Anticancer activity of polyunsaturated fatty acid emulsion stabilized by hydrophobized polysaccharide

H. Fukui, K. Akiyoshi, Toshinori Sato, J. Sunamoto, S. Yamaguchi, M. Numata

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

An oil-in-water emulsion of selectively cytotoxic α-linolenic acid (ALA, C18:3ω3) was stabilized with cholesterol-bearing pullulan (CHP-55-2.1), and the in vivo anticancer effect of the O/W-emulsion was investigated. The O/W-emulsion was prepared by ultrasonication of a mixture of CHP and ALA in the presence or absence of trioctanoylglyceride (TriC8). The colloidal stability of the CHP/ALA-emulsion was largely improved by adding TriC8. Intraperitoneal injection of the CHP/ALA-emulsion effectively prolonged the survival time of C3H/He mice which received an intraperitoneal transplantation of MM46 mammary tumor cells. The growth of these tumor cells subcutaneously transplanted in C3H/He mice was also significantly suppressed without any loss of body weight when CHP/ALA/TriC8-emulsion was intravenously injected. By using this colloidally stable O/W-emulsion, it is possible to systemically administer a lipophilic liquid drug.

Original languageEnglish
Pages (from-to)305-316
Number of pages12
JournalJournal of Bioactive and Compatible Polymers
Volume8
Issue number4
Publication statusPublished - 1993 Oct
Externally publishedYes

Fingerprint

Polyunsaturated fatty acids
Polysaccharides
Emulsions
Unsaturated Fatty Acids
Inbred C3H Mouse
Tumors
Bearings (structural)
Cells
alpha-Linolenic Acid
Cholesterol
Intraperitoneal Injections
Oils
Transplantation
Body Weight
Breast Neoplasms
Acids
Water
Liquids
Growth

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Materials Chemistry
  • Polymers and Plastics

Cite this

Anticancer activity of polyunsaturated fatty acid emulsion stabilized by hydrophobized polysaccharide. / Fukui, H.; Akiyoshi, K.; Sato, Toshinori; Sunamoto, J.; Yamaguchi, S.; Numata, M.

In: Journal of Bioactive and Compatible Polymers, Vol. 8, No. 4, 10.1993, p. 305-316.

Research output: Contribution to journalArticle

Fukui, H. ; Akiyoshi, K. ; Sato, Toshinori ; Sunamoto, J. ; Yamaguchi, S. ; Numata, M. / Anticancer activity of polyunsaturated fatty acid emulsion stabilized by hydrophobized polysaccharide. In: Journal of Bioactive and Compatible Polymers. 1993 ; Vol. 8, No. 4. pp. 305-316.
@article{bec9583c92394305822b8aa6647520d8,
title = "Anticancer activity of polyunsaturated fatty acid emulsion stabilized by hydrophobized polysaccharide",
abstract = "An oil-in-water emulsion of selectively cytotoxic α-linolenic acid (ALA, C18:3ω3) was stabilized with cholesterol-bearing pullulan (CHP-55-2.1), and the in vivo anticancer effect of the O/W-emulsion was investigated. The O/W-emulsion was prepared by ultrasonication of a mixture of CHP and ALA in the presence or absence of trioctanoylglyceride (TriC8). The colloidal stability of the CHP/ALA-emulsion was largely improved by adding TriC8. Intraperitoneal injection of the CHP/ALA-emulsion effectively prolonged the survival time of C3H/He mice which received an intraperitoneal transplantation of MM46 mammary tumor cells. The growth of these tumor cells subcutaneously transplanted in C3H/He mice was also significantly suppressed without any loss of body weight when CHP/ALA/TriC8-emulsion was intravenously injected. By using this colloidally stable O/W-emulsion, it is possible to systemically administer a lipophilic liquid drug.",
author = "H. Fukui and K. Akiyoshi and Toshinori Sato and J. Sunamoto and S. Yamaguchi and M. Numata",
year = "1993",
month = "10",
language = "English",
volume = "8",
pages = "305--316",
journal = "Journal of Bioactive and Compatible Polymers",
issn = "0883-9115",
publisher = "SAGE Publications Ltd",
number = "4",

}

TY - JOUR

T1 - Anticancer activity of polyunsaturated fatty acid emulsion stabilized by hydrophobized polysaccharide

AU - Fukui, H.

AU - Akiyoshi, K.

AU - Sato, Toshinori

AU - Sunamoto, J.

AU - Yamaguchi, S.

AU - Numata, M.

PY - 1993/10

Y1 - 1993/10

N2 - An oil-in-water emulsion of selectively cytotoxic α-linolenic acid (ALA, C18:3ω3) was stabilized with cholesterol-bearing pullulan (CHP-55-2.1), and the in vivo anticancer effect of the O/W-emulsion was investigated. The O/W-emulsion was prepared by ultrasonication of a mixture of CHP and ALA in the presence or absence of trioctanoylglyceride (TriC8). The colloidal stability of the CHP/ALA-emulsion was largely improved by adding TriC8. Intraperitoneal injection of the CHP/ALA-emulsion effectively prolonged the survival time of C3H/He mice which received an intraperitoneal transplantation of MM46 mammary tumor cells. The growth of these tumor cells subcutaneously transplanted in C3H/He mice was also significantly suppressed without any loss of body weight when CHP/ALA/TriC8-emulsion was intravenously injected. By using this colloidally stable O/W-emulsion, it is possible to systemically administer a lipophilic liquid drug.

AB - An oil-in-water emulsion of selectively cytotoxic α-linolenic acid (ALA, C18:3ω3) was stabilized with cholesterol-bearing pullulan (CHP-55-2.1), and the in vivo anticancer effect of the O/W-emulsion was investigated. The O/W-emulsion was prepared by ultrasonication of a mixture of CHP and ALA in the presence or absence of trioctanoylglyceride (TriC8). The colloidal stability of the CHP/ALA-emulsion was largely improved by adding TriC8. Intraperitoneal injection of the CHP/ALA-emulsion effectively prolonged the survival time of C3H/He mice which received an intraperitoneal transplantation of MM46 mammary tumor cells. The growth of these tumor cells subcutaneously transplanted in C3H/He mice was also significantly suppressed without any loss of body weight when CHP/ALA/TriC8-emulsion was intravenously injected. By using this colloidally stable O/W-emulsion, it is possible to systemically administer a lipophilic liquid drug.

UR - http://www.scopus.com/inward/record.url?scp=0027686525&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027686525&partnerID=8YFLogxK

M3 - Article

VL - 8

SP - 305

EP - 316

JO - Journal of Bioactive and Compatible Polymers

JF - Journal of Bioactive and Compatible Polymers

SN - 0883-9115

IS - 4

ER -