Anti-cytokine biological therapy in RA

Research output: Contribution to journalArticle

Abstract

Rheumatoid arthritis (RA) is characterized by persistent synovial inflammation, resulting in estruction of joints. It has been demonstrated that the pro-inflammatory cytokines play a pivotal d role in the pathogenesis of RA, raising a hypothesis that the blockade of the cytokine cascade may provide a new therapeutic modalities in the disease. Biological agents inhibiting the function of inflammatory cytokines thus have been developed. Chimeric monoclonal antibody to TNFα(infliximab), full human antibody to TNFα (adalirnumab), TNF receptor 2-IgG fusion protein (etanercept), and IL-1 ra (anakinra) are new approved for RA in the states. In 2003, infliximab has just approved for RA in Japan, and we are now facing with the biological era. In this paper, the recent progress of anti-cytokine biological agents is reviewed.

Original languageEnglish
Pages (from-to)95-102
Number of pages8
JournalDrug Delivery System
Volume19
Issue number2
DOIs
Publication statusPublished - 2004
Externally publishedYes

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Keywords

  • IL-1
  • IL-6
  • TNF

ASJC Scopus subject areas

  • Pharmaceutical Science

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