Analysis of elasticity and deformability of erythrocytes using micro-channel flow system and atomic force microscope

Haruyuki Minamitani, Kosuke Tsukada, Tomoni Kawamura, Eiichi Sekizuka, Chikara Oshio

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Mechanical properties of erythrocytes under diabetic and some other physico-chemical conditions were measured by using transparent micro-channel flow system for the analysis of erythrocyte deformability and also by using atomic force microscope (AFM) for the analysis of microscopic elasticity of the erythrocyte cell membrane respectively. Deformability of diabetic erythrocytes was significantly lower than that of healthy controls, especially at higher shear rate. The spring constant and the Young's modulus of diabetic erythrocytes were much higher than those of healthy controls. These erythrocytes were obviously stiffened to be hard to deform themselves in the capillary flow passage that may follow to the growth of microangiopathy.

Original languageEnglish
Title of host publication1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages68-71
Number of pages4
ISBN (Print)0780366034, 9780780366039
DOIs
Publication statusPublished - 2000
Event1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, MMB 2000 - Lyon, France
Duration: 2000 Oct 122000 Oct 14

Other

Other1st Annual International IEEE-EMBS Special Topic Conference on Microtechnologies in Medicine and Biology, MMB 2000
CountryFrance
CityLyon
Period00/10/1200/10/14

ASJC Scopus subject areas

  • Engineering(all)

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