Anterior insular cortex stimulation and its effects on emotion recognition

Kazuya Motomura, Yuuri Terasawa, Atsushi Natsume, Kentaro Iijima, Lushun Chalise, Junko Sugiura, Hiroyasu Yamamoto, Kyohei Koyama, Toshihiko Wakabayashi, Satoshi Umeda

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

With the objective to investigate the role of the insula in recognizing emotion, we performed direct electrical stimulation over the anterior insular cortex during awake surgery while simultaneously delivering an emotional sensitivity task. We registered 18 consecutive patients with brain tumors associated with the insular lobe, who were undergoing tumor resection. An emotional sensitivity task was employed to measure the patients’ ability to recognize emotions from facial expressions before, during, and after awake surgery. Furthermore, we performed voxel-based lesion symptom mapping (VLSM) to identify the association between relevant brain lesions and emotion recognition. When we performed direct electrical stimulation over the anterior insular cortex during awake surgery, the results showed that the ability to recognize anger was significantly enhanced with the presence of anterior insular stimulation (p < 0.05). Comparing the performance in the emotional sensitivity task before and after surgery, the performance in the anger condition became worse (p < 0.01), but became better in the sadness condition after surgery (p < 0.01). In the case of anger recognition, lower scores in the correct response index were associated with lesions involving the left insula in the VLSM study. Direct electrical stimulation over the anterior insular cortex enhanced anger recognition in patients with insular tumors. In contrast, accuracy of anger recognition was significantly reduced, and sadness was improved, when the performance of emotional sensitivity was compared pre- and post-surgery. Our findings suggest that the insular cortex is involved in changes in emotion recognition, including anger and sadness recognition by modulating arousal level that is closely connected with interoception.

Original languageEnglish
Pages (from-to)2167-2181
Number of pages15
JournalBrain Structure and Function
Volume224
Issue number6
DOIs
Publication statusPublished - 2019 Jul 1

Fingerprint

Cerebral Cortex
Anger
Emotions
Electric Stimulation
Aptitude
Facial Expression
Arousal
Brain Neoplasms
Recognition (Psychology)
Neoplasms
Brain

Keywords

  • Anger recognition
  • Anterior insular cortex
  • Awake surgery
  • Brain tumor
  • Emotion recognition

ASJC Scopus subject areas

  • Anatomy
  • Neuroscience(all)
  • Histology

Cite this

Anterior insular cortex stimulation and its effects on emotion recognition. / Motomura, Kazuya; Terasawa, Yuuri; Natsume, Atsushi; Iijima, Kentaro; Chalise, Lushun; Sugiura, Junko; Yamamoto, Hiroyasu; Koyama, Kyohei; Wakabayashi, Toshihiko; Umeda, Satoshi.

In: Brain Structure and Function, Vol. 224, No. 6, 01.07.2019, p. 2167-2181.

Research output: Contribution to journalArticle

Motomura, K, Terasawa, Y, Natsume, A, Iijima, K, Chalise, L, Sugiura, J, Yamamoto, H, Koyama, K, Wakabayashi, T & Umeda, S 2019, 'Anterior insular cortex stimulation and its effects on emotion recognition', Brain Structure and Function, vol. 224, no. 6, pp. 2167-2181. https://doi.org/10.1007/s00429-019-01895-9
Motomura, Kazuya ; Terasawa, Yuuri ; Natsume, Atsushi ; Iijima, Kentaro ; Chalise, Lushun ; Sugiura, Junko ; Yamamoto, Hiroyasu ; Koyama, Kyohei ; Wakabayashi, Toshihiko ; Umeda, Satoshi. / Anterior insular cortex stimulation and its effects on emotion recognition. In: Brain Structure and Function. 2019 ; Vol. 224, No. 6. pp. 2167-2181.
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