Anti-idiotypic antibodies in a patient with monoclonal rheumatoid factor after pneumococcal bacteremia

T. Abe, Tsutomu Takeuchi, M. Kiyotaki, J. Koide, O. Hosono, M. Homma, T. Otake, S. Kano

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Abstract

A 51-yr-old Japanese female patient with monoclonal IgM gammopathy with rheumatoid factor activity was admitted because of pneumococcal bacteremia. About 2 wk after admission, her rheumatoid factor activity became undetectable by RAHA test and radioimmunoassay, subsequent to the initial marked elevation. The suppressive capacity of the patient's IgG fraction on the rheumatoid activity of her monoclonal IgM on January 11 was determined. The IgG fraction obtained on February 22 blocked the binding of the rheumatoid factor to rabbit IgG. The suppressive activity in the IgG fraction of February 22 was shown to be localized within the F(ab')2 fragment. Furthermore, the specificity of the suppressive serum factor was shown by the inability to block the binding of SRBC coupled with diazotized phosphorylcholine to anti-pneumococcal antibody. Thus, the marked reduction of rheumatoid factor activity was considered to result from anti-idiotypic antibody transiently appearing in her serum after pneumococcal bacteremia.

Original languageEnglish
Pages (from-to)2381-2385
Number of pages5
JournalJournal of Immunology
Volume132
Issue number5
Publication statusPublished - 1984

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Rheumatoid Factor
Bacteremia
Anti-Idiotypic Antibodies
Immunoglobulin G
Immunoglobulin M
Paraproteinemias
Phosphorylcholine
Serum
Radioimmunoassay
Rabbits

ASJC Scopus subject areas

  • Immunology

Cite this

Abe, T., Takeuchi, T., Kiyotaki, M., Koide, J., Hosono, O., Homma, M., ... Kano, S. (1984). Anti-idiotypic antibodies in a patient with monoclonal rheumatoid factor after pneumococcal bacteremia. Journal of Immunology, 132(5), 2381-2385.

Anti-idiotypic antibodies in a patient with monoclonal rheumatoid factor after pneumococcal bacteremia. / Abe, T.; Takeuchi, Tsutomu; Kiyotaki, M.; Koide, J.; Hosono, O.; Homma, M.; Otake, T.; Kano, S.

In: Journal of Immunology, Vol. 132, No. 5, 1984, p. 2381-2385.

Research output: Contribution to journalArticle

Abe, T, Takeuchi, T, Kiyotaki, M, Koide, J, Hosono, O, Homma, M, Otake, T & Kano, S 1984, 'Anti-idiotypic antibodies in a patient with monoclonal rheumatoid factor after pneumococcal bacteremia', Journal of Immunology, vol. 132, no. 5, pp. 2381-2385.
Abe, T. ; Takeuchi, Tsutomu ; Kiyotaki, M. ; Koide, J. ; Hosono, O. ; Homma, M. ; Otake, T. ; Kano, S. / Anti-idiotypic antibodies in a patient with monoclonal rheumatoid factor after pneumococcal bacteremia. In: Journal of Immunology. 1984 ; Vol. 132, No. 5. pp. 2381-2385.
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AU - Abe, T.

AU - Takeuchi, Tsutomu

AU - Kiyotaki, M.

AU - Koide, J.

AU - Hosono, O.

AU - Homma, M.

AU - Otake, T.

AU - Kano, S.

PY - 1984

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AB - A 51-yr-old Japanese female patient with monoclonal IgM gammopathy with rheumatoid factor activity was admitted because of pneumococcal bacteremia. About 2 wk after admission, her rheumatoid factor activity became undetectable by RAHA test and radioimmunoassay, subsequent to the initial marked elevation. The suppressive capacity of the patient's IgG fraction on the rheumatoid activity of her monoclonal IgM on January 11 was determined. The IgG fraction obtained on February 22 blocked the binding of the rheumatoid factor to rabbit IgG. The suppressive activity in the IgG fraction of February 22 was shown to be localized within the F(ab')2 fragment. Furthermore, the specificity of the suppressive serum factor was shown by the inability to block the binding of SRBC coupled with diazotized phosphorylcholine to anti-pneumococcal antibody. Thus, the marked reduction of rheumatoid factor activity was considered to result from anti-idiotypic antibody transiently appearing in her serum after pneumococcal bacteremia.

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