Angiotensin converting enzyme insertion/deletion polymorphism is associated with plasma antigen levels of plasminogen activator inhibitor-1 in healthy Japanese population

Yumiko Matsubara, T. Hayakawa, T. Tsuda, E. Takeshita, G. Watanabe, M. Murata, K. Watanabe, Y. Ikeda

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Plasminogen activator inhibitor-1 (PAI-1) has a central role in the regulation of the fibrinolytic enzyme system. An elevated plasma PAI-1 level is associated with thrombotic disorders. In vitro and in vivo studies indicate that the renin-angiotensin system is involved in the regulation of PAI-1. A 287-bp insertion/deletion (I/D) polymorphism in the gene-encoding angiotensin converting enzyme (ACE) is associated with cardiovascular disorders. We evaluated the association between the ACE I/D polymorphism and plasma PAI-1 antigen levels in 110 healthy Japanese male subjects. Subjects with the D-allele of the gene-encoding ACE had higher levels of PAI-1 (26.3 ± 14.7 ng/ml, mean ± standard deviation) compared with those without (21.0 ± 12.0; P = 0.0491). A multiple linear regression model with independent variables (age, body-mass index, total cholesterol level, triglyceride level, ACE I/D genotype, and PAI-1 genotype due to a single guanine I/D polymorphism in the PAI-1 gene) demonstrated that the triglyceride level (P = 0.0059) and ACE I/D genotype (P = 0.0372) were independent predictors of plasma PAI-1 antigen levels in a subset of the subjects without diabetes mellitus that were not taking lipid-lowering drugs. These findings suggest that the ACE I/D polymorphism is a genetic factor for the regulation of plasma PAI-1 antigen levels in the healthy Japanese population. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalBlood Coagulation and Fibrinolysis
Volume11
Issue number2
DOIs
Publication statusPublished - 2000 Jan 1

Keywords

  • Angiotensin converting enzyme
  • Genetics
  • Plasminogen activator inhibitor-1
  • Polymorphism
  • Renin-angiotensin system

ASJC Scopus subject areas

  • Hematology

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