Analysis of systemic lupus erythematosus-related interstitial pneumonia

a retrospective multicentre study

Noriyuki Enomoto, Ryoko Egashira, Kazuhiro Tabata, Mikiko Hashisako, Masashi Kitani, Yuko Waseda, Tamotsu Ishizuka, Satoshi Watanabe, Kazuo Kasahara, Shinyu Izumi, Akira Shiraki, Atsushi Miyamoto, Kazuma Kishi, Tomoo Kishaba, Chikatosi Sugimoto, Yoshikazu Inoue, Kensuke Kataoka, Yasuhiro Kondoh, Yutaka Tsuchiya, Tomohisa Baba & 4 others Hiroaki Sugiura, Tomonori Tanaka, Hiromitsu Sumikawa, Takafumi Suda

Research output: Contribution to journalArticle

Abstract

Thoracic diseases in patients with systemic lupus erythematosus (SLE), especially interstitial pneumonia (SLE-IP), are rare and have been poorly studied. The aims of this multicentre study were to evaluate SLE-IP and elucidate its clinical characteristics and prognosis. Fifty-five patients with SLE-IP who had attended the respiratory departments of participating hospitals were retrospectively evaluated in this multicentre study. Clinical information, high-resolution computed tomography (HRCT), and surgical lung biopsy/autopsy specimens were analysed by respiratory physicians, pulmonary radiologists, and pulmonary pathologists. IP patterns on HRCT and lung specimens were classified based on the international classification statement/guideline for idiopathic interstitial pneumonias. The most frequent form of SLE-IP at diagnosis was chronic IP (63.6%), followed by subacute (20.0%), and acute IP (12.7%). Radiologically, the most common HRCT pattern was “Unclassifiable” (54%). Histologically, “Unclassifiable” was the most frequently found (41.7%) among 12 patients with histologically proven IP. Interestingly, accompanying airway diseases were present in nine of these patients (75%). In multivariate analysis, current smoking (hazard ratio [HR] 6.105, p = 0.027), thrombocytopenia (HR 7.676, p = 0.010), anti-double-strand DNA titre (HR 0.956, p = 0.027), and nonspecific interstitial pneumonia (NSIP) + organizing pneumonia (OP) pattern on HRCT (vs. NSIP, HR 0.089, p = 0.023) were significant prognostic factors. In conclusion, chronic IP was the most frequent form of IP in patients with SLE-IP, and “Unclassifiable” was the commonest pattern radiologically and histologically.

Original languageEnglish
Article number7355
JournalScientific reports
Volume9
Issue number1
DOIs
Publication statusPublished - 2019 Dec 1

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Interstitial Lung Diseases
Systemic Lupus Erythematosus
Multicenter Studies
Retrospective Studies
Tomography
Lung
Idiopathic Interstitial Pneumonias
Thoracic Diseases
Hospital Departments
Thrombocytopenia
Autopsy
Pneumonia
Multivariate Analysis
Smoking
Guidelines
Physicians
Biopsy
DNA

ASJC Scopus subject areas

  • General

Cite this

Enomoto, N., Egashira, R., Tabata, K., Hashisako, M., Kitani, M., Waseda, Y., ... Suda, T. (2019). Analysis of systemic lupus erythematosus-related interstitial pneumonia: a retrospective multicentre study. Scientific reports, 9(1), [7355]. https://doi.org/10.1038/s41598-019-43782-7

Analysis of systemic lupus erythematosus-related interstitial pneumonia : a retrospective multicentre study. / Enomoto, Noriyuki; Egashira, Ryoko; Tabata, Kazuhiro; Hashisako, Mikiko; Kitani, Masashi; Waseda, Yuko; Ishizuka, Tamotsu; Watanabe, Satoshi; Kasahara, Kazuo; Izumi, Shinyu; Shiraki, Akira; Miyamoto, Atsushi; Kishi, Kazuma; Kishaba, Tomoo; Sugimoto, Chikatosi; Inoue, Yoshikazu; Kataoka, Kensuke; Kondoh, Yasuhiro; Tsuchiya, Yutaka; Baba, Tomohisa; Sugiura, Hiroaki; Tanaka, Tomonori; Sumikawa, Hiromitsu; Suda, Takafumi.

In: Scientific reports, Vol. 9, No. 1, 7355, 01.12.2019.

Research output: Contribution to journalArticle

Enomoto, N, Egashira, R, Tabata, K, Hashisako, M, Kitani, M, Waseda, Y, Ishizuka, T, Watanabe, S, Kasahara, K, Izumi, S, Shiraki, A, Miyamoto, A, Kishi, K, Kishaba, T, Sugimoto, C, Inoue, Y, Kataoka, K, Kondoh, Y, Tsuchiya, Y, Baba, T, Sugiura, H, Tanaka, T, Sumikawa, H & Suda, T 2019, 'Analysis of systemic lupus erythematosus-related interstitial pneumonia: a retrospective multicentre study', Scientific reports, vol. 9, no. 1, 7355. https://doi.org/10.1038/s41598-019-43782-7
Enomoto, Noriyuki ; Egashira, Ryoko ; Tabata, Kazuhiro ; Hashisako, Mikiko ; Kitani, Masashi ; Waseda, Yuko ; Ishizuka, Tamotsu ; Watanabe, Satoshi ; Kasahara, Kazuo ; Izumi, Shinyu ; Shiraki, Akira ; Miyamoto, Atsushi ; Kishi, Kazuma ; Kishaba, Tomoo ; Sugimoto, Chikatosi ; Inoue, Yoshikazu ; Kataoka, Kensuke ; Kondoh, Yasuhiro ; Tsuchiya, Yutaka ; Baba, Tomohisa ; Sugiura, Hiroaki ; Tanaka, Tomonori ; Sumikawa, Hiromitsu ; Suda, Takafumi. / Analysis of systemic lupus erythematosus-related interstitial pneumonia : a retrospective multicentre study. In: Scientific reports. 2019 ; Vol. 9, No. 1.
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abstract = "Thoracic diseases in patients with systemic lupus erythematosus (SLE), especially interstitial pneumonia (SLE-IP), are rare and have been poorly studied. The aims of this multicentre study were to evaluate SLE-IP and elucidate its clinical characteristics and prognosis. Fifty-five patients with SLE-IP who had attended the respiratory departments of participating hospitals were retrospectively evaluated in this multicentre study. Clinical information, high-resolution computed tomography (HRCT), and surgical lung biopsy/autopsy specimens were analysed by respiratory physicians, pulmonary radiologists, and pulmonary pathologists. IP patterns on HRCT and lung specimens were classified based on the international classification statement/guideline for idiopathic interstitial pneumonias. The most frequent form of SLE-IP at diagnosis was chronic IP (63.6{\%}), followed by subacute (20.0{\%}), and acute IP (12.7{\%}). Radiologically, the most common HRCT pattern was “Unclassifiable” (54{\%}). Histologically, “Unclassifiable” was the most frequently found (41.7{\%}) among 12 patients with histologically proven IP. Interestingly, accompanying airway diseases were present in nine of these patients (75{\%}). In multivariate analysis, current smoking (hazard ratio [HR] 6.105, p = 0.027), thrombocytopenia (HR 7.676, p = 0.010), anti-double-strand DNA titre (HR 0.956, p = 0.027), and nonspecific interstitial pneumonia (NSIP) + organizing pneumonia (OP) pattern on HRCT (vs. NSIP, HR 0.089, p = 0.023) were significant prognostic factors. In conclusion, chronic IP was the most frequent form of IP in patients with SLE-IP, and “Unclassifiable” was the commonest pattern radiologically and histologically.",
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AU - Enomoto, Noriyuki

AU - Egashira, Ryoko

AU - Tabata, Kazuhiro

AU - Hashisako, Mikiko

AU - Kitani, Masashi

AU - Waseda, Yuko

AU - Ishizuka, Tamotsu

AU - Watanabe, Satoshi

AU - Kasahara, Kazuo

AU - Izumi, Shinyu

AU - Shiraki, Akira

AU - Miyamoto, Atsushi

AU - Kishi, Kazuma

AU - Kishaba, Tomoo

AU - Sugimoto, Chikatosi

AU - Inoue, Yoshikazu

AU - Kataoka, Kensuke

AU - Kondoh, Yasuhiro

AU - Tsuchiya, Yutaka

AU - Baba, Tomohisa

AU - Sugiura, Hiroaki

AU - Tanaka, Tomonori

AU - Sumikawa, Hiromitsu

AU - Suda, Takafumi

PY - 2019/12/1

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N2 - Thoracic diseases in patients with systemic lupus erythematosus (SLE), especially interstitial pneumonia (SLE-IP), are rare and have been poorly studied. The aims of this multicentre study were to evaluate SLE-IP and elucidate its clinical characteristics and prognosis. Fifty-five patients with SLE-IP who had attended the respiratory departments of participating hospitals were retrospectively evaluated in this multicentre study. Clinical information, high-resolution computed tomography (HRCT), and surgical lung biopsy/autopsy specimens were analysed by respiratory physicians, pulmonary radiologists, and pulmonary pathologists. IP patterns on HRCT and lung specimens were classified based on the international classification statement/guideline for idiopathic interstitial pneumonias. The most frequent form of SLE-IP at diagnosis was chronic IP (63.6%), followed by subacute (20.0%), and acute IP (12.7%). Radiologically, the most common HRCT pattern was “Unclassifiable” (54%). Histologically, “Unclassifiable” was the most frequently found (41.7%) among 12 patients with histologically proven IP. Interestingly, accompanying airway diseases were present in nine of these patients (75%). In multivariate analysis, current smoking (hazard ratio [HR] 6.105, p = 0.027), thrombocytopenia (HR 7.676, p = 0.010), anti-double-strand DNA titre (HR 0.956, p = 0.027), and nonspecific interstitial pneumonia (NSIP) + organizing pneumonia (OP) pattern on HRCT (vs. NSIP, HR 0.089, p = 0.023) were significant prognostic factors. In conclusion, chronic IP was the most frequent form of IP in patients with SLE-IP, and “Unclassifiable” was the commonest pattern radiologically and histologically.

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