Antihepatotoxic actions of gingerols and diarylheptanoids

Hiking Hiroshi, Kiso Yoshinobu, Kato Nobuharu, Hamada Yasumasa, Shioiri Takayuki, Aiyama Ritsuo, Itokawa Hideji, Kiuchi Fumiyuki, Sankawa Ushio

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68 Citations (Scopus)

Abstract

The antihepatotoxic effects of gingerols, shogaols, diarylheptanoids and related analogues were assessed utilizing carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. Most congeners exhibited significant actions in these assay methods. The carbon tetrachloride assay appeared to be most useful in defining structure-activity relationships. The antihepatotoxic activity of gingerols and shogaols was dependent on the length of the side chain with the [7]- and [8]-companions eliciting the strongest activity. The gingerols exerted more intense activity than the corresponding shogaols. In the diarylheptanoids, introduction of hydroxyl groupings on the phenyl rings caused increased activity; however, the effect of the positions and number of hydroxyls on activity was variable depending on the carbon skeleton.

Original languageEnglish
Pages (from-to)31-39
Number of pages9
JournalJournal of Ethnopharmacology
Volume14
Issue number1
DOIs
Publication statusPublished - 1985 Sep
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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    Hiroshi, H., Yoshinobu, K., Nobuharu, K., Yasumasa, H., Takayuki, S., Ritsuo, A., Hideji, I., Fumiyuki, K., & Ushio, S. (1985). Antihepatotoxic actions of gingerols and diarylheptanoids. Journal of Ethnopharmacology, 14(1), 31-39. https://doi.org/10.1016/0378-8741(85)90025-X