Anterior cervical decompression and fusion accelerates adjacent segment degeneration: Comparison with asymptomatic volunteers in a ten-year magnetic resonance imaging follow-up study

Morio Matsumoto, Eijiro Okada, Daisuke Ichihara, Koota Watanabe, Kazuhiro Chiba, Yoshiaki Toyama, Hirokazu Fujiwara, Suketaka Momoshima, Yuji Nishiwaki, Akio Iwanami, Takeshi Ikegami, Takeshi Takahata, Takeshi Hashimoto

Research output: Contribution to journalArticle

114 Citations (Scopus)

Abstract

Study Design. Prospective 10-year follow-up magnetic resonance imaging (MRI) study of patients who underwent anterior cervical decompression and fusion (ACDF) and healthy control subjects. Objective. To clarify the incidence of adjacent segment degeneration during 10 years after ACDF. Summary of Background Data. There have been few studies which investigated incidence of progression of degenerative changes at adjacent segments in patients treated by ACDF comparing with healthy subjects. Methods. Sixty-four patients who underwent ACDF (48 males, 16 females, mean age 47.3 years, mean follow-up 12.1 year) and 201 asymptomatic volunteers who underwent MRI in our previous study (113 males, 88 females, mean age; 41.1 year, mean follow-up; 11.7 years) were included in this study. The patients and control subjects underwent follow-up MRI in this study. Following MR findings were evaluated using a numerical grading system from C2-C3-C7-T1: (1) Decrease in signal intensity of disc (DSI), (2) Posterior disc protrusion (PDP), (3) Disc space narrowing, and (4) Foraminal stenosis. When an increase in at least one grade in any of the radiographic parameters was detected between the 2 time points, progression of disc degeneration was judged as present at the level of interest. Results. Progression of DSI was significantly more frequent in ACDF group than in control group at C4-C5, while progression of PDP was significantly more frequent in ACDF group than in control group at all levels except for C5-C6. Progression of disc space narrowing and foraminal stenosis was significantly more frequent in ACDF group at C3-C4 and at C6-C7, respectively. Conclusion. Although both ACDF patients and control subjects demonstrated progression of disc degeneration during 10 years, ACDF patients had significantly higher incidence of progression of disc degeneration at adjacent segments than control subjects, while progression of disc degeneration at adjacent segments was not always related to development of clinical symptoms.

Original languageEnglish
Pages (from-to)36-43
Number of pages8
JournalSpine
Volume35
Issue number1
DOIs
Publication statusPublished - 2010 Jan

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Decompression
Volunteers
Magnetic Resonance Imaging
Intervertebral Disc Degeneration
Incidence
Healthy Volunteers
Pathologic Constriction
Control Groups

Keywords

  • Adjacent segment degeneration
  • Anterior decompression and fusion
  • Cervical spine
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Clinical Neurology
  • Orthopedics and Sports Medicine

Cite this

Anterior cervical decompression and fusion accelerates adjacent segment degeneration : Comparison with asymptomatic volunteers in a ten-year magnetic resonance imaging follow-up study. / Matsumoto, Morio; Okada, Eijiro; Ichihara, Daisuke; Watanabe, Koota; Chiba, Kazuhiro; Toyama, Yoshiaki; Fujiwara, Hirokazu; Momoshima, Suketaka; Nishiwaki, Yuji; Iwanami, Akio; Ikegami, Takeshi; Takahata, Takeshi; Hashimoto, Takeshi.

In: Spine, Vol. 35, No. 1, 01.2010, p. 36-43.

Research output: Contribution to journalArticle

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AU - Matsumoto, Morio

AU - Okada, Eijiro

AU - Ichihara, Daisuke

AU - Watanabe, Koota

AU - Chiba, Kazuhiro

AU - Toyama, Yoshiaki

AU - Fujiwara, Hirokazu

AU - Momoshima, Suketaka

AU - Nishiwaki, Yuji

AU - Iwanami, Akio

AU - Ikegami, Takeshi

AU - Takahata, Takeshi

AU - Hashimoto, Takeshi

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