Angiopoietin-like proteins: Potential new targets for metabolic syndrome therapy

Yuichi Oike, Masaki Akao, Yoshiaki Kubota, Toshio Suda

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Metabolic syndrome is an increasingly prevalent problem, so effective therapeutic approaches to combat it are currently of interest. Recently, orphan ligands with structural similarity to angiopoietins were identified in the systemic circulation, and have been designated angiopoietin-like proteins (Angptls). Angptl3 and Angptl4 have been shown to regulate fat, lipid or glucose metabolic homeostasis. More recently, AGF (also called Angptl6) has been shown to counteract obesity and related insulin resistance. Notably, these factors are secreted mainly from the liver and act as endocrine signals in the peripheral tissues, suggesting a new role for hepatocyte-derived factors in regulating metabolic homeostasis. As more is discovered about the functions of Angptls, so their potential as therapeutic targets for metabolic syndrome is explored.

Original languageEnglish
Pages (from-to)473-479
Number of pages7
JournalTrends in Molecular Medicine
Volume11
Issue number10
DOIs
Publication statusPublished - 2005

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Angiopoietins
Homeostasis
Proteins
Insulin Resistance
Hepatocytes
Therapeutics
Obesity
Fats
Ligands
Lipids
Glucose
Liver

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Angiopoietin-like proteins : Potential new targets for metabolic syndrome therapy. / Oike, Yuichi; Akao, Masaki; Kubota, Yoshiaki; Suda, Toshio.

In: Trends in Molecular Medicine, Vol. 11, No. 10, 2005, p. 473-479.

Research output: Contribution to journalArticle

Oike, Yuichi ; Akao, Masaki ; Kubota, Yoshiaki ; Suda, Toshio. / Angiopoietin-like proteins : Potential new targets for metabolic syndrome therapy. In: Trends in Molecular Medicine. 2005 ; Vol. 11, No. 10. pp. 473-479.
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