Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum

Toru Yagura; Tomoko Motomiya; Michiho Ito; Gisho Honda; Akira Iida; Fumiyuki Kiuchi; Harukuni Tokuda; Hoyoku Nishino

doi:10.1007/s11418-007-0223-y

Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum

Toru Yagura, Tomoko Motomiya, Michiho Ito, Gisho Honda, Akira Iida, Fumiyuki Kiuchi, Harukuni Tokuda, Hoyoku Nishino

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

An ethanol extract of Helichrysum maracandicum showed antiproliferative activity against cultured cells of SENCAR mouse in an in vitro assay, and activity-guided fractionation of the extract resulted in the isolation of isosalipurposide as an active substance. Naringenin chalcone, the aglycone of isosalipurposide, also showed strong antiproliferative activity. An in vivo assay of two-stage carcinogenesis on mouse skin revealed that epidermal application of isosalipurposide resulted in delayed formation of papillomas. Western blot analysis showed that the expression of p38 mitogen-activated protein kinase was suppressed by the administration of naringenin chalcone or isosalipurposide, which might be related to the anticarcinogenic activity.

Original language	English
Pages (from-to)	174-178
Number of pages	5
Journal	Journal of Natural Medicines
Volume	62
Issue number	2
DOIs	https://doi.org/10.1007/s11418-007-0223-y
Publication status	Published - 2008 Apr 1
Externally published	Yes

Keywords

Anticarcinogenic activity
Helichrysum maracandicum
Isosalipurposide
Naringenin chalcone
Two-stage carcinogenesis

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1007/s11418-007-0223-y

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title = "Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum",

abstract = "An ethanol extract of Helichrysum maracandicum showed antiproliferative activity against cultured cells of SENCAR mouse in an in vitro assay, and activity-guided fractionation of the extract resulted in the isolation of isosalipurposide as an active substance. Naringenin chalcone, the aglycone of isosalipurposide, also showed strong antiproliferative activity. An in vivo assay of two-stage carcinogenesis on mouse skin revealed that epidermal application of isosalipurposide resulted in delayed formation of papillomas. Western blot analysis showed that the expression of p38 mitogen-activated protein kinase was suppressed by the administration of naringenin chalcone or isosalipurposide, which might be related to the anticarcinogenic activity.",

keywords = "Anticarcinogenic activity, Helichrysum maracandicum, Isosalipurposide, Naringenin chalcone, Two-stage carcinogenesis",

author = "Toru Yagura and Tomoko Motomiya and Michiho Ito and Gisho Honda and Akira Iida and Fumiyuki Kiuchi and Harukuni Tokuda and Hoyoku Nishino",

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T1 - Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum

AU - Yagura, Toru

AU - Motomiya, Tomoko

AU - Ito, Michiho

AU - Honda, Gisho

AU - Iida, Akira

AU - Kiuchi, Fumiyuki

AU - Tokuda, Harukuni

AU - Nishino, Hoyoku

PY - 2008/4/1

Y1 - 2008/4/1

N2 - An ethanol extract of Helichrysum maracandicum showed antiproliferative activity against cultured cells of SENCAR mouse in an in vitro assay, and activity-guided fractionation of the extract resulted in the isolation of isosalipurposide as an active substance. Naringenin chalcone, the aglycone of isosalipurposide, also showed strong antiproliferative activity. An in vivo assay of two-stage carcinogenesis on mouse skin revealed that epidermal application of isosalipurposide resulted in delayed formation of papillomas. Western blot analysis showed that the expression of p38 mitogen-activated protein kinase was suppressed by the administration of naringenin chalcone or isosalipurposide, which might be related to the anticarcinogenic activity.

AB - An ethanol extract of Helichrysum maracandicum showed antiproliferative activity against cultured cells of SENCAR mouse in an in vitro assay, and activity-guided fractionation of the extract resulted in the isolation of isosalipurposide as an active substance. Naringenin chalcone, the aglycone of isosalipurposide, also showed strong antiproliferative activity. An in vivo assay of two-stage carcinogenesis on mouse skin revealed that epidermal application of isosalipurposide resulted in delayed formation of papillomas. Western blot analysis showed that the expression of p38 mitogen-activated protein kinase was suppressed by the administration of naringenin chalcone or isosalipurposide, which might be related to the anticarcinogenic activity.

KW - Anticarcinogenic activity

KW - Helichrysum maracandicum

KW - Isosalipurposide

KW - Naringenin chalcone

KW - Two-stage carcinogenesis

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