Antagonism between the vascular renin-angiotensin and natriuretic peptide systems in vascular remodelling

Hiroshi Itoh, K. Nakao

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Vascular remodelling is central to the pathophysiology of hypertension and atherosclerosis. Recent evidence suggests the pivotal role of vasoactive substances occurring in the blood vessel, such as angiotensin II (AII), in the control of vascular growth. We recently discovered that C-type natriuretic peptide (CNP), the third member of the natriuretic peptide family, is produced by vascular endothelial cells and can act as an endothelium-derived relaxing peptide. We also demonstrated gene expression of CNP and the ANP-B receptor, which is one of the three subtypes of the natriuretic peptide receptor and is specific to CNP in blood vessels in vivo. Thus, we propose the existence of a 'vascular natriuretic peptide system (NPS)' similar to the vascular renin-angiotensin system (RAS). The present study showed that CNP exerted a growth-inhibitory action and antagonised the growth-promoting action of AII, which was mediated through the AII subtype 1 receptor in cultured vascular smooth muscle cells. In neointimal lesions of rat carotid artery, CNP gene transcript was detectable 2 weeks after balloon injury, and ANP-B receptor gene expression was augmented. These findings suggest that the vascular NPS is activated in proliferative vascular lesions, suppressing further proliferation by antagonising the action of the vascular RAS.

Original languageEnglish
Pages (from-to)49-53
Number of pages5
JournalBlood Pressure, Supplement
Volume3
Issue number5
Publication statusPublished - 1994
Externally publishedYes

Fingerprint

Natriuretic Peptides
Angiotensins
Renin
C-Type Natriuretic Peptide
Blood Vessels
Atrial Natriuretic Factor Receptors
Angiotensin II
Renin-Angiotensin System
Growth
Gene Expression
Peptide Receptors
Vascular Remodeling
Vascular Smooth Muscle
Carotid Arteries
Smooth Muscle Myocytes
Endothelium
Atherosclerosis
Endothelial Cells
Hypertension
Peptides

Keywords

  • Angiotensin II
  • Balloon injury
  • Gene expression
  • Natriuretic peptide
  • Receptor
  • Vascular growth

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

Cite this

Antagonism between the vascular renin-angiotensin and natriuretic peptide systems in vascular remodelling. / Itoh, Hiroshi; Nakao, K.

In: Blood Pressure, Supplement, Vol. 3, No. 5, 1994, p. 49-53.

Research output: Contribution to journalArticle

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