane respectively. Deformability of diabetic erythrocytes was significantly lower than that of healthy controls, especially at higher shear rate. The spring constant and the Young's modulus of diabetic erythrocytes were much higher than those of healthy controls. These erythrocytes were obviously stiffened to be hard to deform themselves in the capillary flow passage that may follow to the growth of microangiopathy.
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U2 - 10.1109/MMB.2000.893743
DO - 10.1109/MMB.2000.893743
M3 - Conference contribution
AN - SCOPUS:84952651240
T3 - 1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings
SP - 68
EP - 71
BT - 1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings
A2 - Dittmar, Andre
A2 - Beebe, David
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, MMB 2000
Y2 - 12 October 2000 through 14 October 2000
ER -
