Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis

Peter Zanvit, Joanne E. Konkel, Xue Jiao, Shimpei Kasagi, Dunfang Zhang, Ruiqing Wu, Cheryl Chia, Nadim J. Ajami, Daniel P. Smith, Joseph F. Petrosino, Brittany Abbatiello, Hiroko Nakatsukasa, Qianming Chen, Yasmine Belkaid, Zi Jiang Chen, Wanjun Chen

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Psoriasis is an inflammatory skin disease affecting a 1/42% of the worlda € s population, but the aetiology remains incompletely understood. Recently, microbiota have been shown to differentially regulate the development of autoimmune diseases, but their influence on psoriasis is incompletely understood. We show here that adult mice treated with antibiotics that target Gram-negative and Gram-positive bacteria develop ameliorated psoriasiform dermatitis induced by imiquimod, with decreased pro-inflammatory IL-17- and IL-22-producing T cells. Surprisingly, mice treated neonatally with these antibiotics develop exacerbated psoriasis induced by imiquimod or recombinant IL-23 injection when challenged as adults, with increased IL-22-producing I 3I + T cells. 16S rRNA gene compositional analysis reveals that neonatal antibiotic-treatment dysregulates gut and skin microbiota in adults, which is associated with increased susceptibility to experimental psoriasis. This link between neonatal antibiotic-mediated imbalance in microbiota and development of experimental psoriasis provides precedence for further investigation of its specific aetiology as it relates to human psoriasis.

Original languageEnglish
Article number8424
JournalNature Communications
Volume6
DOIs
Publication statusPublished - 2015 Sep 29
Externally publishedYes

Fingerprint

antibiotics
Psoriasis
imiquimod
Anti-Bacterial Agents
etiology
magnetic permeability
T-cells
mice
Skin
dermatitis
Microbiota
Dermatitis
Interleukin-23
Interleukin-17
genes
bacteria
T-Lymphocytes
Bacteria
Genes
Gram-Positive Bacteria

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Zanvit, P., Konkel, J. E., Jiao, X., Kasagi, S., Zhang, D., Wu, R., ... Chen, W. (2015). Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis. Nature Communications, 6, [8424]. https://doi.org/10.1038/ncomms9424

Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis. / Zanvit, Peter; Konkel, Joanne E.; Jiao, Xue; Kasagi, Shimpei; Zhang, Dunfang; Wu, Ruiqing; Chia, Cheryl; Ajami, Nadim J.; Smith, Daniel P.; Petrosino, Joseph F.; Abbatiello, Brittany; Nakatsukasa, Hiroko; Chen, Qianming; Belkaid, Yasmine; Chen, Zi Jiang; Chen, Wanjun.

In: Nature Communications, Vol. 6, 8424, 29.09.2015.

Research output: Contribution to journalArticle

Zanvit, P, Konkel, JE, Jiao, X, Kasagi, S, Zhang, D, Wu, R, Chia, C, Ajami, NJ, Smith, DP, Petrosino, JF, Abbatiello, B, Nakatsukasa, H, Chen, Q, Belkaid, Y, Chen, ZJ & Chen, W 2015, 'Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis', Nature Communications, vol. 6, 8424. https://doi.org/10.1038/ncomms9424
Zanvit, Peter ; Konkel, Joanne E. ; Jiao, Xue ; Kasagi, Shimpei ; Zhang, Dunfang ; Wu, Ruiqing ; Chia, Cheryl ; Ajami, Nadim J. ; Smith, Daniel P. ; Petrosino, Joseph F. ; Abbatiello, Brittany ; Nakatsukasa, Hiroko ; Chen, Qianming ; Belkaid, Yasmine ; Chen, Zi Jiang ; Chen, Wanjun. / Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis. In: Nature Communications. 2015 ; Vol. 6.
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