Anthraquinone derivatives as a new family of protein photocleavers

Akane Suzuki, Masashi Hasegawa, Maiko Ishii, Shuichi Matsumura, Kazunobu Toshima

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Certain anthraquinones, which are present in many biologically important natural products, effectively and randomly cleaved proteins (BSA or Lyso) during photoirradiation using a long wavelength UV light without any further additives. It was also found that this ability could be improved by the attachment of a suitable substituent into the anthraquinone core skeleton.

Original languageEnglish
Pages (from-to)4624-4627
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number20
DOIs
Publication statusPublished - 2005 Oct 15

Fingerprint

Anthraquinones
Ultraviolet Rays
Biological Products
Skeleton
Ultraviolet radiation
Proteins
Wavelength

Keywords

  • Anthraquinone
  • Cleavage
  • Hybrid
  • Photoirradiation
  • Protein

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Anthraquinone derivatives as a new family of protein photocleavers. / Suzuki, Akane; Hasegawa, Masashi; Ishii, Maiko; Matsumura, Shuichi; Toshima, Kazunobu.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 15, No. 20, 15.10.2005, p. 4624-4627.

Research output: Contribution to journalArticle

Suzuki, Akane ; Hasegawa, Masashi ; Ishii, Maiko ; Matsumura, Shuichi ; Toshima, Kazunobu. / Anthraquinone derivatives as a new family of protein photocleavers. In: Bioorganic and Medicinal Chemistry Letters. 2005 ; Vol. 15, No. 20. pp. 4624-4627.
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