Antigen-specific T-cell activation in hyperplastic thymus in myasthenia gravis

Kimiaki Utsugisawa, Yuriko Nagane, Shigeaki Suzuki, Ryushi Kondoh

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In order to determine whether antigen-specific T-cell activation by dendritic cells (DCs) is accelerated in thymuses exhibiting lymphofollicular hyperplasia (TLFH) among patients with early-onset myasthenia gravis (EOMG), we investigated the expression levels of phosphorylated protein kinase C (PKC)θ and the local relationship between the presence of phosphorylated PKCθ and the homing receptor CD44 or CD83, a marker for mature DCs, in samples taken from EOMG patients with early improvement following thymectomy, in remnant thymuses from late-onset MG patients, and in non-MG control thymuses. Antigen-specific T-cell activation was markedly accelerated in TLFH from EOMG patients. Activated T cells and adjacent DCs appeared to be components of a CD44high cell population circulating from the blood to the thymus. Although there is no convincing evidence that thymectomy is of benefit in MG, in some EOMG patients with early improvement following thymectomy, blockade of CD44-associated circulation mechanisms is probably the cause for the early benefits of thymectomy and is a potential alternative to thymectomy.

Original languageEnglish
Pages (from-to)100-103
Number of pages4
JournalMuscle and Nerve
Volume36
Issue number1
DOIs
Publication statusPublished - 2007 Jul 1

Keywords

  • Dendritic cell
  • Myasthenia gravis
  • Protein kinase Cθ
  • T cell activation
  • Thymus

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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