Anatomical resections are superior to wedge resections for overall survival in patients with Stage 1 typical carcinoids

Pier Luigi Filosso, Francesco Guerrera, Nicola Rosario Falco, Pascal Thomas, Mariano Garcia Yuste, Gaetano Rocco, Stefan Welter, Paula Moreno Casado, Erino Angelo Rendina, Federico Venuta, Luca Ampollini, Mario Nosotti, Federico Raveglia, Ottavio Rena, Franco Stella, Valentina Larocca, Francesco Ardissone, Alessandro Brunelli, Stefano Margaritora, William D. TravisDariusz Sagan, Inderpal Sarkaria, Andrea Evangelista, Mariano Garcia Yuste, Eric Lim, Konstantinos Papagiannopoulos, Hisao Asamura

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

OBJECTIVES: Typical carcinoids (TCs) are rare, slow-growing neoplasms, usually characterized by satisfactory surgical outcomes. Due to the rarity of TCs, international guidelines for the management of particular clinical presentations currently do not exist. In particular, nonanatomical resections (wedges) are sometimes advocated for Stage 1 TCs because of their indolent behaviour. The aim of this paper was to evaluate the most effective type of surgery for Stage 1 TCs, using the European Society of Thoracic Surgeons retrospective database of the Neuroendocrine Tumors of the Lung Working Group. METHODS: We analysed the effect of surgical procedure on the survival of patients with Stage 1 TCs. Overall survival (OS) was calculated from the date of intervention. The cumulative incidence of cause-specific death (tumour- and non-tumour-related) was also estimated. The impact of the surgical procedure (i.e. lobectomy vs segmentectomy vs wedge resection) on survival was investigated using the Cox model with shared frailty (for OS, accounting for the within-centre correlation) and the Fine and Gray model (for cause-specific mortality) using the approach based on the multinomial propensity score. Effects were estimated including in the model the logit-transformed propensity scores of segmentectomy and wedge resection as covariates. RESULTS: A total of 876 patients with Stage 1 TCs (569 women, 65%) were included in this study. The median age was 60 years (interquartile range 47-69). At the last follow-up, 66 patients had died: The 5-year OS rate was 94.3% [95% confidence interval (CI) 92.2-95.9]. The 5-year cumulative incidences of tumour- and non-tumour-related deaths were 2.4% (95% CI 1.4-3.9) and 3.9% (95% CI 2.5-5.6%), respectively. The analysis performed using the multinomial propensity score approach confirmed the significantly worse survival of patients treated with a wedge resection compared to those treated with a lobectomy (hazard ratio 2.01, 95% CI 1.09-3.69; P = 0.024). Similar effects of wedge resection are detectable for cause-specific deaths: tumour-related (hazard ratio 2.28, 95% CI 0.86-6.02; P = 0.096) and non-tumour-related (hazard ratio 1.74, 95% CI 0.89-3.40; P = 0.105). CONCLUSIONS: In a large cohort of patients, we were able to demonstrate the superiority of anatomical surgical resection in Stage 1 TCs in terms of OS. This result should therefore be considered for future clinical guidelines for the management of TCs.

Original languageEnglish
Pages (from-to)273-279
Number of pages7
JournalEuropean Journal of Cardio-thoracic Surgery
Volume55
Issue number2
DOIs
Publication statusPublished - 2019 Feb 1
Externally publishedYes

Fingerprint

Carcinoid Tumor
Survival
Confidence Intervals
Propensity Score
Segmental Mastectomy
Cause of Death
Neoplasms
Guidelines
Neuroendocrine Tumors
Incidence
Proportional Hazards Models
Survival Rate
Logistic Models
Databases
Lung
Mortality

Keywords

  • Lung
  • Neoplasm
  • Overall survival
  • Surgery
  • Typical carcinoid

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Anatomical resections are superior to wedge resections for overall survival in patients with Stage 1 typical carcinoids. / Filosso, Pier Luigi; Guerrera, Francesco; Falco, Nicola Rosario; Thomas, Pascal; Garcia Yuste, Mariano; Rocco, Gaetano; Welter, Stefan; Moreno Casado, Paula; Rendina, Erino Angelo; Venuta, Federico; Ampollini, Luca; Nosotti, Mario; Raveglia, Federico; Rena, Ottavio; Stella, Franco; Larocca, Valentina; Ardissone, Francesco; Brunelli, Alessandro; Margaritora, Stefano; Travis, William D.; Sagan, Dariusz; Sarkaria, Inderpal; Evangelista, Andrea; Yuste, Mariano Garcia; Lim, Eric; Papagiannopoulos, Konstantinos; Asamura, Hisao.

In: European Journal of Cardio-thoracic Surgery, Vol. 55, No. 2, 01.02.2019, p. 273-279.

Research output: Contribution to journalArticle

Filosso, PL, Guerrera, F, Falco, NR, Thomas, P, Garcia Yuste, M, Rocco, G, Welter, S, Moreno Casado, P, Rendina, EA, Venuta, F, Ampollini, L, Nosotti, M, Raveglia, F, Rena, O, Stella, F, Larocca, V, Ardissone, F, Brunelli, A, Margaritora, S, Travis, WD, Sagan, D, Sarkaria, I, Evangelista, A, Yuste, MG, Lim, E, Papagiannopoulos, K & Asamura, H 2019, 'Anatomical resections are superior to wedge resections for overall survival in patients with Stage 1 typical carcinoids', European Journal of Cardio-thoracic Surgery, vol. 55, no. 2, pp. 273-279. https://doi.org/10.1093/ejcts/ezy250
Filosso, Pier Luigi ; Guerrera, Francesco ; Falco, Nicola Rosario ; Thomas, Pascal ; Garcia Yuste, Mariano ; Rocco, Gaetano ; Welter, Stefan ; Moreno Casado, Paula ; Rendina, Erino Angelo ; Venuta, Federico ; Ampollini, Luca ; Nosotti, Mario ; Raveglia, Federico ; Rena, Ottavio ; Stella, Franco ; Larocca, Valentina ; Ardissone, Francesco ; Brunelli, Alessandro ; Margaritora, Stefano ; Travis, William D. ; Sagan, Dariusz ; Sarkaria, Inderpal ; Evangelista, Andrea ; Yuste, Mariano Garcia ; Lim, Eric ; Papagiannopoulos, Konstantinos ; Asamura, Hisao. / Anatomical resections are superior to wedge resections for overall survival in patients with Stage 1 typical carcinoids. In: European Journal of Cardio-thoracic Surgery. 2019 ; Vol. 55, No. 2. pp. 273-279.
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TY - JOUR

T1 - Anatomical resections are superior to wedge resections for overall survival in patients with Stage 1 typical carcinoids

AU - Filosso, Pier Luigi

AU - Guerrera, Francesco

AU - Falco, Nicola Rosario

AU - Thomas, Pascal

AU - Garcia Yuste, Mariano

AU - Rocco, Gaetano

AU - Welter, Stefan

AU - Moreno Casado, Paula

AU - Rendina, Erino Angelo

AU - Venuta, Federico

AU - Ampollini, Luca

AU - Nosotti, Mario

AU - Raveglia, Federico

AU - Rena, Ottavio

AU - Stella, Franco

AU - Larocca, Valentina

AU - Ardissone, Francesco

AU - Brunelli, Alessandro

AU - Margaritora, Stefano

AU - Travis, William D.

AU - Sagan, Dariusz

AU - Sarkaria, Inderpal

AU - Evangelista, Andrea

AU - Yuste, Mariano Garcia

AU - Lim, Eric

AU - Papagiannopoulos, Konstantinos

AU - Asamura, Hisao

PY - 2019/2/1

Y1 - 2019/2/1

N2 - OBJECTIVES: Typical carcinoids (TCs) are rare, slow-growing neoplasms, usually characterized by satisfactory surgical outcomes. Due to the rarity of TCs, international guidelines for the management of particular clinical presentations currently do not exist. In particular, nonanatomical resections (wedges) are sometimes advocated for Stage 1 TCs because of their indolent behaviour. The aim of this paper was to evaluate the most effective type of surgery for Stage 1 TCs, using the European Society of Thoracic Surgeons retrospective database of the Neuroendocrine Tumors of the Lung Working Group. METHODS: We analysed the effect of surgical procedure on the survival of patients with Stage 1 TCs. Overall survival (OS) was calculated from the date of intervention. The cumulative incidence of cause-specific death (tumour- and non-tumour-related) was also estimated. The impact of the surgical procedure (i.e. lobectomy vs segmentectomy vs wedge resection) on survival was investigated using the Cox model with shared frailty (for OS, accounting for the within-centre correlation) and the Fine and Gray model (for cause-specific mortality) using the approach based on the multinomial propensity score. Effects were estimated including in the model the logit-transformed propensity scores of segmentectomy and wedge resection as covariates. RESULTS: A total of 876 patients with Stage 1 TCs (569 women, 65%) were included in this study. The median age was 60 years (interquartile range 47-69). At the last follow-up, 66 patients had died: The 5-year OS rate was 94.3% [95% confidence interval (CI) 92.2-95.9]. The 5-year cumulative incidences of tumour- and non-tumour-related deaths were 2.4% (95% CI 1.4-3.9) and 3.9% (95% CI 2.5-5.6%), respectively. The analysis performed using the multinomial propensity score approach confirmed the significantly worse survival of patients treated with a wedge resection compared to those treated with a lobectomy (hazard ratio 2.01, 95% CI 1.09-3.69; P = 0.024). Similar effects of wedge resection are detectable for cause-specific deaths: tumour-related (hazard ratio 2.28, 95% CI 0.86-6.02; P = 0.096) and non-tumour-related (hazard ratio 1.74, 95% CI 0.89-3.40; P = 0.105). CONCLUSIONS: In a large cohort of patients, we were able to demonstrate the superiority of anatomical surgical resection in Stage 1 TCs in terms of OS. This result should therefore be considered for future clinical guidelines for the management of TCs.

AB - OBJECTIVES: Typical carcinoids (TCs) are rare, slow-growing neoplasms, usually characterized by satisfactory surgical outcomes. Due to the rarity of TCs, international guidelines for the management of particular clinical presentations currently do not exist. In particular, nonanatomical resections (wedges) are sometimes advocated for Stage 1 TCs because of their indolent behaviour. The aim of this paper was to evaluate the most effective type of surgery for Stage 1 TCs, using the European Society of Thoracic Surgeons retrospective database of the Neuroendocrine Tumors of the Lung Working Group. METHODS: We analysed the effect of surgical procedure on the survival of patients with Stage 1 TCs. Overall survival (OS) was calculated from the date of intervention. The cumulative incidence of cause-specific death (tumour- and non-tumour-related) was also estimated. The impact of the surgical procedure (i.e. lobectomy vs segmentectomy vs wedge resection) on survival was investigated using the Cox model with shared frailty (for OS, accounting for the within-centre correlation) and the Fine and Gray model (for cause-specific mortality) using the approach based on the multinomial propensity score. Effects were estimated including in the model the logit-transformed propensity scores of segmentectomy and wedge resection as covariates. RESULTS: A total of 876 patients with Stage 1 TCs (569 women, 65%) were included in this study. The median age was 60 years (interquartile range 47-69). At the last follow-up, 66 patients had died: The 5-year OS rate was 94.3% [95% confidence interval (CI) 92.2-95.9]. The 5-year cumulative incidences of tumour- and non-tumour-related deaths were 2.4% (95% CI 1.4-3.9) and 3.9% (95% CI 2.5-5.6%), respectively. The analysis performed using the multinomial propensity score approach confirmed the significantly worse survival of patients treated with a wedge resection compared to those treated with a lobectomy (hazard ratio 2.01, 95% CI 1.09-3.69; P = 0.024). Similar effects of wedge resection are detectable for cause-specific deaths: tumour-related (hazard ratio 2.28, 95% CI 0.86-6.02; P = 0.096) and non-tumour-related (hazard ratio 1.74, 95% CI 0.89-3.40; P = 0.105). CONCLUSIONS: In a large cohort of patients, we were able to demonstrate the superiority of anatomical surgical resection in Stage 1 TCs in terms of OS. This result should therefore be considered for future clinical guidelines for the management of TCs.

KW - Lung

KW - Neoplasm

KW - Overall survival

KW - Surgery

KW - Typical carcinoid

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