Angiotensin II type I antagonist prevents pulmonary metastasis of murine renal cancer by inhibiting tumor angiogenesis

Akira Miyajima, Takeo Kosaka, Tomohiko Asano, Takako Asano, Kaori Seta, Toshiaki Kawai, Masamichi Hayakawa

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150 Citations (Scopus)

Abstract

Angiotensin II (AII) is a potent vasoconstrictor peptide from the reninangiotensin system in the kidney. The AII type 1 receptor (AT1R) is reportedly expressed in several tumors including renal cell carcinoma, and AII is involved in tumor angiogenesis. We p.o. administered the long-acting AT1R antagonist, candesartan (10 mg/kg), to the 16 days mouse renal cancer lung metastasis model to test the preventive effects in tumor metastasis. Pulmonary metastases of renal cancer showed prominent AT1R expression in both mice and humans, and candesartan treatment dramatically prevented lung metastatic nodules (14.9 ± 1.8; P < 0.0001; n = 12) in mice along with the inhibition of neovascularization and vascular endothelial growth factor expression, compared with control metastatic mice (123.3 ± 8.6; n = 13). Candesartan is widely used clinically, so it seems to be a reasonable therapy for patients with lung metastases of renal cell carcinoma.

Original languageEnglish
Pages (from-to)4176-4179
Number of pages4
JournalCancer Research
Volume62
Issue number15
Publication statusPublished - 2002 Aug 1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Miyajima, A., Kosaka, T., Asano, T., Asano, T., Seta, K., Kawai, T., & Hayakawa, M. (2002). Angiotensin II type I antagonist prevents pulmonary metastasis of murine renal cancer by inhibiting tumor angiogenesis. Cancer Research, 62(15), 4176-4179.