TY - JOUR
T1 - Andrastins A∼C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929
T2 - I. Producing strain, fermentation, isolation, and biological activities
AU - Omura, Satoshi
AU - Inokoshi, Junji
AU - Uchida, Ryuji
AU - Shiomi, Kazuro
AU - Masuma, Rokuro
AU - Kawakubo, Tomoya
AU - Tanaka, Haruo
AU - Iwai, Yuzuru
AU - Kosemura, Seiji
AU - Yamamura, Shosuke
PY - 1996/5
Y1 - 1996/5
N2 - New protein farnesyltransferase inhibitors, andrastins A∼C, have been discovered in the cultured broth of Penicillium sp. FO-3929. Andrastins extracted from broth supernatant were purified by silica gel chromatography, ODS chromatography and HPLC. The IC50 of andrastins A, B, and C against protein farnesyltransferase were 24.9, 47.1, and 13.3 μM, respectively.
AB - New protein farnesyltransferase inhibitors, andrastins A∼C, have been discovered in the cultured broth of Penicillium sp. FO-3929. Andrastins extracted from broth supernatant were purified by silica gel chromatography, ODS chromatography and HPLC. The IC50 of andrastins A, B, and C against protein farnesyltransferase were 24.9, 47.1, and 13.3 μM, respectively.
UR - http://www.scopus.com/inward/record.url?scp=0029895236&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029895236&partnerID=8YFLogxK
U2 - 10.7164/antibiotics.49.414
DO - 10.7164/antibiotics.49.414
M3 - Article
C2 - 8682716
AN - SCOPUS:0029895236
SN - 0021-8820
VL - 49
SP - 414
EP - 417
JO - Journal of Antibiotics
JF - Journal of Antibiotics
IS - 5
ER -