Andrastins A∼C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929: I. Producing strain, fermentation, isolation, and biological activities

Satoshi Omura, Junji Inokoshi, Ryuji Uchida, Kazuro Shiomi, Rokuro Masuma, Tomoya Kawakubo, Haruo Tanaka, Yuzuru Iwai, Seiji Kosemura, Shosuke Yamamura

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New protein farnesyltransferase inhibitors, andrastins A∼C, have been discovered in the cultured broth of Penicillium sp. FO-3929. Andrastins extracted from broth supernatant were purified by silica gel chromatography, ODS chromatography and HPLC. The IC50 of andrastins A, B, and C against protein farnesyltransferase were 24.9, 47.1, and 13.3 μM, respectively.

Original languageEnglish
Pages (from-to)414-417
Number of pages4
JournalJournal of Antibiotics
Issue number5
Publication statusPublished - 1996 May


ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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