Abstract
Thoracic diseases in patients with systemic lupus erythematosus (SLE), especially interstitial pneumonia (SLE-IP), are rare and have been poorly studied. The aims of this multicentre study were to evaluate SLE-IP and elucidate its clinical characteristics and prognosis. Fifty-five patients with SLE-IP who had attended the respiratory departments of participating hospitals were retrospectively evaluated in this multicentre study. Clinical information, high-resolution computed tomography (HRCT), and surgical lung biopsy/autopsy specimens were analysed by respiratory physicians, pulmonary radiologists, and pulmonary pathologists. IP patterns on HRCT and lung specimens were classified based on the international classification statement/guideline for idiopathic interstitial pneumonias. The most frequent form of SLE-IP at diagnosis was chronic IP (63.6%), followed by subacute (20.0%), and acute IP (12.7%). Radiologically, the most common HRCT pattern was “Unclassifiable” (54%). Histologically, “Unclassifiable” was the most frequently found (41.7%) among 12 patients with histologically proven IP. Interestingly, accompanying airway diseases were present in nine of these patients (75%). In multivariate analysis, current smoking (hazard ratio [HR] 6.105, p = 0.027), thrombocytopenia (HR 7.676, p = 0.010), anti-double-strand DNA titre (HR 0.956, p = 0.027), and nonspecific interstitial pneumonia (NSIP) + organizing pneumonia (OP) pattern on HRCT (vs. NSIP, HR 0.089, p = 0.023) were significant prognostic factors. In conclusion, chronic IP was the most frequent form of IP in patients with SLE-IP, and “Unclassifiable” was the commonest pattern radiologically and histologically.
| Original language | English |
|---|---|
| Article number | 7355 |
| Journal | Scientific reports |
| Volume | 9 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2019 Dec 1 |
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Cite this
Analysis of systemic lupus erythematosus-related interstitial pneumonia : a retrospective multicentre study. / Enomoto, Noriyuki; Egashira, Ryoko; Tabata, Kazuhiro; Hashisako, Mikiko; Kitani, Masashi; Waseda, Yuko; Ishizuka, Tamotsu; Watanabe, Satoshi; Kasahara, Kazuo; Izumi, Shinyu; Shiraki, Akira; Miyamoto, Atsushi; Kishi, Kazuma; Kishaba, Tomoo; Sugimoto, Chikatosi; Inoue, Yoshikazu; Kataoka, Kensuke; Kondoh, Yasuhiro; Tsuchiya, Yutaka; Baba, Tomohisa; Sugiura, Hiroaki; Tanaka, Tomonori; Sumikawa, Hiromitsu; Suda, Takafumi.
In: Scientific reports, Vol. 9, No. 1, 7355, 01.12.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Analysis of systemic lupus erythematosus-related interstitial pneumonia
T2 - a retrospective multicentre study
AU - Enomoto, Noriyuki
AU - Egashira, Ryoko
AU - Tabata, Kazuhiro
AU - Hashisako, Mikiko
AU - Kitani, Masashi
AU - Waseda, Yuko
AU - Ishizuka, Tamotsu
AU - Watanabe, Satoshi
AU - Kasahara, Kazuo
AU - Izumi, Shinyu
AU - Shiraki, Akira
AU - Miyamoto, Atsushi
AU - Kishi, Kazuma
AU - Kishaba, Tomoo
AU - Sugimoto, Chikatosi
AU - Inoue, Yoshikazu
AU - Kataoka, Kensuke
AU - Kondoh, Yasuhiro
AU - Tsuchiya, Yutaka
AU - Baba, Tomohisa
AU - Sugiura, Hiroaki
AU - Tanaka, Tomonori
AU - Sumikawa, Hiromitsu
AU - Suda, Takafumi
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Thoracic diseases in patients with systemic lupus erythematosus (SLE), especially interstitial pneumonia (SLE-IP), are rare and have been poorly studied. The aims of this multicentre study were to evaluate SLE-IP and elucidate its clinical characteristics and prognosis. Fifty-five patients with SLE-IP who had attended the respiratory departments of participating hospitals were retrospectively evaluated in this multicentre study. Clinical information, high-resolution computed tomography (HRCT), and surgical lung biopsy/autopsy specimens were analysed by respiratory physicians, pulmonary radiologists, and pulmonary pathologists. IP patterns on HRCT and lung specimens were classified based on the international classification statement/guideline for idiopathic interstitial pneumonias. The most frequent form of SLE-IP at diagnosis was chronic IP (63.6%), followed by subacute (20.0%), and acute IP (12.7%). Radiologically, the most common HRCT pattern was “Unclassifiable” (54%). Histologically, “Unclassifiable” was the most frequently found (41.7%) among 12 patients with histologically proven IP. Interestingly, accompanying airway diseases were present in nine of these patients (75%). In multivariate analysis, current smoking (hazard ratio [HR] 6.105, p = 0.027), thrombocytopenia (HR 7.676, p = 0.010), anti-double-strand DNA titre (HR 0.956, p = 0.027), and nonspecific interstitial pneumonia (NSIP) + organizing pneumonia (OP) pattern on HRCT (vs. NSIP, HR 0.089, p = 0.023) were significant prognostic factors. In conclusion, chronic IP was the most frequent form of IP in patients with SLE-IP, and “Unclassifiable” was the commonest pattern radiologically and histologically.
AB - Thoracic diseases in patients with systemic lupus erythematosus (SLE), especially interstitial pneumonia (SLE-IP), are rare and have been poorly studied. The aims of this multicentre study were to evaluate SLE-IP and elucidate its clinical characteristics and prognosis. Fifty-five patients with SLE-IP who had attended the respiratory departments of participating hospitals were retrospectively evaluated in this multicentre study. Clinical information, high-resolution computed tomography (HRCT), and surgical lung biopsy/autopsy specimens were analysed by respiratory physicians, pulmonary radiologists, and pulmonary pathologists. IP patterns on HRCT and lung specimens were classified based on the international classification statement/guideline for idiopathic interstitial pneumonias. The most frequent form of SLE-IP at diagnosis was chronic IP (63.6%), followed by subacute (20.0%), and acute IP (12.7%). Radiologically, the most common HRCT pattern was “Unclassifiable” (54%). Histologically, “Unclassifiable” was the most frequently found (41.7%) among 12 patients with histologically proven IP. Interestingly, accompanying airway diseases were present in nine of these patients (75%). In multivariate analysis, current smoking (hazard ratio [HR] 6.105, p = 0.027), thrombocytopenia (HR 7.676, p = 0.010), anti-double-strand DNA titre (HR 0.956, p = 0.027), and nonspecific interstitial pneumonia (NSIP) + organizing pneumonia (OP) pattern on HRCT (vs. NSIP, HR 0.089, p = 0.023) were significant prognostic factors. In conclusion, chronic IP was the most frequent form of IP in patients with SLE-IP, and “Unclassifiable” was the commonest pattern radiologically and histologically.
UR - http://www.scopus.com/inward/record.url?scp=85065644557&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065644557&partnerID=8YFLogxK
U2 - 10.1038/s41598-019-43782-7
DO - 10.1038/s41598-019-43782-7
M3 - Article
AN - SCOPUS:85065644557
VL - 9
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 7355
ER -