Angiotensin converting enzyme inhibitor normalizes vascular natriuretic peptide type A receptor gene expression via bradykinin-dependent mechanism in hypertensive rats

Takanobu Yoshimoto, Kiyoko Naruse, Kiseko Shionoya, Masami Tanaka, Toshiro Seki, Hiromi Hagiwara, Shigehisa Hirose, Lam Sau Kuen, Hiroshi Demura, Mitsuhide Naruse, Takamura Muraki

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6 Citations (Scopus)

Abstract

We previously demonstrated that angiotensin converting enzyme (ACE) inhibitor normalizes the up-regulated gene expression of vascular natriuretic peptide type A (NP-A) receptor in hypertensive rats. To elucidate the mechanism, we examined the effect of angiotensin II receptor (AT1) antagonist (TCV-116) and bradykinin receptor (B2) antagonist (Hoe 140) on the NP-A receptor mRNA level in the aorta of genetically hypertensive rats (SHR-SP/Izm) using ribonuclease protection assay. The effect of ACE inhibitor on the NP-A receptor mRNA level was completely abolished by a concomitant administration of Hoe 140, while TCV-116 did not show any significant effect on the NP-A receptor mRNA level. These results suggest that bradykinin plays an important role in the regulation of the vascular NP-A receptor gene expression.

Original languageEnglish
Pages (from-to)50-53
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume218
Issue number1
DOIs
Publication statusPublished - 1996 Jan 5
Externally publishedYes

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ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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