Angioscope visualization in blood vessel using Ho:YAG laser-induced vapor bubble

E. Yamashita, Y. Oka, K. Kaneko, E. Suga, T. Arai

Research output: Contribution to journalConference articlepeer-review


We proposed new method of blood removal using Ho:YAG laser(λ=2. 1μm)-induced water-vapor bubble to prevent distal tissue ischemia during angioscopic imaging. We successfully demonstrated capability of this blood removal method using blood-filled pocine coronary artery ex vivo. We used laser irradiation conditions of 200mJ in pulse energy and 2Hz in repetition rate. Ho:YAG laser for blood removal and flash lamp lighting for endoscopic illumination were irradiated in the porcine coronary artery through individual fiber optics. Timing of the flash lamp lightning of 2 μ s in duration was arranged to illuminate the maximum blood removal space, i.e. the laser induced water-vapor bubble. We successfully obtained intra-lumen view via a thin angioscope using the laser blood removal without using saline injection. We studied to determine the optimum laser-induced bubble formation which indicated the minimum invasion against the blood vessel. The time resolved photography In vitro, transient pressure measurement in vitro, and acute historogical study on irradiated vessel wall in vivo were employed for this determination.

Original languageEnglish
Article number95
Pages (from-to)447-452
Number of pages6
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Publication statusPublished - 2005 Aug 16
EventPhotonic Therapeutics and Diagnostics - San Jose, CA, United States
Duration: 2005 Jan 222005 Jan 25


  • Angioscope
  • Blood removal
  • Distal tissue ischemia
  • Ho: YAG laser
  • Laser-induced bubble
  • Optical diagnosis

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Angioscope visualization in blood vessel using Ho:YAG laser-induced vapor bubble'. Together they form a unique fingerprint.

Cite this