Analysis of the association between galectin-3 concentration in tears and the severity of dry eye disease: A case-control study

Miki Hata-Mizuno, Yuichi Uchino, Miki Uchino, Shigeto Shimmura, Yoko Ogawa, Kazuo Tsubota, Kazuno Negishi

Research output: Contribution to journalArticlepeer-review

Abstract

This study aimed to investigate the relationship between the severity of dry eye disease (DED) and galectin-3 concentration (gal-3) and its cleavage (gal-3C) in tear fluid. Twenty-eight DED patients and 14 controls were recruited at Keio University Hospital. The lissamine green conjunctival staining (LG) score, fluorescein corneal staining (FL) score, tear film break-up time (TBUT), Schirmer’s test, and ocular symptoms questionnaire score (dry eye questionnaire score, DEQS) were evaluated. Furthermore, the correlation between these parameters and the concentrations of gal-3 in tears (ng/µg) and the detection rate of gal-3C (%) were analyzed. Gal-3 concentration in tears was positively correlated with the LG score (R = 0.60, p < 0.01), FL score (R = 0.49, p < 0.01), and DEQS (R = 0.45, p < 0.01), and negatively correlated with the TBUT score (R = −0.40, p <0.01) and Schirmer’s I value (R = −0.36, p < 0.01). The detection rate of gal-3C in tears was significantly associated with the severity of DED, especially with the LG (p < 0.01) and FL (p < 0.01) scores. Therefore, the concentration of gal-3 and the detection rate of gal-3C in tears had a significant relationship with the severity of ocular surface barrier disruption.

Original languageEnglish
Article number66
JournalJournal of Clinical Medicine
Volume11
Issue number1
DOIs
Publication statusPublished - 2022 Jan 1

Keywords

  • Dry eye disease
  • Dry eye syndrome
  • Galectin-3
  • Galectin-3C
  • Keratitis sicca
  • Keratoconjunctivitis sicca

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint

Dive into the research topics of 'Analysis of the association between galectin-3 concentration in tears and the severity of dry eye disease: A case-control study'. Together they form a unique fingerprint.

Cite this