Antibody isotype responses to paramyosin, a vaccine candidate for schistosomiasis, and their correlations with resistance and fibrosis in patients infected with Schistosoma japonicum in Leyte, the Philippines

Takeshi Nara, Kyoichi Iizumi, Hiroshi Ohmae, Orlando Sy, Soichi Tsubota, Yutaka Inaba, Akiko Tsubouchi, Masanobu Tanabe, Somei Kojima, Takashi Aoki

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We examined whether antibody isotype responses to paramyosin (PM), a vaccine candidate for schistosomiasis, are associated with age-dependent resistance and pathology in liver fibrosis using human sera collected from 139 individuals infected with Schistosoma japonicum in Leyte, The Philippines. We report that IgA and IgG3 responses to PM showed a positive correlation with age and that the epitopes responsible were localized predominantly within the N-terminal half of PM. In addition, the IgG3 response to PM was associated with serum level of procollagen-III-peptide (P-III-P), an indicator of progression of liver fibrosis. These results imply that IgG3 against PM may not only provoke age-dependent resistance to S. japonicum infection but also enhance liver fibrosis. In contrast, levels of IgE to PM and to multiple PM fragments showed a negative correlation with P-III-P level. Thus, in contrast to IgG3, increases in PM-specific IgE may contribute to suppression of liver pathogenesis in schistosomiasis.

Original languageEnglish
Pages (from-to)384-391
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume76
Issue number2
Publication statusPublished - 2007 Feb

Fingerprint

Schistosoma japonicum
Tropomyosin
Philippines
Schistosomiasis
Antibody Formation
Fibrosis
Vaccines
Immunoglobulin G
Liver Cirrhosis
Procollagen
Immunoglobulin E
Peptides
Serum
Immunoglobulin A
Epitopes
Pathology
Liver

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

Cite this

Antibody isotype responses to paramyosin, a vaccine candidate for schistosomiasis, and their correlations with resistance and fibrosis in patients infected with Schistosoma japonicum in Leyte, the Philippines. / Nara, Takeshi; Iizumi, Kyoichi; Ohmae, Hiroshi; Sy, Orlando; Tsubota, Soichi; Inaba, Yutaka; Tsubouchi, Akiko; Tanabe, Masanobu; Kojima, Somei; Aoki, Takashi.

In: American Journal of Tropical Medicine and Hygiene, Vol. 76, No. 2, 02.2007, p. 384-391.

Research output: Contribution to journalArticle

Nara, Takeshi ; Iizumi, Kyoichi ; Ohmae, Hiroshi ; Sy, Orlando ; Tsubota, Soichi ; Inaba, Yutaka ; Tsubouchi, Akiko ; Tanabe, Masanobu ; Kojima, Somei ; Aoki, Takashi. / Antibody isotype responses to paramyosin, a vaccine candidate for schistosomiasis, and their correlations with resistance and fibrosis in patients infected with Schistosoma japonicum in Leyte, the Philippines. In: American Journal of Tropical Medicine and Hygiene. 2007 ; Vol. 76, No. 2. pp. 384-391.
@article{3bde95ade8764c0fb333d047ca1d0553,
title = "Antibody isotype responses to paramyosin, a vaccine candidate for schistosomiasis, and their correlations with resistance and fibrosis in patients infected with Schistosoma japonicum in Leyte, the Philippines",
abstract = "We examined whether antibody isotype responses to paramyosin (PM), a vaccine candidate for schistosomiasis, are associated with age-dependent resistance and pathology in liver fibrosis using human sera collected from 139 individuals infected with Schistosoma japonicum in Leyte, The Philippines. We report that IgA and IgG3 responses to PM showed a positive correlation with age and that the epitopes responsible were localized predominantly within the N-terminal half of PM. In addition, the IgG3 response to PM was associated with serum level of procollagen-III-peptide (P-III-P), an indicator of progression of liver fibrosis. These results imply that IgG3 against PM may not only provoke age-dependent resistance to S. japonicum infection but also enhance liver fibrosis. In contrast, levels of IgE to PM and to multiple PM fragments showed a negative correlation with P-III-P level. Thus, in contrast to IgG3, increases in PM-specific IgE may contribute to suppression of liver pathogenesis in schistosomiasis.",
author = "Takeshi Nara and Kyoichi Iizumi and Hiroshi Ohmae and Orlando Sy and Soichi Tsubota and Yutaka Inaba and Akiko Tsubouchi and Masanobu Tanabe and Somei Kojima and Takashi Aoki",
year = "2007",
month = "2",
language = "English",
volume = "76",
pages = "384--391",
journal = "American Journal of Tropical Medicine and Hygiene",
issn = "0002-9637",
publisher = "American Society of Tropical Medicine and Hygiene",
number = "2",

}

TY - JOUR

T1 - Antibody isotype responses to paramyosin, a vaccine candidate for schistosomiasis, and their correlations with resistance and fibrosis in patients infected with Schistosoma japonicum in Leyte, the Philippines

AU - Nara, Takeshi

AU - Iizumi, Kyoichi

AU - Ohmae, Hiroshi

AU - Sy, Orlando

AU - Tsubota, Soichi

AU - Inaba, Yutaka

AU - Tsubouchi, Akiko

AU - Tanabe, Masanobu

AU - Kojima, Somei

AU - Aoki, Takashi

PY - 2007/2

Y1 - 2007/2

N2 - We examined whether antibody isotype responses to paramyosin (PM), a vaccine candidate for schistosomiasis, are associated with age-dependent resistance and pathology in liver fibrosis using human sera collected from 139 individuals infected with Schistosoma japonicum in Leyte, The Philippines. We report that IgA and IgG3 responses to PM showed a positive correlation with age and that the epitopes responsible were localized predominantly within the N-terminal half of PM. In addition, the IgG3 response to PM was associated with serum level of procollagen-III-peptide (P-III-P), an indicator of progression of liver fibrosis. These results imply that IgG3 against PM may not only provoke age-dependent resistance to S. japonicum infection but also enhance liver fibrosis. In contrast, levels of IgE to PM and to multiple PM fragments showed a negative correlation with P-III-P level. Thus, in contrast to IgG3, increases in PM-specific IgE may contribute to suppression of liver pathogenesis in schistosomiasis.

AB - We examined whether antibody isotype responses to paramyosin (PM), a vaccine candidate for schistosomiasis, are associated with age-dependent resistance and pathology in liver fibrosis using human sera collected from 139 individuals infected with Schistosoma japonicum in Leyte, The Philippines. We report that IgA and IgG3 responses to PM showed a positive correlation with age and that the epitopes responsible were localized predominantly within the N-terminal half of PM. In addition, the IgG3 response to PM was associated with serum level of procollagen-III-peptide (P-III-P), an indicator of progression of liver fibrosis. These results imply that IgG3 against PM may not only provoke age-dependent resistance to S. japonicum infection but also enhance liver fibrosis. In contrast, levels of IgE to PM and to multiple PM fragments showed a negative correlation with P-III-P level. Thus, in contrast to IgG3, increases in PM-specific IgE may contribute to suppression of liver pathogenesis in schistosomiasis.

UR - http://www.scopus.com/inward/record.url?scp=34047180582&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34047180582&partnerID=8YFLogxK

M3 - Article

C2 - 17297052

AN - SCOPUS:34047180582

VL - 76

SP - 384

EP - 391

JO - American Journal of Tropical Medicine and Hygiene

JF - American Journal of Tropical Medicine and Hygiene

SN - 0002-9637

IS - 2

ER -