Analysis of Musculoskeletal Systems and Their Diseases. Pathology and therapy for skeletal disorder

Takeshi Miyamoto

Research output: Contribution to journalArticle

Abstract

There are a lot of skeletal disorders, and the pathogenesis underlying those diseases is varied. However, mechanisms underlying some disorders, particularly osteoporosis and rheumatoid arthritis, were, at least in part, clarified and therapeutic targets for those diseases were identified. Hypoxia inducible factor 1 alpha was identified to be required for osteoclast activation in postmenopausal osteoporosis, while signal transducer and activator of transcription 3 was demonstrated to contribute for development of chronic arthritis and joint destruction in rheumatoid arthritis.

Original languageEnglish
Pages (from-to)1182-1187
Number of pages6
JournalClinical calcium
Volume25
Issue number8
Publication statusPublished - 2015 Aug 1

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Musculoskeletal System
Systems Analysis
Rheumatoid Arthritis
Pathology
Hypoxia-Inducible Factor 1
STAT3 Transcription Factor
Postmenopausal Osteoporosis
Osteoclasts
Osteoporosis
Arthritis
Joints
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Analysis of Musculoskeletal Systems and Their Diseases. Pathology and therapy for skeletal disorder. / Miyamoto, Takeshi.

In: Clinical calcium, Vol. 25, No. 8, 01.08.2015, p. 1182-1187.

Research output: Contribution to journalArticle

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