Anodic Oxidation of Phenols: A Key Step for the Synthesis of Natural Products

Takashi Yamamoto, Tsuyoshi Saitoh, Yasuaki Einaga, Shigeru Nishiyama

Research output: Contribution to journalArticlepeer-review

Abstract

Natural products have played a significant role not only in discovery of drugs but also in development of organic chemistry by providing the synthetic challenges. Inspired by biosynthesis where enzymes catalyze a multi-step reaction, we have investigated the natural product synthesis utilizing electrochemical reactions as the key step. Electrochemical organic synthesis, so-called electro-organic synthesis, enables to control the reactivity of substrates simply by tuning electrolysis conditions. In this Personal Account, we overview the recent progress of our research projects about natural product synthesis, in which anodic oxidation of phenol compounds affords the important frameworks such as diaryl ether, spirodienone, and spiroisoxazoline.

Original languageEnglish
JournalChemical Record
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • Anodic oxidation
  • Diaryl ether
  • Natural products
  • Phenol
  • Spiro compounds

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry
  • Chemical Engineering(all)
  • Materials Chemistry

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