Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme

Nahoko Uchiyama, Zakayi Kabututu, Bruno K. Kubata, Fumiyuki Kiuchi, Michiho Ito, Junko Nakajima-Shimada, Takashi Aoki, Kei Ohkubo, Shunichi Fukuzumi, Samuel K. Martin, Gisho Honda, Yoshihiro Urade

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

A novel potent trypanocidal diterpene, komaroviquinone, was reduced by Trypanosoma cruzi old yellow enzyme (TcOYE) to its semiquinone radical. The reductase activity in trypanosome lysates was completely immunoabsorbed by anti-TcOYE antibody. Since TcOYE is expressed throughout the T. cruzi life cycle, komaroviquinone is an interesting candidate for developing new antichagasic drugs.

Original languageEnglish
Pages (from-to)5123-5126
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume49
Issue number12
DOIs
Publication statusPublished - 2005 Dec
Externally publishedYes

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NADPH Dehydrogenase
Trypanosoma cruzi
Reactive Oxygen Species
Trypanosomiasis
Diterpenes
Life Cycle Stages
Oxidoreductases
komaroviquinone
Antibodies
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme. / Uchiyama, Nahoko; Kabututu, Zakayi; Kubata, Bruno K.; Kiuchi, Fumiyuki; Ito, Michiho; Nakajima-Shimada, Junko; Aoki, Takashi; Ohkubo, Kei; Fukuzumi, Shunichi; Martin, Samuel K.; Honda, Gisho; Urade, Yoshihiro.

In: Antimicrobial Agents and Chemotherapy, Vol. 49, No. 12, 12.2005, p. 5123-5126.

Research output: Contribution to journalArticle

Uchiyama, N, Kabututu, Z, Kubata, BK, Kiuchi, F, Ito, M, Nakajima-Shimada, J, Aoki, T, Ohkubo, K, Fukuzumi, S, Martin, SK, Honda, G & Urade, Y 2005, 'Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme', Antimicrobial Agents and Chemotherapy, vol. 49, no. 12, pp. 5123-5126. https://doi.org/10.1128/AAC.49.12.5123-5126.2005
Uchiyama, Nahoko ; Kabututu, Zakayi ; Kubata, Bruno K. ; Kiuchi, Fumiyuki ; Ito, Michiho ; Nakajima-Shimada, Junko ; Aoki, Takashi ; Ohkubo, Kei ; Fukuzumi, Shunichi ; Martin, Samuel K. ; Honda, Gisho ; Urade, Yoshihiro. / Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme. In: Antimicrobial Agents and Chemotherapy. 2005 ; Vol. 49, No. 12. pp. 5123-5126.
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