Anti-voltage-gated potassium channel Kv1.4 antibodies in myasthenia gravis

Fredrik Romi, Shigeaki Suzuki, Norihiro Suzuki, Axel Petzold, Gordon T. Plant, Nils Erik Gilhus

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Myasthenia gravis (MG) is an autoimmune disease characterized by skeletal muscle weakness mainly caused by acetylcholine receptor antibodies. MG can be divided into generalized and ocular, and into early-onset (<50 years of age) and late-onset (≥50 years of age). Anti-Kv1.4 antibodies targeting a-subunits (Kv1.4) of the voltagegated potassium K+ channel occurs frequently among patients with severe MG, accounting for 18% of a Japanese MGpopulation. The aim of this study was to characterize the clinical features and serological associations of anti-Kv1.4 antibodies in a Caucasian MG population with mild and localized MG. Serum samples from 129 Caucasian MG patients with mainly ocular symptoms were tested for the presence of anti-Kv1.4 antibodies and compared to clinical and serological parameters. There were 22 (17%) anti-Kv1.4 antibody-positive patients, most of them women with lateonset MG, and all of themwith mild MG. This contrasts to the Japanese anti-Kv1.4 antibody-positive patients who suffered from severe MG with bulbar symptoms, myasthenic crisis, thymoma, myocarditis and prolonged QT time on electrocardiography, despite equal anti-Kv1.4 antibody occurrence in both populations. No other clinical or serological parameters influenced anti-Kv1.4 antibody occurrence.

Original languageEnglish
Pages (from-to)1312-1316
Number of pages5
JournalJournal of Neurology
Volume259
Issue number7
DOIs
Publication statusPublished - 2012 Jul

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Voltage-Gated Potassium Channels
Myasthenia Gravis
Anti-Idiotypic Antibodies
Antibodies
Muscle Weakness
Thymoma
Potassium Channels
Myocarditis
Cholinergic Receptors
Age of Onset
Population
Autoimmune Diseases
Electrocardiography
Skeletal Muscle

Keywords

  • Anti-Kv1.4 antibodies
  • Myasthenia gravis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Anti-voltage-gated potassium channel Kv1.4 antibodies in myasthenia gravis. / Romi, Fredrik; Suzuki, Shigeaki; Suzuki, Norihiro; Petzold, Axel; Plant, Gordon T.; Gilhus, Nils Erik.

In: Journal of Neurology, Vol. 259, No. 7, 07.2012, p. 1312-1316.

Research output: Contribution to journalArticle

Romi, F, Suzuki, S, Suzuki, N, Petzold, A, Plant, GT & Gilhus, NE 2012, 'Anti-voltage-gated potassium channel Kv1.4 antibodies in myasthenia gravis', Journal of Neurology, vol. 259, no. 7, pp. 1312-1316. https://doi.org/10.1007/s00415-011-6344-y
Romi, Fredrik ; Suzuki, Shigeaki ; Suzuki, Norihiro ; Petzold, Axel ; Plant, Gordon T. ; Gilhus, Nils Erik. / Anti-voltage-gated potassium channel Kv1.4 antibodies in myasthenia gravis. In: Journal of Neurology. 2012 ; Vol. 259, No. 7. pp. 1312-1316.
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