Analysis of the neurofibromatosis 2 gene in human breast and hepatocellular carcinomas.

Yae Kanai, H. Tsuda, T. Oda, Michiie Sakamoto, S. Hirohashi

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The neurofibromatosis 2 gene (NF2) mapped to chromosome 22q is a recently isolated tumor suppressor gene that participates in the tumorigenesis of cells of embryonic neural crest origin. The structural similarities between the NF2 product, merlin-schwannomin, and the band 4.1 family raise the possibility that merlin may participate in a wide range of cell activities, in which the cytoskeleton latticework has important roles to play. In order to examine the significance of NF2 in general carcinogenesis, comprehensive analyses of 68 cases of breast carcinoma, which shows frequent loss of heterozygosity at chromosome 22, and 48 hepatocellular carcinomas of different histological grade were performed. No mutation was detected by the polymerase chain reaction-single-strand conformation polymorphism method for six exons of NF2 in any of the cases examined, suggesting that NF2 may be less important in the tumorigenesis of breast and liver cancers than in that of cancers originating from the neural crest.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalJapanese Journal of Clinical Oncology
Volume25
Issue number1
Publication statusPublished - 1995 Feb
Externally publishedYes

Fingerprint

Neurofibromatosis 2 Genes
Neurofibromin 2
Hepatocellular Carcinoma
Breast Neoplasms
Carcinogenesis
Neural Crest
Chromosomes, Human, Pair 22
Loss of Heterozygosity
Liver Neoplasms
Tumor Suppressor Genes
Cytoskeleton
Exons
Chromosomes
Polymerase Chain Reaction
Mutation
Neoplasms

ASJC Scopus subject areas

  • Oncology

Cite this

Analysis of the neurofibromatosis 2 gene in human breast and hepatocellular carcinomas. / Kanai, Yae; Tsuda, H.; Oda, T.; Sakamoto, Michiie; Hirohashi, S.

In: Japanese Journal of Clinical Oncology, Vol. 25, No. 1, 02.1995, p. 1-4.

Research output: Contribution to journalArticle

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