Angiotensin converting enzyme inhibitor normalizes vascular natriuretic peptide type A receptor gene expression via bradykinin-dependent mechanism in hypertensive rats

Takanobu Yoshimoto, Kiyoko Naruse, Kiseko Shionoya, Masami Tanaka, Toshiro Seki, Hiromi Hagiwara, Shigehisa Hirose, Lam Sau Kuen, Hiroshi Demura, Mitsuhide Naruse, Takamura Muraki

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We previously demonstrated that angiotensin converting enzyme (ACE) inhibitor normalizes the up-regulated gene expression of vascular natriuretic peptide type A (NP-A) receptor in hypertensive rats. To elucidate the mechanism, we examined the effect of angiotensin II receptor (AT1) antagonist (TCV-116) and bradykinin receptor (B2) antagonist (Hoe 140) on the NP-A receptor mRNA level in the aorta of genetically hypertensive rats (SHR-SP/Izm) using ribonuclease protection assay. The effect of ACE inhibitor on the NP-A receptor mRNA level was completely abolished by a concomitant administration of Hoe 140, while TCV-116 did not show any significant effect on the NP-A receptor mRNA level. These results suggest that bradykinin plays an important role in the regulation of the vascular NP-A receptor gene expression.

Original languageEnglish
Pages (from-to)50-53
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume218
Issue number1
DOIs
Publication statusPublished - 1996 Jan 5
Externally publishedYes

Fingerprint

Natriuretic Peptides
Peptide Receptors
Bradykinin
Angiotensin-Converting Enzyme Inhibitors
Gene expression
Blood Vessels
Rats
Gene Expression
Messenger RNA
Angiotensin Receptors
Angiotensin Receptor Antagonists
Inbred SHR Rats
Ribonucleases
Aorta
Assays
peptide A

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Angiotensin converting enzyme inhibitor normalizes vascular natriuretic peptide type A receptor gene expression via bradykinin-dependent mechanism in hypertensive rats. / Yoshimoto, Takanobu; Naruse, Kiyoko; Shionoya, Kiseko; Tanaka, Masami; Seki, Toshiro; Hagiwara, Hiromi; Hirose, Shigehisa; Kuen, Lam Sau; Demura, Hiroshi; Naruse, Mitsuhide; Muraki, Takamura.

In: Biochemical and Biophysical Research Communications, Vol. 218, No. 1, 05.01.1996, p. 50-53.

Research output: Contribution to journalArticle

Yoshimoto, Takanobu ; Naruse, Kiyoko ; Shionoya, Kiseko ; Tanaka, Masami ; Seki, Toshiro ; Hagiwara, Hiromi ; Hirose, Shigehisa ; Kuen, Lam Sau ; Demura, Hiroshi ; Naruse, Mitsuhide ; Muraki, Takamura. / Angiotensin converting enzyme inhibitor normalizes vascular natriuretic peptide type A receptor gene expression via bradykinin-dependent mechanism in hypertensive rats. In: Biochemical and Biophysical Research Communications. 1996 ; Vol. 218, No. 1. pp. 50-53.
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AU - Tanaka, Masami

AU - Seki, Toshiro

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AU - Hirose, Shigehisa

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