Anti-thrombogenicity by layer-by-layer: Self-assembled polyelectrolyte film

Seimei Shiratori, Tomomi Matsuda

Research output: Contribution to journalConference article

Abstract

Anti-thrombogenic films with high durability were fabricated in a wet process. Anti-thrombogenicity was achieved with polyelectrolyte multilayer thin film prepared from poly(vinyl alcohol)-poly(acrylic acid)(PVA-PAA) blends, deposited in alternate layers with poly(allylamine hydrochloride) (PAH). Film durability, assessed by abrasion resistance and water resistance, was enhanced by forming crosslinks via amide bonds induced by heat treatment of the film. The film was found to be resistant to protein adsorption, as measured by the amount of fibrinogen adsorbed from an aqueous solution. Anti-thrombogenic efficacy was assessed in ex vivo experiments by the ability of stainless steel mesh, coated with the polyelectrolyte and inserted into a pig blood vessel, to inhibit thrombus formation. Mesh coated with the polyelectrolyte did not reduce blood flow over a period of 15 minutes, whereas with uncoated mesh blood flow stopped within 6 minutes because of blood vessel blockage by thrombus formation.

Original languageEnglish
Article number02003
JournalMATEC Web of Conferences
Volume4
DOIs
Publication statusPublished - 2013 Jan 1
Event14th International Conference on Organized Molecular Films, ICOMF 2013 - Paris, France
Duration: 2013 Jul 102013 Jul 13

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Engineering(all)

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