Antibronchospasmic, tachycardiac, and hypokalaemic effects of L-isoproterenol in guinea-pigs

Hisakazu Ohtani, K. Yamamoto, Y. Sawada, T. Iga

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The relationship between antibronchospasmic, tachycardiac, or hypokalaemic effects and plasma concentration of L-isoproterenol (ISP) hydrochloride was investigated in guinea-pigs in vivo. ISP was infused at the rate of 10, 30, 50, 100, and 300 ng kg-1 min-1. The antibronchospasmic effect was expressed as the attenuation of methacholine-induced bronchospasm. The EC50 values of ISP for antibronchospasmic and tachycardiac effects were 5.12 nM and 3.95 nM, respectively. Although they were comparable to the values reported in vitro (7.23-0.358 nM, 1.77 nM), the concentration response relationship of ISP for antibronchospasmic effect was quite steep with a slope factor of more than six. Moreover, a decrease in plasma potassium level was not clearly detected. The experimental procedure in our present study was useful for evaluating antibronchospasmic and tachycardiac effects of beta-agonists.

Original languageEnglish
Pages (from-to)745-753
Number of pages9
JournalBiopharmaceutics and Drug Disposition
Volume16
Issue number9
DOIs
Publication statusPublished - 1995
Externally publishedYes

Fingerprint

Isoproterenol
Guinea Pigs
Bronchial Spasm
Methacholine Chloride
Potassium

Keywords

  • Guinea-pigs
  • Heart rate
  • Isoproterenol
  • Methacholine chloride
  • Pharmacodynamics
  • Potassium
  • Pulmonary function

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Antibronchospasmic, tachycardiac, and hypokalaemic effects of L-isoproterenol in guinea-pigs. / Ohtani, Hisakazu; Yamamoto, K.; Sawada, Y.; Iga, T.

In: Biopharmaceutics and Drug Disposition, Vol. 16, No. 9, 1995, p. 745-753.

Research output: Contribution to journalArticle

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AU - Sawada, Y.

AU - Iga, T.

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