Angiotensin II augments advanced glycation end product-induced pericyte apoptosis through RAGE overexpression

Sho Ichi Yamagishi; Masayoshi Takeuchi; Takanori Matsui; Kazuo Nakamura; Tsutomu Imaizumi; Hiroyoshi Inoue

doi:10.1016/j.febslet.2005.06.058

Angiotensin II augments advanced glycation end product-induced pericyte apoptosis through RAGE overexpression

Sho Ichi Yamagishi, Masayoshi Takeuchi, Takanori Matsui, Kazuo Nakamura, Tsutomu Imaizumi, Hiroyoshi Inoue

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

Abstract

Advanced glycation end product (AGE)-their receptor (RAGE) and angiotensin II (AII) are implicated in diabetic retinopathy. However, a crosstalk between the two is not fully understood. In vivo, AGE injection stimulated RAGE expression in the eye of spontaneously hypertensive rats, which was blocked by an AII-type 1 receptor blocker, telmisartan. In vitro, AII-type 1 receptor-mediated reactive oxygen species generation elicited RAGE gene expression in pericytes through NF-κB activation. Further, AII augmented AGE-induced pericyte apoptosis, the earliest hallmark of diabetic retinopathy. Our present study may implicate a crosstalk between AGE-RAGE system and AII in diabetic retinopathy.

Original language	English
Pages (from-to)	4265-4270
Number of pages	6
Journal	FEBS Letters
Volume	579
Issue number	20
DOIs	https://doi.org/10.1016/j.febslet.2005.06.058
Publication status	Published - 2005 Aug 15
Externally published	Yes

Keywords

Advanced glycation end products
Angiotensin II
Diabetic retinopathy
Oxidative stress
Pericyte loss
Receptor for AGEs

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.febslet.2005.06.058

Cite this

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title = "Angiotensin II augments advanced glycation end product-induced pericyte apoptosis through RAGE overexpression",

abstract = "Advanced glycation end product (AGE)-their receptor (RAGE) and angiotensin II (AII) are implicated in diabetic retinopathy. However, a crosstalk between the two is not fully understood. In vivo, AGE injection stimulated RAGE expression in the eye of spontaneously hypertensive rats, which was blocked by an AII-type 1 receptor blocker, telmisartan. In vitro, AII-type 1 receptor-mediated reactive oxygen species generation elicited RAGE gene expression in pericytes through NF-κB activation. Further, AII augmented AGE-induced pericyte apoptosis, the earliest hallmark of diabetic retinopathy. Our present study may implicate a crosstalk between AGE-RAGE system and AII in diabetic retinopathy.",

keywords = "Advanced glycation end products, Angiotensin II, Diabetic retinopathy, Oxidative stress, Pericyte loss, Receptor for AGEs",

author = "Yamagishi, {Sho Ichi} and Masayoshi Takeuchi and Takanori Matsui and Kazuo Nakamura and Tsutomu Imaizumi and Hiroyoshi Inoue",

note = "Funding Information: This work was supported in part by Grants of Collaboration with Venture Companies Project from the Ministry of Education, Culture, Sports, Science and Technology, Japan (S. Yamagishi).",

year = "2005",

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doi = "10.1016/j.febslet.2005.06.058",

language = "English",

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T1 - Angiotensin II augments advanced glycation end product-induced pericyte apoptosis through RAGE overexpression

AU - Yamagishi, Sho Ichi

AU - Takeuchi, Masayoshi

AU - Matsui, Takanori

AU - Nakamura, Kazuo

AU - Imaizumi, Tsutomu

AU - Inoue, Hiroyoshi

N1 - Funding Information: This work was supported in part by Grants of Collaboration with Venture Companies Project from the Ministry of Education, Culture, Sports, Science and Technology, Japan (S. Yamagishi).

PY - 2005/8/15

Y1 - 2005/8/15

N2 - Advanced glycation end product (AGE)-their receptor (RAGE) and angiotensin II (AII) are implicated in diabetic retinopathy. However, a crosstalk between the two is not fully understood. In vivo, AGE injection stimulated RAGE expression in the eye of spontaneously hypertensive rats, which was blocked by an AII-type 1 receptor blocker, telmisartan. In vitro, AII-type 1 receptor-mediated reactive oxygen species generation elicited RAGE gene expression in pericytes through NF-κB activation. Further, AII augmented AGE-induced pericyte apoptosis, the earliest hallmark of diabetic retinopathy. Our present study may implicate a crosstalk between AGE-RAGE system and AII in diabetic retinopathy.

AB - Advanced glycation end product (AGE)-their receptor (RAGE) and angiotensin II (AII) are implicated in diabetic retinopathy. However, a crosstalk between the two is not fully understood. In vivo, AGE injection stimulated RAGE expression in the eye of spontaneously hypertensive rats, which was blocked by an AII-type 1 receptor blocker, telmisartan. In vitro, AII-type 1 receptor-mediated reactive oxygen species generation elicited RAGE gene expression in pericytes through NF-κB activation. Further, AII augmented AGE-induced pericyte apoptosis, the earliest hallmark of diabetic retinopathy. Our present study may implicate a crosstalk between AGE-RAGE system and AII in diabetic retinopathy.

KW - Advanced glycation end products

KW - Angiotensin II

KW - Diabetic retinopathy

KW - Oxidative stress

KW - Pericyte loss

KW - Receptor for AGEs

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JF - FEBS Letters

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ER -

Angiotensin II augments advanced glycation end product-induced pericyte apoptosis through RAGE overexpression

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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