Anthraquinone derivatives as a new family of protein photocleavers

Akane Suzuki, Masashi Hasegawa, Maiko Ishii, Shuichi Matsumura, Kazunobu Toshima

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Certain anthraquinones, which are present in many biologically important natural products, effectively and randomly cleaved proteins (BSA or Lyso) during photoirradiation using a long wavelength UV light without any further additives. It was also found that this ability could be improved by the attachment of a suitable substituent into the anthraquinone core skeleton.

Original languageEnglish
Pages (from-to)4624-4627
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number20
DOIs
Publication statusPublished - 2005 Oct 15

Keywords

  • Anthraquinone
  • Cleavage
  • Hybrid
  • Photoirradiation
  • Protein

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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