Antihypertensive action of melatonin in the spontaneously hypertensive rat

Koichiro Kawashima; Yuko Miwa; Kazuko Fujimoto; Hisayo Oohata; Hiroshi Nishino; Hiroyuki Koike

doi:10.3109/10641968709160037

Antihypertensive action of melatonin in the spontaneously hypertensive rat

Koichiro Kawashima, Yuko Miwa, Kazuko Fujimoto, Hisayo Oohata, Hiroshi Nishino, Hiroyuki Koike

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

90 Citations (Scopus)

Abstract

The effects of melatonin on blood pressure and heart rate were studied in 23-week-old male spontaneously hypertensive rats. Melatonin infused i.p. at a dose of 6 mg/rat per day for 5 days using an osmotic minipump produced a significant reduction of blood pressure and a slight but significant decrease of heart rate in the conscious and unrestrained state. These cardiovascular effects of melatonin developed gradually. Plasma renin concentration tended to decrease after melatonin treatment. These results demonstrate that melatonin has an antihypertensive action. The mechanism of the antihypertensive action of melatonin requires further study.

Original language	English
Pages (from-to)	1121-1131
Number of pages	11
Journal	Clinical and Experimental Hypertension
Volume	A9
Issue number	7
DOIs	https://doi.org/10.3109/10641968709160037
Publication status	Published - 1987

Keywords

Antihypertensive action
Heart rate
Melatonin
Plasma renin concentration
Spontaneously hypertensive rats

ASJC Scopus subject areas

Internal Medicine
Physiology

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10.3109/10641968709160037

Cite this

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title = "Antihypertensive action of melatonin in the spontaneously hypertensive rat",

abstract = "The effects of melatonin on blood pressure and heart rate were studied in 23-week-old male spontaneously hypertensive rats. Melatonin infused i.p. at a dose of 6 mg/rat per day for 5 days using an osmotic minipump produced a significant reduction of blood pressure and a slight but significant decrease of heart rate in the conscious and unrestrained state. These cardiovascular effects of melatonin developed gradually. Plasma renin concentration tended to decrease after melatonin treatment. These results demonstrate that melatonin has an antihypertensive action. The mechanism of the antihypertensive action of melatonin requires further study.",

keywords = "Antihypertensive action, Heart rate, Melatonin, Plasma renin concentration, Spontaneously hypertensive rats",

author = "Koichiro Kawashima and Yuko Miwa and Kazuko Fujimoto and Hisayo Oohata and Hiroshi Nishino and Hiroyuki Koike",

note = "Funding Information: This work was supported in part by grants from the Foundation for the Promotion of Research on Medical Resources and the Suzuken Memorial Foundation.",

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T1 - Antihypertensive action of melatonin in the spontaneously hypertensive rat

AU - Kawashima, Koichiro

AU - Miwa, Yuko

AU - Fujimoto, Kazuko

AU - Oohata, Hisayo

AU - Nishino, Hiroshi

AU - Koike, Hiroyuki

N1 - Funding Information: This work was supported in part by grants from the Foundation for the Promotion of Research on Medical Resources and the Suzuken Memorial Foundation.

PY - 1987

Y1 - 1987

N2 - The effects of melatonin on blood pressure and heart rate were studied in 23-week-old male spontaneously hypertensive rats. Melatonin infused i.p. at a dose of 6 mg/rat per day for 5 days using an osmotic minipump produced a significant reduction of blood pressure and a slight but significant decrease of heart rate in the conscious and unrestrained state. These cardiovascular effects of melatonin developed gradually. Plasma renin concentration tended to decrease after melatonin treatment. These results demonstrate that melatonin has an antihypertensive action. The mechanism of the antihypertensive action of melatonin requires further study.

AB - The effects of melatonin on blood pressure and heart rate were studied in 23-week-old male spontaneously hypertensive rats. Melatonin infused i.p. at a dose of 6 mg/rat per day for 5 days using an osmotic minipump produced a significant reduction of blood pressure and a slight but significant decrease of heart rate in the conscious and unrestrained state. These cardiovascular effects of melatonin developed gradually. Plasma renin concentration tended to decrease after melatonin treatment. These results demonstrate that melatonin has an antihypertensive action. The mechanism of the antihypertensive action of melatonin requires further study.

KW - Antihypertensive action

KW - Heart rate

KW - Melatonin

KW - Plasma renin concentration

KW - Spontaneously hypertensive rats

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Antihypertensive action of melatonin in the spontaneously hypertensive rat

Abstract

Keywords

ASJC Scopus subject areas

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