Antiganglioside antibodies are associated with axonal Guillain-Barré syndrome: A Japanese-Italian collaborative study

Yukari Sekiguchi, Antonino Uncini, Nobuhiro Yuki, Sonoko Misawa, Francesca Notturno, Saiko Nasu, Kazuaki Kanai, Yu Ichi Noto, Yumi Fujimaki, Kazumoto Shibuya, Shigeki Ohmori, Yasunori Sato, Satoshi Kuwabara

Research output: Contribution to journalArticle

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Abstract

Background: Whether or not antiganglioside antibodies are related to axonal or demyelinating Guillain-Barrésyndrome (GBS) is still a matter of controversy, as detailed in previous studies conducted in Western and Asian countries. Objective: To clarify whether antiganglioside antibodies are associated with axonal dysfunction in Japanese and Italian GBS patient cohorts. Methods: Clinical and electrophysiological profiles were reviewed for 156 GBS patients collected from Japan (n=103) and Italy (n=53). Serum IgG antibodies against GM1, GM1b, GD1a and GalNAc-GD1a were measured by ELISA in the same laboratory. Electrodiagnostic criteria and results of serial electrophysiological studies were used for classification of GBS subtypes: acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). Results In both Japanese and Italian cohorts, any of the antibodies were positive in 36% of the patients, and antibody positivity had a significant association with the AMAN electrodiagnosis. Approximately 30% of Japanese and Italian antiganglioside positive patients showed the AIDP pattern at the first examination whereas sequential studies showed that most finally showed the AMAN pattern. Clinically, seropositive patients more frequently had preceding diarrhoea and pure motor neuropathy in both Japanese and Italian cohorts; vibratory sensation was normal in 97% of Japanese and in 94% of Italian seropositive patients. Conclusions: In GBS, clinical and electrophysiological features appear to be determined by antiganglioside antibodies, and the antibodies are associated with motor axonal GBS in both Japan and Italy. Classification of the GBS subtypes as a disease entity should be made, combining the results of antiganglioside assays and serial electrodiagnostic studies.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume83
Issue number1
DOIs
Publication statusPublished - 2012 Jan 1
Externally publishedYes

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Antibodies
Guillain-Barre Syndrome
Italy
Japan
Electrodiagnosis
Diarrhea
Immunoglobulin G
Enzyme-Linked Immunosorbent Assay
Serum

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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Antiganglioside antibodies are associated with axonal Guillain-Barré syndrome : A Japanese-Italian collaborative study. / Sekiguchi, Yukari; Uncini, Antonino; Yuki, Nobuhiro; Misawa, Sonoko; Notturno, Francesca; Nasu, Saiko; Kanai, Kazuaki; Noto, Yu Ichi; Fujimaki, Yumi; Shibuya, Kazumoto; Ohmori, Shigeki; Sato, Yasunori; Kuwabara, Satoshi.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 83, No. 1, 01.01.2012, p. 23-28.

Research output: Contribution to journalArticle

Sekiguchi, Y, Uncini, A, Yuki, N, Misawa, S, Notturno, F, Nasu, S, Kanai, K, Noto, YI, Fujimaki, Y, Shibuya, K, Ohmori, S, Sato, Y & Kuwabara, S 2012, 'Antiganglioside antibodies are associated with axonal Guillain-Barré syndrome: A Japanese-Italian collaborative study', Journal of Neurology, Neurosurgery and Psychiatry, vol. 83, no. 1, pp. 23-28. https://doi.org/10.1136/jnnp-2011-300309
Sekiguchi, Yukari ; Uncini, Antonino ; Yuki, Nobuhiro ; Misawa, Sonoko ; Notturno, Francesca ; Nasu, Saiko ; Kanai, Kazuaki ; Noto, Yu Ichi ; Fujimaki, Yumi ; Shibuya, Kazumoto ; Ohmori, Shigeki ; Sato, Yasunori ; Kuwabara, Satoshi. / Antiganglioside antibodies are associated with axonal Guillain-Barré syndrome : A Japanese-Italian collaborative study. In: Journal of Neurology, Neurosurgery and Psychiatry. 2012 ; Vol. 83, No. 1. pp. 23-28.
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title = "Antiganglioside antibodies are associated with axonal Guillain-Barr{\'e} syndrome: A Japanese-Italian collaborative study",
abstract = "Background: Whether or not antiganglioside antibodies are related to axonal or demyelinating Guillain-Barr{\'e}syndrome (GBS) is still a matter of controversy, as detailed in previous studies conducted in Western and Asian countries. Objective: To clarify whether antiganglioside antibodies are associated with axonal dysfunction in Japanese and Italian GBS patient cohorts. Methods: Clinical and electrophysiological profiles were reviewed for 156 GBS patients collected from Japan (n=103) and Italy (n=53). Serum IgG antibodies against GM1, GM1b, GD1a and GalNAc-GD1a were measured by ELISA in the same laboratory. Electrodiagnostic criteria and results of serial electrophysiological studies were used for classification of GBS subtypes: acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). Results In both Japanese and Italian cohorts, any of the antibodies were positive in 36{\%} of the patients, and antibody positivity had a significant association with the AMAN electrodiagnosis. Approximately 30{\%} of Japanese and Italian antiganglioside positive patients showed the AIDP pattern at the first examination whereas sequential studies showed that most finally showed the AMAN pattern. Clinically, seropositive patients more frequently had preceding diarrhoea and pure motor neuropathy in both Japanese and Italian cohorts; vibratory sensation was normal in 97{\%} of Japanese and in 94{\%} of Italian seropositive patients. Conclusions: In GBS, clinical and electrophysiological features appear to be determined by antiganglioside antibodies, and the antibodies are associated with motor axonal GBS in both Japan and Italy. Classification of the GBS subtypes as a disease entity should be made, combining the results of antiganglioside assays and serial electrodiagnostic studies.",
author = "Yukari Sekiguchi and Antonino Uncini and Nobuhiro Yuki and Sonoko Misawa and Francesca Notturno and Saiko Nasu and Kazuaki Kanai and Noto, {Yu Ichi} and Yumi Fujimaki and Kazumoto Shibuya and Shigeki Ohmori and Yasunori Sato and Satoshi Kuwabara",
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T1 - Antiganglioside antibodies are associated with axonal Guillain-Barré syndrome

T2 - A Japanese-Italian collaborative study

AU - Sekiguchi, Yukari

AU - Uncini, Antonino

AU - Yuki, Nobuhiro

AU - Misawa, Sonoko

AU - Notturno, Francesca

AU - Nasu, Saiko

AU - Kanai, Kazuaki

AU - Noto, Yu Ichi

AU - Fujimaki, Yumi

AU - Shibuya, Kazumoto

AU - Ohmori, Shigeki

AU - Sato, Yasunori

AU - Kuwabara, Satoshi

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Background: Whether or not antiganglioside antibodies are related to axonal or demyelinating Guillain-Barrésyndrome (GBS) is still a matter of controversy, as detailed in previous studies conducted in Western and Asian countries. Objective: To clarify whether antiganglioside antibodies are associated with axonal dysfunction in Japanese and Italian GBS patient cohorts. Methods: Clinical and electrophysiological profiles were reviewed for 156 GBS patients collected from Japan (n=103) and Italy (n=53). Serum IgG antibodies against GM1, GM1b, GD1a and GalNAc-GD1a were measured by ELISA in the same laboratory. Electrodiagnostic criteria and results of serial electrophysiological studies were used for classification of GBS subtypes: acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). Results In both Japanese and Italian cohorts, any of the antibodies were positive in 36% of the patients, and antibody positivity had a significant association with the AMAN electrodiagnosis. Approximately 30% of Japanese and Italian antiganglioside positive patients showed the AIDP pattern at the first examination whereas sequential studies showed that most finally showed the AMAN pattern. Clinically, seropositive patients more frequently had preceding diarrhoea and pure motor neuropathy in both Japanese and Italian cohorts; vibratory sensation was normal in 97% of Japanese and in 94% of Italian seropositive patients. Conclusions: In GBS, clinical and electrophysiological features appear to be determined by antiganglioside antibodies, and the antibodies are associated with motor axonal GBS in both Japan and Italy. Classification of the GBS subtypes as a disease entity should be made, combining the results of antiganglioside assays and serial electrodiagnostic studies.

AB - Background: Whether or not antiganglioside antibodies are related to axonal or demyelinating Guillain-Barrésyndrome (GBS) is still a matter of controversy, as detailed in previous studies conducted in Western and Asian countries. Objective: To clarify whether antiganglioside antibodies are associated with axonal dysfunction in Japanese and Italian GBS patient cohorts. Methods: Clinical and electrophysiological profiles were reviewed for 156 GBS patients collected from Japan (n=103) and Italy (n=53). Serum IgG antibodies against GM1, GM1b, GD1a and GalNAc-GD1a were measured by ELISA in the same laboratory. Electrodiagnostic criteria and results of serial electrophysiological studies were used for classification of GBS subtypes: acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). Results In both Japanese and Italian cohorts, any of the antibodies were positive in 36% of the patients, and antibody positivity had a significant association with the AMAN electrodiagnosis. Approximately 30% of Japanese and Italian antiganglioside positive patients showed the AIDP pattern at the first examination whereas sequential studies showed that most finally showed the AMAN pattern. Clinically, seropositive patients more frequently had preceding diarrhoea and pure motor neuropathy in both Japanese and Italian cohorts; vibratory sensation was normal in 97% of Japanese and in 94% of Italian seropositive patients. Conclusions: In GBS, clinical and electrophysiological features appear to be determined by antiganglioside antibodies, and the antibodies are associated with motor axonal GBS in both Japan and Italy. Classification of the GBS subtypes as a disease entity should be made, combining the results of antiganglioside assays and serial electrodiagnostic studies.

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