Antialbuminuric actions of calcilytics in the remnant kidney

Tsuneo Takenaka, Tsutomu Inoue, Takashi Miyazaki, Akira Nishiyama, Naohito Ishii, Matsuhiko Hayashi, Hiromichi Suzuki

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Hyperphosphatemia accelerates the progression of chronic kidney diseases. In the present study, the effects of ronacaleret, a calcilytic agent, on renal injury were assessed in the following four groups of rats: 5/6-nephrectomized Wistar rats as a control (C group), rats treated with ronacaleret (3 mg·kg<sup>-1</sup>·day<sup>-1</sup>; R group), rats treated with calcitriol (30 ng·kg<sup>-1</sup>·day<sup>-1</sup>; V group), and rats treated with both ronacaleret and calcitriol (R + V group). Three months later, rats were euthanized under anesthesia, and the remnant kidneys were harvested for analysis. Albuminuria was lower in the R and V groups than in the C group (P < 0.05). Creatinine clearance was elevated in the R and V groups compared with the C group (P < 0.05). Serum Ca<sup>2+</sup> and renal ANG II were higher in the R + V group than in the C group (P < 0.05 for each), and serum phosphate was reduced in the R group compared with the C group (P < 0.05). Fibroblast growth factor-23 was lower in the R group and higher in the V and R + V groups than in the C group. However, parathyroid hormone did not differ significantly among the four groups. Renal klotho expression was elevated in the R and V groups compared with the C group (P < 0.05). The present data indicate that ronacaleret preserves klotho expression and renal function with reductions in serum phosphate and albuminuria in 5/6-nephrectomized rats. Our findings demonstrate that vitamin D prevents declines in klotho expression and renal function, suppressing albuminuria.

Original languageEnglish
Pages (from-to)F216-F226
JournalAmerican Journal of Physiology - Renal Physiology
Volume309
Issue number3
DOIs
Publication statusPublished - 2015 Aug 5

Keywords

  • Calcium-sensing receptor
  • Klotho
  • Phosphate
  • Transient receptor potential channel 6
  • Vitamin D

ASJC Scopus subject areas

  • Physiology
  • Urology

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  • Cite this

    Takenaka, T., Inoue, T., Miyazaki, T., Nishiyama, A., Ishii, N., Hayashi, M., & Suzuki, H. (2015). Antialbuminuric actions of calcilytics in the remnant kidney. American Journal of Physiology - Renal Physiology, 309(3), F216-F226. https://doi.org/10.1152/ajprenal.00003.2015