Andrastins A∼C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929: I. Producing strain, fermentation, isolation, and biological activities

Satoshi Omura, Junji Inokoshi, Ryuji Uchida, Kazuro Shiomi, Rokuro Masuma, Tomoya Kawakubo, Haruo Tanaka, Yuzuru Iwai, Seiji Kosemura, Shosuke Yamamura

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

New protein farnesyltransferase inhibitors, andrastins A∼C, have been discovered in the cultured broth of Penicillium sp. FO-3929. Andrastins extracted from broth supernatant were purified by silica gel chromatography, ODS chromatography and HPLC. The IC50 of andrastins A, B, and C against protein farnesyltransferase were 24.9, 47.1, and 13.3 μM, respectively.

Original languageEnglish
Pages (from-to)414-417
Number of pages4
JournalJournal of Antibiotics
Volume49
Issue number5
Publication statusPublished - 1996 May

Fingerprint

Penicillium
Fermentation
Silica Gel
Inhibitory Concentration 50
Gel Chromatography
Chromatography
High Pressure Liquid Chromatography
p21(ras) farnesyl-protein transferase
andrastin A
andrastin C
andrastin B

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Andrastins A∼C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929 : I. Producing strain, fermentation, isolation, and biological activities. / Omura, Satoshi; Inokoshi, Junji; Uchida, Ryuji; Shiomi, Kazuro; Masuma, Rokuro; Kawakubo, Tomoya; Tanaka, Haruo; Iwai, Yuzuru; Kosemura, Seiji; Yamamura, Shosuke.

In: Journal of Antibiotics, Vol. 49, No. 5, 05.1996, p. 414-417.

Research output: Contribution to journalArticle

Omura, S, Inokoshi, J, Uchida, R, Shiomi, K, Masuma, R, Kawakubo, T, Tanaka, H, Iwai, Y, Kosemura, S & Yamamura, S 1996, 'Andrastins A∼C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929: I. Producing strain, fermentation, isolation, and biological activities', Journal of Antibiotics, vol. 49, no. 5, pp. 414-417.
Omura, Satoshi ; Inokoshi, Junji ; Uchida, Ryuji ; Shiomi, Kazuro ; Masuma, Rokuro ; Kawakubo, Tomoya ; Tanaka, Haruo ; Iwai, Yuzuru ; Kosemura, Seiji ; Yamamura, Shosuke. / Andrastins A∼C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929 : I. Producing strain, fermentation, isolation, and biological activities. In: Journal of Antibiotics. 1996 ; Vol. 49, No. 5. pp. 414-417.
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AU - Kawakubo, Tomoya

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