Anticancer Activity of Polyunsaturated Fatty Acid Emulsion Stabilized by Hydrophobized Polysaccharide

Hiroki Fukui, Kazunari Akiyoshi, Toshinori Sato, Junzo Sunamoto, Shigehiko Yamaguchi, Mituhiro Numata

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

An oil-in-water emulsion of selectively cytotoxic ±-linolenic acid (ALA, C18:3ω3) was stabilized with cholesterol-bearing pullulan (CHP-55-2.1), and the in vivo anticancer effect of the O/W-emulsion was investigated. The O/W-emulsion was prepared by ultrasonication of a mixture of CHP and ALA in the presence or absence of trioctanoylglyceride (TriC8). The colloidal stabil ity of the CHP/ALA-emulsion was largely improved by adding TriC8. Intraperi toneal injection of the CHP/ALA-emulsion effectively prolonged the survival time of C3H/He mice which received an intraperitoneal transplantation of MM46 mammary tumor cells. The growth of these tumor cells subcutaneously transplanted in C3H/He mice was also significantly suppressed without any loss of body weight when CHP/ALA/TriC8-emulsion was intravenously injected. By using this colloidally stable O/W emulsion, it is possible to systemically ad minister a lipophilic liquid drug.

Original languageEnglish
Pages (from-to)305-316
Number of pages12
JournalJournal of Bioactive and Compatible Polymers
Volume8
Issue number4
DOIs
Publication statusPublished - 1993 Oct
Externally publishedYes

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ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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