Abstract
An oil-in-water emulsion of selectively cytotoxic α-linolenic acid (ALA, C18:3ω3) was stabilized with cholesterol-bearing pullulan (CHP-55-2.1), and the in vivo anticancer effect of the O/W-emulsion was investigated. The O/W-emulsion was prepared by ultrasonication of a mixture of CHP and ALA in the presence or absence of trioctanoylglyceride (TriC8). The colloidal stability of the CHP/ALA-emulsion was largely improved by adding TriC8. Intraperitoneal injection of the CHP/ALA-emulsion effectively prolonged the survival time of C3H/He mice which received an intraperitoneal transplantation of MM46 mammary tumor cells. The growth of these tumor cells subcutaneously transplanted in C3H/He mice was also significantly suppressed without any loss of body weight when CHP/ALA/TriC8-emulsion was intravenously injected. By using this colloidally stable O/W-emulsion, it is possible to systemically administer a lipophilic liquid drug.
| Original language | English |
|---|---|
| Pages (from-to) | 305-316 |
| Number of pages | 12 |
| Journal | Journal of Bioactive and Compatible Polymers |
| Volume | 8 |
| Issue number | 4 |
| Publication status | Published - 1993 Oct |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biotechnology
- Biomaterials
- Materials Chemistry
- Polymers and Plastics
Cite this
Anticancer activity of polyunsaturated fatty acid emulsion stabilized by hydrophobized polysaccharide. / Fukui, H.; Akiyoshi, K.; Sato, Toshinori; Sunamoto, J.; Yamaguchi, S.; Numata, M.
In: Journal of Bioactive and Compatible Polymers, Vol. 8, No. 4, 10.1993, p. 305-316.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anticancer activity of polyunsaturated fatty acid emulsion stabilized by hydrophobized polysaccharide
AU - Fukui, H.
AU - Akiyoshi, K.
AU - Sato, Toshinori
AU - Sunamoto, J.
AU - Yamaguchi, S.
AU - Numata, M.
PY - 1993/10
Y1 - 1993/10
N2 - An oil-in-water emulsion of selectively cytotoxic α-linolenic acid (ALA, C18:3ω3) was stabilized with cholesterol-bearing pullulan (CHP-55-2.1), and the in vivo anticancer effect of the O/W-emulsion was investigated. The O/W-emulsion was prepared by ultrasonication of a mixture of CHP and ALA in the presence or absence of trioctanoylglyceride (TriC8). The colloidal stability of the CHP/ALA-emulsion was largely improved by adding TriC8. Intraperitoneal injection of the CHP/ALA-emulsion effectively prolonged the survival time of C3H/He mice which received an intraperitoneal transplantation of MM46 mammary tumor cells. The growth of these tumor cells subcutaneously transplanted in C3H/He mice was also significantly suppressed without any loss of body weight when CHP/ALA/TriC8-emulsion was intravenously injected. By using this colloidally stable O/W-emulsion, it is possible to systemically administer a lipophilic liquid drug.
AB - An oil-in-water emulsion of selectively cytotoxic α-linolenic acid (ALA, C18:3ω3) was stabilized with cholesterol-bearing pullulan (CHP-55-2.1), and the in vivo anticancer effect of the O/W-emulsion was investigated. The O/W-emulsion was prepared by ultrasonication of a mixture of CHP and ALA in the presence or absence of trioctanoylglyceride (TriC8). The colloidal stability of the CHP/ALA-emulsion was largely improved by adding TriC8. Intraperitoneal injection of the CHP/ALA-emulsion effectively prolonged the survival time of C3H/He mice which received an intraperitoneal transplantation of MM46 mammary tumor cells. The growth of these tumor cells subcutaneously transplanted in C3H/He mice was also significantly suppressed without any loss of body weight when CHP/ALA/TriC8-emulsion was intravenously injected. By using this colloidally stable O/W-emulsion, it is possible to systemically administer a lipophilic liquid drug.
UR - http://www.scopus.com/inward/record.url?scp=0027686525&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027686525&partnerID=8YFLogxK
M3 - Article
VL - 8
SP - 305
EP - 316
JO - Journal of Bioactive and Compatible Polymers
JF - Journal of Bioactive and Compatible Polymers
SN - 0883-9115
IS - 4
ER -