Anti-TNF biological agents in rheumatoid arthritis and other inflammatory diseases

Tsutomu Takeuchi, Kouichi Amano, Hideto Kameda, Toru Abe

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)


It is now evident that biological agents targeting on the tumor necrosis factor (TNF) have not only induce a substantial clinical response, but also inhibit the structural damage in patients with Rheumatoid Arthritis (RA). Upon the great success of anti-TNF biologicals as the therapeutic modalities of choice in the treatment of inflammatory disorders of unknown etiology, the details of TNF, and anti-TNF biological agents are extensively reviewed, particularly, focusing on those used against RA. So far, nearly one million patients are expected to expose to these agents worldwide. In Japan, chimeric monoclonal antibody to TNFα, infliximab has been approved for Crohn's disease in 2002, RA in 2003, and TNF receptor 2-IgG Fc fusion protein, etanercept had just approved for RA in 2005. Full human anti-TNFa monoclonal antibody, adalimumab is now under clinical trials. Safety profiles of these agents, based on the exposure to one hundred million patients for up to ten years, are summarized. While the experiences using biological agents in Japan are rather limited, the unique circumstances in Asian countries should been taken into account. In this respect, the issues around the anti-TNF biologicals in Japan are finally discussed.

Original languageEnglish
Pages (from-to)191-202
Number of pages12
JournalAllergology International
Issue number2
Publication statusPublished - 2005 Jun
Externally publishedYes


  • Monoclonal antibody
  • RA
  • Receptor antagonist
  • TNF

ASJC Scopus subject areas

  • Immunology and Allergy


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