Anti-inflammatory effect of theophylline in rats and its involvement of the glucocorticoid-glucocorticoid receptor system

Shigekazu Watanabe, Jun Yamakami, Masao Tsuchiya, Tomoko Terajima, Junko Kizu, Seiji Hori

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Although theophylline has been suggested to have an anti-inflammatory effect, there have been few reports to show the in vivo effect and the mechanism of anti-inflammatory activity of theophylline experimentally. To reveal the anti-inflammatory activity of theophylline, we studied the effect of theophylline and its metabolites on carrageenan-induced edema in rat foot pad. Subcutaneous injection of theophylline (5-100 mg/kg) inhibited carrageenan-induced edema dose-dependently. Theophylline metabolites, that is, 1-methylxanthine, 3-methylxanthine, 1-methyluric acid, and 1,3-dimethyluric acid (equimolar dose to 50 mg/kg of theophylline), did not inhibit the edema significantly. The inhibitory effect of theophylline on carrageenan-induced edema disappeared by pretreatment with aminoglutethimide, an inhibitor of glucocorticoid synthesis and with mefepristone, an antagonist of the glucocorticoid receptor. These results suggest that theophylline itself has anti-inflammatory activity and the glucocorticoid-glucocorticoid receptor system is involved in the anti-inflammatory activity of theophylline.

Original languageEnglish
Pages (from-to)566-570
Number of pages5
JournalJournal of Pharmacological Sciences
Volume106
Issue number4
DOIs
Publication statusPublished - 2008

Fingerprint

Glucocorticoid Receptors
Theophylline
Glucocorticoids
Anti-Inflammatory Agents
Carrageenan
Edema
Aminoglutethimide
Subcutaneous Injections
Foot

Keywords

  • Anti-inflammation
  • Carrageenan
  • Glucocorticoid
  • Theophylline

ASJC Scopus subject areas

  • Pharmacology

Cite this

Anti-inflammatory effect of theophylline in rats and its involvement of the glucocorticoid-glucocorticoid receptor system. / Watanabe, Shigekazu; Yamakami, Jun; Tsuchiya, Masao; Terajima, Tomoko; Kizu, Junko; Hori, Seiji.

In: Journal of Pharmacological Sciences, Vol. 106, No. 4, 2008, p. 566-570.

Research output: Contribution to journalArticle

Watanabe, Shigekazu ; Yamakami, Jun ; Tsuchiya, Masao ; Terajima, Tomoko ; Kizu, Junko ; Hori, Seiji. / Anti-inflammatory effect of theophylline in rats and its involvement of the glucocorticoid-glucocorticoid receptor system. In: Journal of Pharmacological Sciences. 2008 ; Vol. 106, No. 4. pp. 566-570.
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