Anthraquinone derivatives as a new family of protein photocleavers

Akane Suzuki; Masashi Hasegawa; Maiko Ishii; Shuichi Matsumura; Kazunobu Toshima

doi:10.1016/j.bmcl.2005.05.137

Anthraquinone derivatives as a new family of protein photocleavers

Akane Suzuki, Masashi Hasegawa, Maiko Ishii, Shuichi Matsumura, Kazunobu Toshima

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

Certain anthraquinones, which are present in many biologically important natural products, effectively and randomly cleaved proteins (BSA or Lyso) during photoirradiation using a long wavelength UV light without any further additives. It was also found that this ability could be improved by the attachment of a suitable substituent into the anthraquinone core skeleton.

Original language	English
Pages (from-to)	4624-4627
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	20
DOIs	https://doi.org/10.1016/j.bmcl.2005.05.137
Publication status	Published - 2005 Oct 15

Keywords

Anthraquinone
Cleavage
Hybrid
Photoirradiation
Protein

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2005.05.137

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title = "Anthraquinone derivatives as a new family of protein photocleavers",

abstract = "Certain anthraquinones, which are present in many biologically important natural products, effectively and randomly cleaved proteins (BSA or Lyso) during photoirradiation using a long wavelength UV light without any further additives. It was also found that this ability could be improved by the attachment of a suitable substituent into the anthraquinone core skeleton.",

keywords = "Anthraquinone, Cleavage, Hybrid, Photoirradiation, Protein",

author = "Akane Suzuki and Masashi Hasegawa and Maiko Ishii and Shuichi Matsumura and Kazunobu Toshima",

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AU - Suzuki, Akane

AU - Hasegawa, Masashi

AU - Ishii, Maiko

AU - Matsumura, Shuichi

AU - Toshima, Kazunobu

N1 - Funding Information: This research was partially supported by a Grant-in-Aid for the 21st Century COE Program ‘KEIO Life Conjugate Chemistry’ and a Grant-in-Aid for Scientific Research (C) from the Ministry of Education, Culture, Sports, Science and Technology, Japan.

PY - 2005/10/15

Y1 - 2005/10/15

N2 - Certain anthraquinones, which are present in many biologically important natural products, effectively and randomly cleaved proteins (BSA or Lyso) during photoirradiation using a long wavelength UV light without any further additives. It was also found that this ability could be improved by the attachment of a suitable substituent into the anthraquinone core skeleton.

AB - Certain anthraquinones, which are present in many biologically important natural products, effectively and randomly cleaved proteins (BSA or Lyso) during photoirradiation using a long wavelength UV light without any further additives. It was also found that this ability could be improved by the attachment of a suitable substituent into the anthraquinone core skeleton.

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KW - Cleavage

KW - Hybrid

KW - Photoirradiation

KW - Protein

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ER -

Anthraquinone derivatives as a new family of protein photocleavers

Abstract

Keywords

ASJC Scopus subject areas

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