Antimicrobial susceptibility of Chlamydia pneumoniae isolates from children and their families

Teruko Komoda, Hisaichi Bannai, Toshikatsu Hagiwara, Satoshi Iwata, Hironobu Akita, Yoshitake Satou, Takao Yokota, Keisuke Sunakawa

Research output: Contribution to journalArticle

Abstract

Eighteen isolates of Chlamydia pneumoniae from ill children with bronchitis and/or pneumonia and their families were tested in terms of susceptibility to antimicrobial agents. (These strains were isolated from May 1992 to December 1995). The antibiotics used were doxycline (DOXY), erythromycin (EM), rokitamycin (RKM), azithromycin (AZM), clarithromycin (CAM), roxithromycin (RXM) and ofloxacin (OFLX). The MIC ranges of these antibiotics against the isolates wee 0.03~0.125 μg/ml except OFLX (0.5~2.5 μg/ml), and the MICs were similar to those for C. pneumoniae TW 183 and C. trachomatis serovar L2. The minimal chlamydiacidal concentration was also determined by using 10 isolates for which the concentration was about 10 times higher than the MIC. No difference was found among the isolates from the same patients.

Original languageEnglish
Pages (from-to)205-209
Number of pages5
JournalJapanese Journal of Chemotherapy
Volume46
Issue number6
Publication statusPublished - 1998 Aug 5

Keywords

  • Antibiotics
  • Children
  • Chlamydia pneumoniae
  • Isolation

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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    Komoda, T., Bannai, H., Hagiwara, T., Iwata, S., Akita, H., Satou, Y., Yokota, T., & Sunakawa, K. (1998). Antimicrobial susceptibility of Chlamydia pneumoniae isolates from children and their families. Japanese Journal of Chemotherapy, 46(6), 205-209.