Abstract
An ethanol extract of Helichrysum maracandicum showed antiproliferative activity against cultured cells of SENCAR mouse in an in vitro assay, and activity-guided fractionation of the extract resulted in the isolation of isosalipurposide as an active substance. Naringenin chalcone, the aglycone of isosalipurposide, also showed strong antiproliferative activity. An in vivo assay of two-stage carcinogenesis on mouse skin revealed that epidermal application of isosalipurposide resulted in delayed formation of papillomas. Western blot analysis showed that the expression of p38 mitogen-activated protein kinase was suppressed by the administration of naringenin chalcone or isosalipurposide, which might be related to the anticarcinogenic activity.
| Original language | English |
|---|---|
| Pages (from-to) | 174-178 |
| Number of pages | 5 |
| Journal | Journal of Natural Medicines |
| Volume | 62 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2008 Apr |
| Externally published | Yes |
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Keywords
- Anticarcinogenic activity
- Helichrysum maracandicum
- Isosalipurposide
- Naringenin chalcone
- Two-stage carcinogenesis
ASJC Scopus subject areas
- Organic Chemistry
- Complementary and alternative medicine
- Drug Discovery
- Pharmaceutical Science
Cite this
Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum. / Yagura, Toru; Motomiya, Tomoko; Ito, Michiho; Honda, Gisho; Iida, Akira; Kiuchi, Fumiyuki; Tokuda, Harukuni; Nishino, Hoyoku.
In: Journal of Natural Medicines, Vol. 62, No. 2, 04.2008, p. 174-178.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Anticarcinogenic compounds in the Uzbek medicinal plant, Helichrysum maracandicum
AU - Yagura, Toru
AU - Motomiya, Tomoko
AU - Ito, Michiho
AU - Honda, Gisho
AU - Iida, Akira
AU - Kiuchi, Fumiyuki
AU - Tokuda, Harukuni
AU - Nishino, Hoyoku
PY - 2008/4
Y1 - 2008/4
N2 - An ethanol extract of Helichrysum maracandicum showed antiproliferative activity against cultured cells of SENCAR mouse in an in vitro assay, and activity-guided fractionation of the extract resulted in the isolation of isosalipurposide as an active substance. Naringenin chalcone, the aglycone of isosalipurposide, also showed strong antiproliferative activity. An in vivo assay of two-stage carcinogenesis on mouse skin revealed that epidermal application of isosalipurposide resulted in delayed formation of papillomas. Western blot analysis showed that the expression of p38 mitogen-activated protein kinase was suppressed by the administration of naringenin chalcone or isosalipurposide, which might be related to the anticarcinogenic activity.
AB - An ethanol extract of Helichrysum maracandicum showed antiproliferative activity against cultured cells of SENCAR mouse in an in vitro assay, and activity-guided fractionation of the extract resulted in the isolation of isosalipurposide as an active substance. Naringenin chalcone, the aglycone of isosalipurposide, also showed strong antiproliferative activity. An in vivo assay of two-stage carcinogenesis on mouse skin revealed that epidermal application of isosalipurposide resulted in delayed formation of papillomas. Western blot analysis showed that the expression of p38 mitogen-activated protein kinase was suppressed by the administration of naringenin chalcone or isosalipurposide, which might be related to the anticarcinogenic activity.
KW - Anticarcinogenic activity
KW - Helichrysum maracandicum
KW - Isosalipurposide
KW - Naringenin chalcone
KW - Two-stage carcinogenesis
UR - http://www.scopus.com/inward/record.url?scp=40549101349&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40549101349&partnerID=8YFLogxK
U2 - 10.1007/s11418-007-0223-y
DO - 10.1007/s11418-007-0223-y
M3 - Article
C2 - 18404319
AN - SCOPUS:40549101349
VL - 62
SP - 174
EP - 178
JO - Journal of Natural Medicines
JF - Journal of Natural Medicines
SN - 1861-0293
IS - 2
ER -