Antibacterial and antiproliferative activity of cationic fullerene derivatives

Tadahiko Mashino, Dai Nishikawa, Kyoko Takahashi, Noriko Usui, Takao Yamori, Masako Seki, Toyoshige Endo, Masataka Mochizuki

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

We examined the antibacterial and antiproliferative activities of alkylated C60-bis(N,N-dimethylpyrrolidinium iodide) derivatives. The fullerene derivatives inhibited bacteria and cancer cell growth effectively. However, the fullerene derivatives with a long alkyl chain did not show antibacterial activity.

Original languageEnglish
Pages (from-to)4395-4397
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number24
DOIs
Publication statusPublished - 2003 Dec 15

Fingerprint

Fullerenes
Derivatives
Cell growth
Bacteria
Growth
Neoplasms
C60-bis(N,N-dimethylpyrrolidinium)

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Antibacterial and antiproliferative activity of cationic fullerene derivatives. / Mashino, Tadahiko; Nishikawa, Dai; Takahashi, Kyoko; Usui, Noriko; Yamori, Takao; Seki, Masako; Endo, Toyoshige; Mochizuki, Masataka.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 13, No. 24, 15.12.2003, p. 4395-4397.

Research output: Contribution to journalArticle

Mashino, Tadahiko ; Nishikawa, Dai ; Takahashi, Kyoko ; Usui, Noriko ; Yamori, Takao ; Seki, Masako ; Endo, Toyoshige ; Mochizuki, Masataka. / Antibacterial and antiproliferative activity of cationic fullerene derivatives. In: Bioorganic and Medicinal Chemistry Letters. 2003 ; Vol. 13, No. 24. pp. 4395-4397.
@article{ba0dbcf90349418d957dc6a0cb639867,
title = "Antibacterial and antiproliferative activity of cationic fullerene derivatives",
abstract = "We examined the antibacterial and antiproliferative activities of alkylated C60-bis(N,N-dimethylpyrrolidinium iodide) derivatives. The fullerene derivatives inhibited bacteria and cancer cell growth effectively. However, the fullerene derivatives with a long alkyl chain did not show antibacterial activity.",
author = "Tadahiko Mashino and Dai Nishikawa and Kyoko Takahashi and Noriko Usui and Takao Yamori and Masako Seki and Toyoshige Endo and Masataka Mochizuki",
year = "2003",
month = "12",
day = "15",
doi = "10.1016/j.bmcl.2003.09.040",
language = "English",
volume = "13",
pages = "4395--4397",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "24",

}

TY - JOUR

T1 - Antibacterial and antiproliferative activity of cationic fullerene derivatives

AU - Mashino, Tadahiko

AU - Nishikawa, Dai

AU - Takahashi, Kyoko

AU - Usui, Noriko

AU - Yamori, Takao

AU - Seki, Masako

AU - Endo, Toyoshige

AU - Mochizuki, Masataka

PY - 2003/12/15

Y1 - 2003/12/15

N2 - We examined the antibacterial and antiproliferative activities of alkylated C60-bis(N,N-dimethylpyrrolidinium iodide) derivatives. The fullerene derivatives inhibited bacteria and cancer cell growth effectively. However, the fullerene derivatives with a long alkyl chain did not show antibacterial activity.

AB - We examined the antibacterial and antiproliferative activities of alkylated C60-bis(N,N-dimethylpyrrolidinium iodide) derivatives. The fullerene derivatives inhibited bacteria and cancer cell growth effectively. However, the fullerene derivatives with a long alkyl chain did not show antibacterial activity.

UR - http://www.scopus.com/inward/record.url?scp=0344496011&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344496011&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2003.09.040

DO - 10.1016/j.bmcl.2003.09.040

M3 - Article

VL - 13

SP - 4395

EP - 4397

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 24

ER -