Analysis of the bacterial flora in the nasal cavity and the sphenoid sinus mucosa in patients operated on with an endoscopic endonasal transsphenoidal approach

Shunsuke Shibao, Masahiro Toda, Toshiki Tomita, Kaoru Ogawa, Kazunari Yoshida

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6 Citations (Scopus)


The aim of this study was to analyze the bacterial flora in the nasal cavity and sphenoid sinus and evaluate the sensitivity of these bacteria to antibiotics that can be used to prevent postoperative meningitis. Bacteria of the preoperative nasal cavity and intraoperative sphenoid sinus mucosa were cultured and analyzed in 40 patients (20 men and 20 women; mean age, 52.2 years) who underwent endoscopic transsphenoidal surgery. The sensitivity of these bacteria to cephalosporin, a representative prophylactic antibiotic, was examined. Staphylococcus epidermidis was the most frequently detected species in both spaces; 24 (38.7%) of 62 isolates in the nasal cavity and 26 (37.1%) of 70 isolates in the sphenoid sinus. In contrast, Corynebacterium species were found mainly in the nasal cavity, and anaerobic bacteria were found only in the sphenoid sinus. Bacteria that were resistant to cephalosporin were found in the nasal cavity in 3.2% of patients and in the sphenoid sinus in 20% of patients. In conclusion, the composition of bacterial flora, including bacteria that are resistant to prophylactic antibiotics, differs between the nasal cavity and the sphenoid sinus.

Original languageEnglish
Pages (from-to)1009-1013
Number of pages5
JournalNeurologia medico-chirurgica
Issue number12
Publication statusPublished - 2014 Dec 15



  • Bacterial flora
  • Endoscopic endonasal transsphenoidal approach
  • Nasal cavity
  • Postoperative meningitis
  • Sphenoid sinus

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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