Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme

Nahoko Uchiyama, Zakayi Kabututu, Bruno K. Kubata, Fumiyuki Kiuchi, Michiho Ito, Junko Nakajima-Shimada, Takashi Aoki, Kei Ohkubo, Shunichi Fukuzumi, Samuel K. Martin, Gisho Honda, Yoshihiro Urade

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

A novel potent trypanocidal diterpene, komaroviquinone, was reduced by Trypanosoma cruzi old yellow enzyme (TcOYE) to its semiquinone radical. The reductase activity in trypanosome lysates was completely immunoabsorbed by anti-TcOYE antibody. Since TcOYE is expressed throughout the T. cruzi life cycle, komaroviquinone is an interesting candidate for developing new antichagasic drugs.

Original languageEnglish
Pages (from-to)5123-5126
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume49
Issue number12
DOIs
Publication statusPublished - 2005 Dec 1
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Uchiyama, N., Kabututu, Z., Kubata, B. K., Kiuchi, F., Ito, M., Nakajima-Shimada, J., Aoki, T., Ohkubo, K., Fukuzumi, S., Martin, S. K., Honda, G., & Urade, Y. (2005). Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme. Antimicrobial Agents and Chemotherapy, 49(12), 5123-5126. https://doi.org/10.1128/AAC.49.12.5123-5126.2005