Analysis of the color patterns of early gastric cancer Using an autofluorescence imaging video endoscopy system

Motohiko Kato, Noriya Uedo, Ryu Ishihara, Takashi Kizu, Rika Chatani, Takuya Inoue, Eriko Masuda, Koichi Tatsumi, Yoji Takeuchi, Koji Higashino, Hiroyasu Iishi, Yasuhiko Tomita, Masaharu Tatsuta

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background. Using a novel autofluorescence imaging video endoscopy system (AFI), tumors in the esophagus and the colon appeared purple in a green background, but the color patterns of early gastric cancer (EGC) were found to vary. Factors associated with these patterns remain unknown. The aims of the present study were to classify the color patterns of EGCs and to investigate the correlation between the patterns and clinicopathological features. Methods. A total of 107 EGCs that had been evaluated by AFI endoscopy, prior to endoscopic or surgical resection, were included. The color patterns of EGCs in AFI images and the association between tumor color and clinicopathological factors were evaluated. These factors included tumor morphology, location, size, background color, histological type, depth of invasion, lymphatic or vessel permeation, and ulceration. Results. The color patterns of EGCs were classified into the following four groups: purple tumors in a green background (52%); green tumors with a purple margin in a green background (21%); green tumors in a purple background (17%); and purple tumors in a purple background (10%). Univariate analysis showed that macroscopic type, histological type, ulceration, and background AFI color were significantly associated with tumor color, whereas multivariate analysis revealed that macroscopic type was the only independent contributor to tumor color. Conclusion. The present study has enabled a clearer understanding of the significance of tumor color in relation to the AFI imaging of EGCs. Recognition of the color patterns in AFI images should help in the diagnosis of EGCs.

Original languageEnglish
Pages (from-to)219-224
Number of pages6
JournalGastric Cancer
Volume12
Issue number4
DOIs
Publication statusPublished - 2009 Dec 1
Externally publishedYes

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Optical Imaging
Endoscopy
Stomach Neoplasms
Color
Neoplasms
Lymphatic Vessels
Esophagus
Colon
Multivariate Analysis

Keywords

  • Atrophic gastritis
  • Autofluorescence endoscopy
  • Early gastric cancer
  • Tumor color patterns

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Cancer Research

Cite this

Kato, M., Uedo, N., Ishihara, R., Kizu, T., Chatani, R., Inoue, T., ... Tatsuta, M. (2009). Analysis of the color patterns of early gastric cancer Using an autofluorescence imaging video endoscopy system. Gastric Cancer, 12(4), 219-224. https://doi.org/10.1007/s10120-009-0529-4

Analysis of the color patterns of early gastric cancer Using an autofluorescence imaging video endoscopy system. / Kato, Motohiko; Uedo, Noriya; Ishihara, Ryu; Kizu, Takashi; Chatani, Rika; Inoue, Takuya; Masuda, Eriko; Tatsumi, Koichi; Takeuchi, Yoji; Higashino, Koji; Iishi, Hiroyasu; Tomita, Yasuhiko; Tatsuta, Masaharu.

In: Gastric Cancer, Vol. 12, No. 4, 01.12.2009, p. 219-224.

Research output: Contribution to journalArticle

Kato, M, Uedo, N, Ishihara, R, Kizu, T, Chatani, R, Inoue, T, Masuda, E, Tatsumi, K, Takeuchi, Y, Higashino, K, Iishi, H, Tomita, Y & Tatsuta, M 2009, 'Analysis of the color patterns of early gastric cancer Using an autofluorescence imaging video endoscopy system', Gastric Cancer, vol. 12, no. 4, pp. 219-224. https://doi.org/10.1007/s10120-009-0529-4
Kato, Motohiko ; Uedo, Noriya ; Ishihara, Ryu ; Kizu, Takashi ; Chatani, Rika ; Inoue, Takuya ; Masuda, Eriko ; Tatsumi, Koichi ; Takeuchi, Yoji ; Higashino, Koji ; Iishi, Hiroyasu ; Tomita, Yasuhiko ; Tatsuta, Masaharu. / Analysis of the color patterns of early gastric cancer Using an autofluorescence imaging video endoscopy system. In: Gastric Cancer. 2009 ; Vol. 12, No. 4. pp. 219-224.
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abstract = "Background. Using a novel autofluorescence imaging video endoscopy system (AFI), tumors in the esophagus and the colon appeared purple in a green background, but the color patterns of early gastric cancer (EGC) were found to vary. Factors associated with these patterns remain unknown. The aims of the present study were to classify the color patterns of EGCs and to investigate the correlation between the patterns and clinicopathological features. Methods. A total of 107 EGCs that had been evaluated by AFI endoscopy, prior to endoscopic or surgical resection, were included. The color patterns of EGCs in AFI images and the association between tumor color and clinicopathological factors were evaluated. These factors included tumor morphology, location, size, background color, histological type, depth of invasion, lymphatic or vessel permeation, and ulceration. Results. The color patterns of EGCs were classified into the following four groups: purple tumors in a green background (52{\%}); green tumors with a purple margin in a green background (21{\%}); green tumors in a purple background (17{\%}); and purple tumors in a purple background (10{\%}). Univariate analysis showed that macroscopic type, histological type, ulceration, and background AFI color were significantly associated with tumor color, whereas multivariate analysis revealed that macroscopic type was the only independent contributor to tumor color. Conclusion. The present study has enabled a clearer understanding of the significance of tumor color in relation to the AFI imaging of EGCs. Recognition of the color patterns in AFI images should help in the diagnosis of EGCs.",
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AU - Inoue, Takuya

AU - Masuda, Eriko

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