Antihypertensive effect of synthetic tetrandrine derivatives in SHR rats

Koichiro Kawashima, Terumasa Hayakawa, Oohata Hisayo, Kazuko Fujimoto, Takeshi Suzuki, Tatsunori Ogino, Zhengxiong Chen (Masao Chin)

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

1. 1. Effects of oral administration of synthetic tetrandrine (TD) derivatives (20 mg/kg per day) for 9 weeks on blood pressure, heart rate, plasma renin concentration (PRC) and vascular reactivities to pressor substances were studied in spontaneously hypertensive (SHR) rats. 2. 2. 7-O-Ethyl fangchinolin (7-O-EFC) and 7-O-isopropyl fangchinolin (7-O-IFC) produced a significant and sustained reduction in blood pressure from the first week of administration. 7-O-EFC reduced heart rate when determined under restraint conditions, but not under unanesthetized, freely moving conditions. 3. 3. TD derivatives produced no effect on PRC. 4. 4. Pressor response to phenylephrine was reduced significantly whereas the response to angiotensin II was enhanced after prolonged administration of 7-O-EFC and 7-O-IFC. 5. 5. These results demonstrate that TD derivatives are potential antihypertensive drugs, and that attenuation of the pressor response to phenylephrine may contribute at least in part to its antihypertensive effect.

Original languageEnglish
Pages (from-to)165-168
Number of pages4
JournalGeneral Pharmacology
Volume22
Issue number1
DOIs
Publication statusPublished - 1991

    Fingerprint

ASJC Scopus subject areas

  • Pharmacology

Cite this