Abstract
Recently, ultrasound contrast imaging has been improved greatly, because its application of an approach for therapy is urgently required for area of the heart and abdominal. Sonoporation is also one of the applications using microbubbles that attracts attention in the world. There have been so many studies for understanding the mechanism of sonoporation and improving efficiency of ultrasound contrast agents. Nonspherical oscillation is at a stage before the breakup process of microbubbles. Therefore, consideration of a microbubble's nonspherical oscillation is absolutely imperative for its future development. Thus in this thesis, the author regarded microbubbles as two dimensional air-liquid two-phase flow and calculated their dynamics by using Computational Fluid Dynamics (CFD). Numerical calculation of a microbubble's oscillation and deformation was also carried out, for an air bubble and for a shell-coated bubble in ultrasound field. As a result, it was confirmed that the CFD method developed in this study can be useful for analyzing an insonified microbubble showing nonspherical oscillation.
| Original language | English |
|---|---|
| Pages (from-to) | 1327-1335 |
| Number of pages | 9 |
| Journal | Nihon Kikai Gakkai Ronbunshu, C Hen/Transactions of the Japan Society of Mechanical Engineers, Part C |
| Volume | 79 |
| Issue number | 801 |
| DOIs | |
| Publication status | Published - 2013 |
| Externally published | Yes |
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Keywords
- Computational fluid dynamics
- Contrast agents
- Forced vibration
- Gas-liquid two-phase flow
- Lipid shell
- Micro-bubble
- Nonlinear oscillation
- Ultrasound
ASJC Scopus subject areas
- Mechanical Engineering
- Mechanics of Materials
- Industrial and Manufacturing Engineering
Cite this
Analysis on nonspherical oscillation of microbubble with two-dimensional numerical fluid simulation. / Kubo, Hiroki; Tsuruoka, Akira; Terada, Kei; Sugiura, Toshihiko.
In: Nihon Kikai Gakkai Ronbunshu, C Hen/Transactions of the Japan Society of Mechanical Engineers, Part C, Vol. 79, No. 801, 2013, p. 1327-1335.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Analysis on nonspherical oscillation of microbubble with two-dimensional numerical fluid simulation
AU - Kubo, Hiroki
AU - Tsuruoka, Akira
AU - Terada, Kei
AU - Sugiura, Toshihiko
PY - 2013
Y1 - 2013
N2 - Recently, ultrasound contrast imaging has been improved greatly, because its application of an approach for therapy is urgently required for area of the heart and abdominal. Sonoporation is also one of the applications using microbubbles that attracts attention in the world. There have been so many studies for understanding the mechanism of sonoporation and improving efficiency of ultrasound contrast agents. Nonspherical oscillation is at a stage before the breakup process of microbubbles. Therefore, consideration of a microbubble's nonspherical oscillation is absolutely imperative for its future development. Thus in this thesis, the author regarded microbubbles as two dimensional air-liquid two-phase flow and calculated their dynamics by using Computational Fluid Dynamics (CFD). Numerical calculation of a microbubble's oscillation and deformation was also carried out, for an air bubble and for a shell-coated bubble in ultrasound field. As a result, it was confirmed that the CFD method developed in this study can be useful for analyzing an insonified microbubble showing nonspherical oscillation.
AB - Recently, ultrasound contrast imaging has been improved greatly, because its application of an approach for therapy is urgently required for area of the heart and abdominal. Sonoporation is also one of the applications using microbubbles that attracts attention in the world. There have been so many studies for understanding the mechanism of sonoporation and improving efficiency of ultrasound contrast agents. Nonspherical oscillation is at a stage before the breakup process of microbubbles. Therefore, consideration of a microbubble's nonspherical oscillation is absolutely imperative for its future development. Thus in this thesis, the author regarded microbubbles as two dimensional air-liquid two-phase flow and calculated their dynamics by using Computational Fluid Dynamics (CFD). Numerical calculation of a microbubble's oscillation and deformation was also carried out, for an air bubble and for a shell-coated bubble in ultrasound field. As a result, it was confirmed that the CFD method developed in this study can be useful for analyzing an insonified microbubble showing nonspherical oscillation.
KW - Computational fluid dynamics
KW - Contrast agents
KW - Forced vibration
KW - Gas-liquid two-phase flow
KW - Lipid shell
KW - Micro-bubble
KW - Nonlinear oscillation
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=84879950704&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879950704&partnerID=8YFLogxK
U2 - 10.1299/kikaic.79.1327
DO - 10.1299/kikaic.79.1327
M3 - Article
AN - SCOPUS:84879950704
VL - 79
SP - 1327
EP - 1335
JO - Nihon Kikai Gakkai Ronbunshu, C Hen/Transactions of the Japan Society of Mechanical Engineers, Part C
JF - Nihon Kikai Gakkai Ronbunshu, C Hen/Transactions of the Japan Society of Mechanical Engineers, Part C
SN - 0387-5024
IS - 801
ER -