Antimetastatic effect by Juzen-taiho-to in the liver metastasis model of colon 26-L5 carcinoma

Y. Ohnishi, H. Fujii, F. Kimura, Y. Hayakawa, R. Sakukawa, J. Murata, T. Sakamoto, K. Tazawa, M. Fujimaki, I. Saiki

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the inhibitory effect of Juzen-taiho--o in an experimental liver metastasis model, by means of inoculation of a highly liver-metastatic variant (L5) of murine colon 26 carcinoma cells into the portal vein. Oral administration of Juzen-taiho-to before tumor inoculation resulted in the dosedependent inhibition of liver tumor colonies. Oral administration of Juzen-taiho-to for 7 days before tumor inoculation led to a significant reduction in the number of metastatic colonies and liver weight even in NK-depleted mice as well as normal mice, but not in macrophage- deficient mice. This finding shows that the inhibition of metastasis by Juzen-taiho-to is associated with macrophage function.

Original languageEnglish
Pages (from-to)187-189
Number of pages3
JournalBiotherapy
Volume12
Issue number1
Publication statusPublished - 1998
Externally publishedYes

Keywords

  • Colon 26-L5
  • Juzen-taiho-to
  • Liver metastasis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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