Antimetastatic effect by vaccination of tumor cells transfected with B7- 1 (CD80) gene

Y. Ohnishi; H. Fujii; M. Inobe; F. Kimura; J. Murata; M. Murakami; T. Uede; T. Sakamoto; K. Tazawa; M. Fujimaki; I. Saiki

Antimetastatic effect by vaccination of tumor cells transfected with B7- 1 (CD80) gene

Y. Ohnishi, H. Fujii, M. Inobe, F. Kimura, J. Murata, M. Murakami, T. Uede, T. Sakamoto, K. Tazawa, M. Fujimaki, I. Saiki

Research output: Contribution to journal › Article › peer-review

Abstract

In order to induce the efficient activation of T cells followed by anti- tumor immunity, we established B7⁺ tumor cells by transfection with B7-1 (CD80) gene into B16 BL6 melanoma cells (B7^- cells) and investigated the effect of immunization with irradiated B7-transfected cells on experimental and spontaneous lung metastasis. Immunization of irradiated B7⁺ cells resulted in the remarkable reduction of lung tumor colonies as compared with B7^- parental cells. Combination of vaccination with Lentinan/IL-2 led to the augmentation of anti metastatic effect.

Original language	English
Pages (from-to)	621-622
Number of pages	2
Journal	Biotherapy
Volume	11
Issue number	5
Publication status	Published - 1997
Externally published	Yes

Keywords

B7
IL-2
Lentinan
Metastasis
Vaccination

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "In order to induce the efficient activation of T cells followed by anti- tumor immunity, we established B7+ tumor cells by transfection with B7-1 (CD80) gene into B16 BL6 melanoma cells (B7- cells) and investigated the effect of immunization with irradiated B7-transfected cells on experimental and spontaneous lung metastasis. Immunization of irradiated B7+ cells resulted in the remarkable reduction of lung tumor colonies as compared with B7- parental cells. Combination of vaccination with Lentinan/IL-2 led to the augmentation of anti metastatic effect.",

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author = "Y. Ohnishi and H. Fujii and M. Inobe and F. Kimura and J. Murata and M. Murakami and T. Uede and T. Sakamoto and K. Tazawa and M. Fujimaki and I. Saiki",

year = "1997",

language = "English",

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T1 - Antimetastatic effect by vaccination of tumor cells transfected with B7- 1 (CD80) gene

AU - Ohnishi, Y.

AU - Fujii, H.

AU - Inobe, M.

AU - Kimura, F.

AU - Murata, J.

AU - Murakami, M.

AU - Uede, T.

AU - Sakamoto, T.

AU - Tazawa, K.

AU - Fujimaki, M.

AU - Saiki, I.

PY - 1997

Y1 - 1997

N2 - In order to induce the efficient activation of T cells followed by anti- tumor immunity, we established B7+ tumor cells by transfection with B7-1 (CD80) gene into B16 BL6 melanoma cells (B7- cells) and investigated the effect of immunization with irradiated B7-transfected cells on experimental and spontaneous lung metastasis. Immunization of irradiated B7+ cells resulted in the remarkable reduction of lung tumor colonies as compared with B7- parental cells. Combination of vaccination with Lentinan/IL-2 led to the augmentation of anti metastatic effect.

AB - In order to induce the efficient activation of T cells followed by anti- tumor immunity, we established B7+ tumor cells by transfection with B7-1 (CD80) gene into B16 BL6 melanoma cells (B7- cells) and investigated the effect of immunization with irradiated B7-transfected cells on experimental and spontaneous lung metastasis. Immunization of irradiated B7+ cells resulted in the remarkable reduction of lung tumor colonies as compared with B7- parental cells. Combination of vaccination with Lentinan/IL-2 led to the augmentation of anti metastatic effect.

KW - B7

KW - IL-2

KW - Lentinan

KW - Metastasis

KW - Vaccination

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M3 - Article

AN - SCOPUS:0030905950

SN - 0914-2223

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JO - Biotherapy

JF - Biotherapy

IS - 5

ER -

Antimetastatic effect by vaccination of tumor cells transfected with B7- 1 (CD80) gene

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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