Abstract
There are a lot of skeletal disorders, and the pathogenesis underlying those diseases is varied. However, mechanisms underlying some disorders, particularly osteoporosis and rheumatoid arthritis, were, at least in part, clarified and therapeutic targets for those diseases were identified. Hypoxia inducible factor 1 alpha was identified to be required for osteoclast activation in postmenopausal osteoporosis, while signal transducer and activator of transcription 3 was demonstrated to contribute for development of chronic arthritis and joint destruction in rheumatoid arthritis.
| Original language | English |
|---|---|
| Pages (from-to) | 1182-1187 |
| Number of pages | 6 |
| Journal | Clinical calcium |
| Volume | 25 |
| Issue number | 8 |
| Publication status | Published - 2015 Aug 1 |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Analysis of Musculoskeletal Systems and Their Diseases. Pathology and therapy for skeletal disorder. / Miyamoto, Takeshi.
In: Clinical calcium, Vol. 25, No. 8, 01.08.2015, p. 1182-1187.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Analysis of Musculoskeletal Systems and Their Diseases. Pathology and therapy for skeletal disorder
AU - Miyamoto, Takeshi
PY - 2015/8/1
Y1 - 2015/8/1
N2 - There are a lot of skeletal disorders, and the pathogenesis underlying those diseases is varied. However, mechanisms underlying some disorders, particularly osteoporosis and rheumatoid arthritis, were, at least in part, clarified and therapeutic targets for those diseases were identified. Hypoxia inducible factor 1 alpha was identified to be required for osteoclast activation in postmenopausal osteoporosis, while signal transducer and activator of transcription 3 was demonstrated to contribute for development of chronic arthritis and joint destruction in rheumatoid arthritis.
AB - There are a lot of skeletal disorders, and the pathogenesis underlying those diseases is varied. However, mechanisms underlying some disorders, particularly osteoporosis and rheumatoid arthritis, were, at least in part, clarified and therapeutic targets for those diseases were identified. Hypoxia inducible factor 1 alpha was identified to be required for osteoclast activation in postmenopausal osteoporosis, while signal transducer and activator of transcription 3 was demonstrated to contribute for development of chronic arthritis and joint destruction in rheumatoid arthritis.
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UR - http://www.scopus.com/inward/citedby.url?scp=84952716767&partnerID=8YFLogxK
M3 - Article
C2 - 26224676
AN - SCOPUS:84952716767
VL - 25
SP - 1182
EP - 1187
JO - Clinical calcium
JF - Clinical calcium
SN - 0917-5857
IS - 8
ER -