Anti-obese action of raspberry ketone

Chie Morimoto, Yurie Satoh, Mariko Chikuma, Shintaro Inoue, Takahiro Tsujita, Hiromichi Okuda

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Raspberry ketone (4-(4-hydroxyphenyl) butan-2-one; RK) is a major aromatic compound of red raspberry (Rubus idaeus). The structure of RK is similar to the structures of capsaicin and synephrine, compounds known to exert anti-obese actions and alter the lipid metabolism. The present study was performed to clarify whether RK helps prevent obesity and activate lipid metabolism in rodents. To test the effect on obesity, our group designed the following in vivo experiments: 1) mice were fed a high-fat diet including 0.5, 1, or 2% of RK for 10 weeks; 2) mice were given a high-fat diet for 6 weeks and subsequently fed the same high-fat diet containing1% RK for the next 5 weeks. RK prevented the high-fat-diet-induced elevations in body weight and the weights of the liver and visceral adipose tissues (epididymal, retroperitoneal, and mesenteric). RK also decreased these weights and hepatic triacylglycerol content after they had been increased by a high-fat diet. RK significantly increased norepinephrine-induced lipolysis associated with the translocation of hormone-sensitive lipase from the cytosol to lipid droplets in rat epididymal fat cells. In conclusion, RK prevents and improves obesity and fatty liver. These effects appear to stem from the action of RK in altering the lipid metabolism, or more specifically, in increasing norepinephrine-induced lipolysis in white adipocytes.

Original languageEnglish
Pages (from-to)194-204
Number of pages11
JournalLife Sciences
Volume77
Issue number2
DOIs
Publication statusPublished - 2005 May 27
Externally publishedYes

Fingerprint

High Fat Diet
Nutrition
Fats
Lipid Metabolism
Obesity
Lipolysis
Norepinephrine
Synephrine
Liver
White Adipocytes
Sterol Esterase
Weights and Measures
Intra-Abdominal Fat
Capsaicin
Fatty Liver
Adipocytes
Aromatic compounds
Cytosol
Rodentia
Triglycerides

Keywords

  • Anti-obesity
  • High-fat diet
  • Lipolysis
  • Raspberry ketone
  • White adipocyte

ASJC Scopus subject areas

  • Pharmacology

Cite this

Morimoto, C., Satoh, Y., Chikuma, M., Inoue, S., Tsujita, T., & Okuda, H. (2005). Anti-obese action of raspberry ketone. Life Sciences, 77(2), 194-204. https://doi.org/10.1016/j.lfs.2004.12.029

Anti-obese action of raspberry ketone. / Morimoto, Chie; Satoh, Yurie; Chikuma, Mariko; Inoue, Shintaro; Tsujita, Takahiro; Okuda, Hiromichi.

In: Life Sciences, Vol. 77, No. 2, 27.05.2005, p. 194-204.

Research output: Contribution to journalArticle

Morimoto, C, Satoh, Y, Chikuma, M, Inoue, S, Tsujita, T & Okuda, H 2005, 'Anti-obese action of raspberry ketone', Life Sciences, vol. 77, no. 2, pp. 194-204. https://doi.org/10.1016/j.lfs.2004.12.029
Morimoto C, Satoh Y, Chikuma M, Inoue S, Tsujita T, Okuda H. Anti-obese action of raspberry ketone. Life Sciences. 2005 May 27;77(2):194-204. https://doi.org/10.1016/j.lfs.2004.12.029
Morimoto, Chie ; Satoh, Yurie ; Chikuma, Mariko ; Inoue, Shintaro ; Tsujita, Takahiro ; Okuda, Hiromichi. / Anti-obese action of raspberry ketone. In: Life Sciences. 2005 ; Vol. 77, No. 2. pp. 194-204.
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